C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: serine (or cysteine) peptidase inhibitor, clade E, member 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000026249 Serpine2 10090 - 1:79794197-79861180 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000027467 Serpine2-001 79794197-79858696 protein_coding
  ENSMUST00000153862 Serpine2-002 79815108-79858696 retained_intron
  ENSMUST00000189793 Serpine2-004 79796845-79821322 protein_coding
  ENSMUST00000190724 Serpine2-005 79803035-79861180 protein_coding
  ENSMUST00000191026 Serpine2-006 79857507-79858635 retained_intron
  ENSMUST00000191529 Serpine2-003 79816912-79820304 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000027467ENSMUST00000189793ENSMUST00000190724ENSMUST00000191529
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000027467 14.142±10.03 3.001±1.59 5.813±0.11 21.205±5.97 3.126±1.38 4.774±2.96 5.453±0.54 3.845±2.14 2.165±1.06 27.873±8.04 21.888±6.53 87.005±44.09 40.119±11.13 2.095±1.53
ENSMUST00000189793 15.034±4.10 2.350±0.00 N/A 10.308±1.87 6.158±4.31 5.013±0.83 5.134±1.17 5.420±1.08 0.577±0.56 17.325±3.31 N/A 87.020±26.97 43.304±0.90 0.886±0.57
ENSMUST00000190724 5.234±0.00 3.109±0.00 N/A 18.150±0.00 N/A 5.946±0.79 N/A 4.484±0.81 0.304±0.00 N/A N/A 39.548±0.00 N/A 0.447±0.10
ENSMUST00000191529 N/A N/A N/A N/A N/A N/A N/A N/A 0.053±0.00 N/A N/A N/A N/A 0.085±0.02

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006XP CIL_0006XP_0002 CGP 1:79776018-79861180
CIL_0006XO CIL_0006XO_0002 CGP 1:79794197-80218473

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004867 IMP serine-type endopeptidase inhibitor activity
GO:0005102 IGI receptor binding
GO:0005515 IEA protein binding
GO:0005539 IEA glycosaminoglycan binding
GO:0005576 IDA extracellular region
GO:0005615 IBA extracellular space
GO:0005829 IEA cytosol
GO:0007596 IMP blood coagulation
GO:0008201 IEA heparin binding
GO:0008285 IGI negative regulation of cell proliferation
GO:0009611 IMP response to wounding
GO:0010466 IMP negative regulation of peptidase activity
GO:0010544 IMP negative regulation of platelet activation
GO:0010757 IMP negative regulation of plasminogen activation
GO:0010766 IGI negative regulation of sodium ion transport
GO:0010951 IEA negative regulation of endopeptidase activity
GO:0010955 IC negative regulation of protein processing
GO:0014067 IGI negative regulation of phosphatidylinositol 3-kinase signaling
GO:0021683 IMP cerebellar granular layer morphogenesis
GO:0030195 IEA negative regulation of blood coagulation
GO:0030308 IGI negative regulation of cell growth
GO:0031012 IEA extracellular matrix
GO:0031091 IEA platelet alpha granule
GO:0031232 IEA extrinsic component of external side of plasma membrane
GO:0031594 IDA neuromuscular junction
GO:0031982 IEA vesicle
GO:0032940 IMP secretion by cell
GO:0033363 IMP secretory granule organization
GO:0042177 IMP negative regulation of protein catabolic process
GO:0042628 IMP mating plug formation
GO:0045861 IEA negative regulation of proteolysis
GO:0045879 IGI negative regulation of smoothened signaling pathway
GO:0048505 IMP regulation of timing of cell differentiation
GO:0048711 IEA positive regulation of astrocyte differentiation
GO:0050974 IMP detection of mechanical stimulus involved in sensory perception
GO:0051966 IMP regulation of synaptic transmission, glutamatergic
GO:0060291 IMP long-term synaptic potentiation
GO:0060384 IMP innervation
GO:0061108 IMP seminal vesicle epithelium development
GO:0090331 IMP negative regulation of platelet aggregation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000029353 serpine2 serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 protein_coding Danio_rerio
ENSG00000135919 SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 protein_coding Homo_sapiens

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