C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: ceroid-lipofuscinosis, neuronal 8
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000026317 Cln8 10090 + 8:14881335-14901720 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000027554 Cln8-001 14888111-14901720 protein_coding
  ENSMUST00000123990 Cln8-002 14888045-14895059 protein_coding
  ENSMUST00000128839 Cln8-004 14889359-14894919 protein_coding
  ENSMUST00000132001 Cln8-005 14881335-14894716 protein_coding
  ENSMUST00000133578 Cln8-003 14889004-14894786 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000027554ENSMUST00000123990
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000027554 2.544±0.59 2.606±0.18 2.331±0.59 1.288±0.57 2.501±0.46 2.361±0.45 1.478±0.09 1.970±0.50 2.876±1.31 2.822±0.40 1.001±0.29 4.398±2.20 2.271±0.61 0.205±0.11
ENSMUST00000123990 N/A N/A N/A N/A 13.883±0.00 5.174±1.11 N/A N/A 5.494±0.00 N/A N/A 11.212±1.69 N/A 1.074±0.12

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007GL CIL_0007GL_0003 CGP 8:14881335-15001085

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001306 IMP age-dependent response to oxidative stress
GO:0005739 IMP mitochondrion
GO:0005783 ISS endoplasmic reticulum
GO:0005793 ISS endoplasmic reticulum-Golgi intermediate compartment
GO:0006644 IMP:ISS phospholipid metabolic process
GO:0006672 ISS ceramide metabolic process
GO:0007006 IMP mitochondrial membrane organization
GO:0007040 IMP lysosome organization
GO:0007399 ISS nervous system development
GO:0007601 IMP visual perception
GO:0007628 IMP adult walking behavior
GO:0008203 ISS cholesterol metabolic process
GO:0008219 IEA cell death
GO:0008306 IMP associative learning
GO:0008344 IMP adult locomotory behavior
GO:0008361 IMP regulation of cell size
GO:0016021 IEA integral component of membrane
GO:0021522 IMP spinal cord motor neuron differentiation
GO:0021523 IMP somatic motor neuron differentiation
GO:0035176 IMP social behavior
GO:0043066 IMP negative regulation of apoptotic process
GO:0044257 IMP cellular protein catabolic process
GO:0044265 IMP cellular macromolecule catabolic process
GO:0044267 IMP cellular protein metabolic process
GO:0045494 IMP photoreceptor cell maintenance
GO:0050881 IMP musculoskeletal movement
GO:0050884 IMP neuromuscular process controlling posture
GO:0050885 IMP neuromuscular process controlling balance
GO:0051348 IMP negative regulation of transferase activity
GO:0051935 IMP L-glutamate uptake involved in synaptic transmission
GO:0060041 IMP retina development in camera-type eye
GO:0060052 IMP neurofilament cytoskeleton organization

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000075525 cln8 ceroid-lipofuscinosis, neuronal 8 protein_coding Danio_rerio
ENSG00000182372 CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) protein_coding Homo_sapiens

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