C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000135919 SERPINE2 9606 - 2:223975112-224039319 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000258405 SERPINE2-001 223975112-224039319 protein_coding
  ENST00000409304 SERPINE2-002 223975112-224039288 protein_coding
  ENST00000409840 SERPINE2-003 223975153-224031478 protein_coding
  ENST00000423446 SERPINE2-009 224001774-224030801 protein_coding
  ENST00000432738 SERPINE2-008 223984809-224013949 protein_coding
  ENST00000447280 SERPINE2-005 223975682-224038804 protein_coding
  ENST00000454956 SERPINE2-007 224001641-224039318 protein_coding
  ENST00000473202 SERPINE2-004 223975153-223982780 retained_intron
  ENST00000478966 SERPINE2-010 223975814-223985068 retained_intron
  ENST00000489065 SERPINE2-006 224001552-224039290 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000258405ENST00000409304ENST00000432738ENST00000447280ENST00000454956ENST00000473202ENST00000478966
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000258405 4.198±0.00 N/A N/A 4.951±0.00 2.572±0.00 5.406±0.00 N/A 5.340±0.00 N/A N/A 0.035±0.00 21.644±3.35 232.002±90.28 8.167±0.00
ENST00000409304 15.272±0.00 16.709±0.00 N/A 37.839±22.31 2.191±1.14 10.319±9.49 3.282±2.51 15.510±0.00 1.691±0.79 3.525±3.39 0.081±0.03 58.799±55.67 910.882±480.95 34.618±9.19
ENST00000432738 N/A N/A 0.816±0.00 11.475±0.00 3.142±0.00 N/A N/A 2.098±0.00 N/A 1.399±0.00 0.341±0.00 6.449±1.69 297.488±0.00 17.250±0.00
ENST00000447280 N/A N/A 0.879±0.00 N/A N/A 0.730±0.00 N/A N/A 1.057±0.00 N/A N/A N/A N/A N/A
ENST00000454956 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.570±0.00 N/A N/A N/A
ENST00000473202 N/A N/A 0.251±0.00 N/A 0.317±0.00 0.163±0.00 N/A 0.078±0.00 0.266±0.00 0.077±0.00 N/A N/A N/A N/A
ENST00000478966 N/A N/A N/A N/A 3.055±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006XP CIL_0006XP_0001 CGP 2:223957404-224039319
CIL_0006XO CIL_0006XO_0001 CGP 2:223975112-224402085

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004867 IDA serine-type endopeptidase inhibitor activity
GO:0005102 IPI receptor binding
GO:0005515 IPI protein binding
GO:0005539 IDA glycosaminoglycan binding
GO:0005576 IDA extracellular region
GO:0005615 IEA:IBA extracellular space
GO:0005829 IDA cytosol
GO:0007596 IEA blood coagulation
GO:0008201 IDA heparin binding
GO:0008285 IEA negative regulation of cell proliferation
GO:0009611 IEA response to wounding
GO:0010466 IEA negative regulation of peptidase activity
GO:0010544 IEA negative regulation of platelet activation
GO:0010757 IMP negative regulation of plasminogen activation
GO:0010766 IEA negative regulation of sodium ion transport
GO:0010951 IBA negative regulation of endopeptidase activity
GO:0010955 IC negative regulation of protein processing
GO:0014067 IEA negative regulation of phosphatidylinositol 3-kinase signaling
GO:0021683 IEA cerebellar granular layer morphogenesis
GO:0030195 IDA negative regulation of blood coagulation
GO:0030308 IEA negative regulation of cell growth
GO:0030334 NAS regulation of cell migration
GO:0031012 IDA extracellular matrix
GO:0031091 IDA platelet alpha granule
GO:0031232 IDA extrinsic component of external side of plasma membrane
GO:0031594 ISS neuromuscular junction
GO:0031982 IDA vesicle
GO:0032940 IEA secretion by cell
GO:0033363 IEA secretory granule organization
GO:0042177 IEA negative regulation of protein catabolic process
GO:0042628 IEA mating plug formation
GO:0045861 IDA negative regulation of proteolysis
GO:0045879 IEA negative regulation of smoothened signaling pathway
GO:0048505 IEA regulation of timing of cell differentiation
GO:0048711 IDA positive regulation of astrocyte differentiation
GO:0050974 IEA detection of mechanical stimulus involved in sensory perception
GO:0051966 IEA regulation of synaptic transmission, glutamatergic
GO:0060291 IEA long-term synaptic potentiation
GO:0060384 IEA innervation
GO:0061108 IEA seminal vesicle epithelium development
GO:0090331 ISS negative regulation of platelet aggregation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000029353 serpine2 serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 protein_coding Danio_rerio
ENSMUSG00000026249 Serpine2 serine (or cysteine) peptidase inhibitor, clade E, member 2 protein_coding Mus_musculus

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