C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: histone deacetylase 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000068024 HDAC4 9606 - 2:239048168-239401654 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000345617 HDAC4-001 239048168-239400949 protein_coding
  ENST00000430200 HDAC4-013 239053046-239066981 protein_coding
  ENST00000445704 HDAC4-009 239134325-239140973 protein_coding
  ENST00000446876 HDAC4-007 239176453-239309212 protein_coding
  ENST00000454542 HDAC4-008 239163833-239191056 protein_coding
  ENST00000460235 HDAC4-011 239102609-239108104 retained_intron
  ENST00000461113 HDAC4-006 239126633-239155013 retained_intron
  ENST00000463007 HDAC4-004 239089676-239298639 retained_intron
  ENST00000487617 HDAC4-014 239080918-239108053 retained_intron
  ENST00000493582 HDAC4-002 239094574-239401654 retained_intron
  ENST00000494800 HDAC4-012 239055184-239081135 processed_transcript
  ENST00000495497 HDAC4-010 239091144-239102841 retained_intron
  ENST00000496347 HDAC4-005 239186488-239236669 retained_intron
  ENST00000535493 HDAC4-016 239094890-239298530 retained_intron
  ENST00000543185 HDAC4-201 239048169-239400949 protein_coding
  ENST00000544989 HDAC4-015 239236598-239401011 protein_coding
  ENST00000553145 HDAC4-018 239134349-239155575 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBrainBreastHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000345617ENST00000463007ENST00000493582ENST00000543185ENST00000544989
Transcript ID Adipose Brain Breast Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000345617 0.737±0.00 0.708±0.00 N/A 0.562±0.00 N/A N/A 0.784±0.00 3.481±0.00 2.007±0.40 0.225±0.00 1.184±0.00
ENST00000463007 N/A N/A N/A N/A N/A N/A N/A 2.980±0.00 N/A N/A N/A
ENST00000493582 N/A N/A 0.765±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000543185 0.919±0.00 0.589±0.00 N/A 0.578±0.00 N/A 0.579±0.00 N/A N/A 1.356±0.33 N/A N/A
ENST00000544989 N/A N/A N/A N/A 4.957±0.00 N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007UT CIL_0007UT_0001 VISTA 2:238792799-239398211
CIL_0003NG CIL_0003NG_0001 CGP 2:238848032-239401654

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000118 IDA:IEA histone deacetylase complex
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0001047 IDA core promoter binding
GO:0001501 IEA skeletal system development
GO:0002076 IEA osteoblast development
GO:0003677 IEA DNA binding
GO:0003714 IEA transcription corepressor activity
GO:0004407 IDA:IEA histone deacetylase activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 IEA cytosol
GO:0006338 IDA chromatin remodeling
GO:0006351 IEA transcription, DNA-templated
GO:0006476 IEA protein deacetylation
GO:0006954 TAS inflammatory response
GO:0007399 TAS nervous system development
GO:0008134 IPI transcription factor binding
GO:0008270 IDA zinc ion binding
GO:0008284 IMP positive regulation of cell proliferation
GO:0008285 IEA negative regulation of cell proliferation
GO:0010832 IMP negative regulation of myotube differentiation
GO:0010882 IEA regulation of cardiac muscle contraction by calcium ion signaling
GO:0014894 ISS response to denervation involved in regulation of muscle adaptation
GO:0014898 TAS cardiac muscle hypertrophy in response to stress
GO:0016568 IEA chromatin modification
GO:0016575 IDA histone deacetylation
GO:0017053 IDA transcriptional repressor complex
GO:0019901 IEA protein kinase binding
GO:0030017 IEA sarcomere
GO:0030018 IEA Z disc
GO:0030183 TAS B cell differentiation
GO:0030955 IDA potassium ion binding
GO:0031594 IEA neuromuscular junction
GO:0031672 IEA A band
GO:0032041 IEA NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0033235 IDA positive regulation of protein sumoylation
GO:0033558 IDA protein deacetylase activity
GO:0033613 IPI activating transcription factor binding
GO:0034983 IDA peptidyl-lysine deacetylation
GO:0040029 IMP regulation of gene expression, epigenetic
GO:0042113 TAS B cell activation
GO:0042493 IEA response to drug
GO:0042641 IEA actomyosin
GO:0042826 IPI histone deacetylase binding
GO:0043234 IEA protein complex
GO:0043393 IMP regulation of protein binding
GO:0043433 IMP negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043565 IDA sequence-specific DNA binding
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045668 IEA negative regulation of osteoblast differentiation
GO:0045820 ISS negative regulation of glycolytic process
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0046969 IEA NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970 IEA NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0048742 IEA regulation of skeletal muscle fiber development
GO:0051091 IMP positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051153 IEA regulation of striated muscle cell differentiation
GO:0070491 IPI repressing transcription factor binding
GO:0070555 IMP response to interleukin-1
GO:0070932 IDA histone H3 deacetylation
GO:0070933 IDA histone H4 deacetylation
GO:0097372 IEA NAD-dependent histone deacetylase activity (H3-K18 specific)

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000041204 hdac4 histone deacetylase 4 protein_coding Danio_rerio
ENSMUSG00000026313 Hdac4 histone deacetylase 4 protein_coding Mus_musculus

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