C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: serine (or cysteine) peptidase inhibitor, clade E, member 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000027467 Serpine2-001 ENSMUSG00000026249 10090 - 1:79794197-79858696 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000027467
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000027467 14.142±10.03 3.001±1.59 5.813±0.11 21.205±5.97 3.126±1.38 4.774±2.96 5.453±0.54 3.845±2.14 2.165±1.06 27.873±8.04 21.888±6.53 87.005±44.09 40.119±11.13 2.095±1.53

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006XP CIL_0006XP_0002 CGP 1:79776018-79861180
CIL_0006XO CIL_0006XO_0002 CGP 1:79794197-80218473

Gene Ontology

GO IDEvidence TypeGO Description
GO:0004867 IMP serine-type endopeptidase inhibitor activity
GO:0005102 IGI receptor binding
GO:0005515 IEA protein binding
GO:0005539 IEA glycosaminoglycan binding
GO:0005576 IDA extracellular region
GO:0005615 IBA extracellular space
GO:0005829 IEA cytosol
GO:0007596 IMP blood coagulation
GO:0008201 IEA heparin binding
GO:0008285 IGI negative regulation of cell proliferation
GO:0009611 IMP response to wounding
GO:0010466 IMP negative regulation of peptidase activity
GO:0010544 IMP negative regulation of platelet activation
GO:0010757 IMP negative regulation of plasminogen activation
GO:0010766 IGI negative regulation of sodium ion transport
GO:0010951 IEA negative regulation of endopeptidase activity
GO:0010955 IC negative regulation of protein processing
GO:0014067 IGI negative regulation of phosphatidylinositol 3-kinase signaling
GO:0021683 IMP cerebellar granular layer morphogenesis
GO:0030195 IEA negative regulation of blood coagulation
GO:0030308 IGI negative regulation of cell growth
GO:0031012 IEA extracellular matrix
GO:0031091 IEA platelet alpha granule
GO:0031232 IEA extrinsic component of external side of plasma membrane
GO:0031594 IDA neuromuscular junction
GO:0031982 IEA vesicle
GO:0032940 IMP secretion by cell
GO:0033363 IMP secretory granule organization
GO:0042177 IMP negative regulation of protein catabolic process
GO:0042628 IMP mating plug formation
GO:0045861 IEA negative regulation of proteolysis
GO:0045879 IGI negative regulation of smoothened signaling pathway
GO:0048505 IMP regulation of timing of cell differentiation
GO:0048711 IEA positive regulation of astrocyte differentiation
GO:0050974 IMP detection of mechanical stimulus involved in sensory perception
GO:0051966 IMP regulation of synaptic transmission, glutamatergic
GO:0060291 IMP long-term synaptic potentiation
GO:0060384 IMP innervation
GO:0061108 IMP seminal vesicle epithelium development
GO:0090331 IMP negative regulation of platelet aggregation

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000258405 SERPINE2-001 protein_coding Homo_sapiens 0 1303
ENST00000409304 SERPINE2-002 protein_coding Homo_sapiens 0 1317
ENST00000409840 SERPINE2-003 protein_coding Homo_sapiens 0 1288
ENST00000447280 SERPINE2-005 protein_coding Homo_sapiens 0 1288
ENST00000473202 SERPINE2-004 retained_intron Homo_sapiens 0 220
ENST00000478966 SERPINE2-010 retained_intron Homo_sapiens 0 621

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