C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: protein tyrosine phosphatase, receptor type, C
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000026395 Ptprc 10090 - 1:138063407-138175706 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000112036 Ptprc-009 138063415-138116441 retained_intron
  ENSMUST00000182138 Ptprc-007 138123873-138175245 retained_intron
  ENSMUST00000182283 Ptprc-002 138063407-138175305 protein_coding
  ENSMUST00000182755 Ptprc-003 138063407-138175299 protein_coding
  ENSMUST00000183229 Ptprc-006 138126209-138175706 retained_intron
  ENSMUST00000183262 Ptprc-004 138119473-138175299 retained_intron
  ENSMUST00000183301 Ptprc-001 138063413-138175267 protein_coding
  ENSMUST00000185570 Ptprc-011 138171977-138175189 retained_intron
  ENSMUST00000186628 Ptprc-010 138172744-138175249 retained_intron
  ENSMUST00000187586 Ptprc-008 138117337-138120720 retained_intron
  ENSMUST00000188596 Ptprc-012 138112030-138115473 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000112036ENSMUST00000182283ENSMUST00000182755ENSMUST00000183262ENSMUST00000183301ENSMUST00000187586
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000112036 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.039±0.01 0.634±0.23 0.076±0.02 N/A
ENSMUST00000182283 4.425±1.14 1.324±0.69 4.265±0.31 0.194±0.01 21.041±2.39 1.128±0.28 0.869±0.30 1.347±0.65 2.551±2.61 9.377±1.29 1.221±1.09 1.711±0.71 0.659±0.44 0.163±0.03
ENSMUST00000182755 N/A N/A 1.245±0.17 0.376±0.00 N/A N/A 0.332±0.00 0.312±0.00 1.269±0.79 N/A 0.202±0.06 0.808±0.43 0.602±0.22 0.108±0.00
ENSMUST00000183262 N/A N/A N/A N/A N/A 2.611±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000183301 0.672±0.00 0.333±0.00 N/A 0.035±0.00 31.509±17.69 3.172±0.51 0.775±0.38 1.214±1.02 0.708±0.19 7.003±3.06 3.046±0.00 0.730±0.26 0.174±0.04 0.027±0.00
ENSMUST00000187586 2.360±0.53 1.438±0.32 N/A N/A 17.490±6.44 1.653±0.18 0.864±0.01 0.873±0.37 0.306±0.19 6.860±0.72 N/A 1.836±0.51 N/A 0.086±0.05

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000187 IMP activation of MAPK activity
GO:0001915 IMP negative regulation of T cell mediated cytotoxicity
GO:0001916 IMP positive regulation of T cell mediated cytotoxicity
GO:0001960 IDA negative regulation of cytokine-mediated signaling pathway
GO:0002244 IEA hematopoietic progenitor cell differentiation
GO:0002378 IEA immunoglobulin biosynthetic process
GO:0002711 IMP positive regulation of T cell mediated immunity
GO:0002923 IMP regulation of humoral immune response mediated by circulating immunoglobulin
GO:0002925 IMP positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0004725 IDA protein tyrosine phosphatase activity
GO:0005515 IPI protein binding
GO:0005886 IDA plasma membrane
GO:0005887 ISS integral component of plasma membrane
GO:0005925 IDA focal adhesion
GO:0006469 ISS negative regulation of protein kinase activity
GO:0006470 IDA protein dephosphorylation
GO:0006933 IEA negative regulation of cell adhesion involved in substrate-bound cell migration
GO:0007159 IMP leukocyte cell-cell adhesion
GO:0008201 IDA heparin binding
GO:0009897 IDA external side of plasma membrane
GO:0009986 IEA cell surface
GO:0010332 IEA response to gamma radiation
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0016311 IDA dephosphorylation
GO:0019901 ISS protein kinase binding
GO:0030183 IMP B cell differentiation
GO:0030217 IMP T cell differentiation
GO:0030890 IMP positive regulation of B cell proliferation
GO:0031953 IMP negative regulation of protein autophosphorylation
GO:0034113 IMP heterotypic cell-cell adhesion
GO:0035335 IEA peptidyl-tyrosine dephosphorylation
GO:0042098 IMP T cell proliferation
GO:0042100 IMP B cell proliferation
GO:0042102 IMP positive regulation of T cell proliferation
GO:0043395 IDA heparan sulfate proteoglycan binding
GO:0043410 IMP positive regulation of MAPK cascade
GO:0044770 IEA cell cycle phase transition
GO:0045059 IMP positive thymic T cell selection
GO:0045060 IMP negative thymic T cell selection
GO:0045577 IMP regulation of B cell differentiation
GO:0045582 IMP positive regulation of T cell differentiation
GO:0045588 IMP positive regulation of gamma-delta T cell differentiation
GO:0046641 IMP positive regulation of alpha-beta T cell proliferation
GO:0048304 IMP positive regulation of isotype switching to IgG isotypes
GO:0048539 IEA bone marrow development
GO:0048864 IEA stem cell development
GO:0050732 IMP negative regulation of peptidyl-tyrosine phosphorylation
GO:0050852 IEA T cell receptor signaling pathway
GO:0050853 IMP B cell receptor signaling pathway
GO:0050855 IMP regulation of B cell receptor signaling pathway
GO:0050857 IMP positive regulation of antigen receptor-mediated signaling pathway
GO:0051209 IDA release of sequestered calcium ion into cytosol
GO:0051607 IDA defense response to virus
GO:0051726 IDA regulation of cell cycle
GO:0070062 IEA extracellular vesicular exosome
GO:0071944 IDA cell periphery
GO:2000473 IEA positive regulation of hematopoietic stem cell migration
GO:2000648 IEA positive regulation of stem cell proliferation
GO:2001236 IMP regulation of extrinsic apoptotic signaling pathway
GO:2001238 IMP positive regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000071437 ptprc protein tyrosine phosphatase, receptor type, C protein_coding Danio_rerio
ENSG00000081237 PTPRC protein tyrosine phosphatase, receptor type, C protein_coding Homo_sapiens

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