C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: histone deacetylase 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000026313 Hdac4 10090 - 1:91928779-92180341 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000008995 Hdac4-201 91932757-92148393 protein_coding
  ENSMUST00000097644 Hdac4-001 91928779-92180341 protein_coding
  ENSMUST00000185267 Hdac4-008 92003670-92006860 retained_intron
  ENSMUST00000185341 Hdac4-007 92029966-92113331 processed_transcript
  ENSMUST00000186002 Hdac4-003 92029955-92180297 protein_coding
  ENSMUST00000187308 Hdac4-004 91955374-91975501 protein_coding
  ENSMUST00000187622 Hdac4-006 92030050-92113331 processed_transcript
  ENSMUST00000189303 Hdac4-002 91932958-92006855 processed_transcript
  ENSMUST00000189730 Hdac4-009 91989051-91992626 retained_intron
  ENSMUST00000191327 Hdac4-005 91933203-91934864 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000008995ENSMUST00000097644ENSMUST00000189303
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000008995 N/A 7.685±1.68 N/A N/A 2.546±0.36 3.062±1.04 0.977±0.00 1.223±0.00 N/A 1.967±0.68 N/A 8.412±1.42 4.024±0.28 2.401±0.32
ENSMUST00000097644 3.182±1.20 12.353±4.37 1.890±0.19 4.446±2.56 2.813±1.48 4.525±1.37 1.302±0.34 1.470±0.12 0.634±0.36 4.081±1.70 1.220±0.33 5.850±2.66 2.642±1.27 0.464±0.17
ENSMUST00000189303 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.943±0.00 2.840±0.36

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007UT CIL_0007UT_0002 VISTA 1:91662928-92265960
CIL_0003NG CIL_0003NG_0002 CGP 1:91801461-92180341

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000118 IEA histone deacetylase complex
GO:0000122 IGI negative regulation of transcription from RNA polymerase II promoter
GO:0001047 IEA core promoter binding
GO:0001501 IMP skeletal system development
GO:0002076 IMP osteoblast development
GO:0003677 IDA DNA binding
GO:0003714 IGI transcription corepressor activity
GO:0005515 IPI protein binding
GO:0005634 IMP nucleus
GO:0005737 IMP cytoplasm
GO:0005829 IDA cytosol
GO:0006338 IEA chromatin remodeling
GO:0006351 IEA transcription, DNA-templated
GO:0006476 IDA protein deacetylation
GO:0008134 IPI transcription factor binding
GO:0008270 IEA zinc ion binding
GO:0008284 IEA positive regulation of cell proliferation
GO:0008285 IDA negative regulation of cell proliferation
GO:0010832 IEA negative regulation of myotube differentiation
GO:0010882 IMP regulation of cardiac muscle contraction by calcium ion signaling
GO:0014894 IMP response to denervation involved in regulation of muscle adaptation
GO:0016575 IEA histone deacetylation
GO:0017053 IEA transcriptional repressor complex
GO:0019901 IPI protein kinase binding
GO:0030017 IEA sarcomere
GO:0030018 IEA Z disc
GO:0030955 IEA potassium ion binding
GO:0031594 IDA neuromuscular junction
GO:0031672 IEA A band
GO:0032041 IEA NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0033235 ISS positive regulation of protein sumoylation
GO:0033558 IDA protein deacetylase activity
GO:0033613 IEA activating transcription factor binding
GO:0034983 IEA peptidyl-lysine deacetylation
GO:0040029 IEA regulation of gene expression, epigenetic
GO:0042493 IEA response to drug
GO:0042641 IDA actomyosin
GO:0042826 IEA histone deacetylase binding
GO:0043234 IEA protein complex
GO:0043393 IEA regulation of protein binding
GO:0043433 IEA negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043565 IEA sequence-specific DNA binding
GO:0044212 IEA transcription regulatory region DNA binding
GO:0045668 IMP negative regulation of osteoblast differentiation
GO:0045820 IMP negative regulation of glycolytic process
GO:0045892 IMP negative regulation of transcription, DNA-templated
GO:0045893 IMP positive regulation of transcription, DNA-templated
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0046872 IEA metal ion binding
GO:0046969 IEA NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970 IEA NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0048742 IGI regulation of skeletal muscle fiber development
GO:0051091 IEA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051153 IGI regulation of striated muscle cell differentiation
GO:0070491 IEA repressing transcription factor binding
GO:0070555 IEA response to interleukin-1
GO:0070932 IEA histone H3 deacetylation
GO:0070933 IEA histone H4 deacetylation
GO:0097372 IEA NAD-dependent histone deacetylase activity (H3-K18 specific)

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000041204 hdac4 histone deacetylase 4 protein_coding Danio_rerio
ENSG00000068024 HDAC4 histone deacetylase 4 protein_coding Homo_sapiens

Loading