C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: protein tyrosine phosphatase, receptor type, C
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000183301 Ptprc-001 ENSMUSG00000026395 10090 - 1:138063413-138175267 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000183301
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000183301 0.672±0.00 0.333±0.00 0.035±0.00 31.509±17.69 3.172±0.51 0.775±0.38 1.214±1.02 0.708±0.19 7.003±3.06 3.046±0.00 0.730±0.26 0.174±0.04 0.027±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000187 IMP activation of MAPK activity
GO:0001915 IMP negative regulation of T cell mediated cytotoxicity
GO:0001916 IMP positive regulation of T cell mediated cytotoxicity
GO:0001960 IDA negative regulation of cytokine-mediated signaling pathway
GO:0002244 IEA hematopoietic progenitor cell differentiation
GO:0002378 IEA immunoglobulin biosynthetic process
GO:0002711 IMP positive regulation of T cell mediated immunity
GO:0002923 IMP regulation of humoral immune response mediated by circulating immunoglobulin
GO:0002925 IMP positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0004725 IDA:ISS protein tyrosine phosphatase activity
GO:0005515 IPI protein binding
GO:0005886 IDA plasma membrane
GO:0005887 ISS integral component of plasma membrane
GO:0005925 IDA focal adhesion
GO:0006469 ISS negative regulation of protein kinase activity
GO:0006470 IDA protein dephosphorylation
GO:0006933 IEA negative regulation of cell adhesion involved in substrate-bound cell migration
GO:0007159 IMP leukocyte cell-cell adhesion
GO:0008201 IDA heparin binding
GO:0009897 IDA external side of plasma membrane
GO:0009986 IEA cell surface
GO:0010332 IEA response to gamma radiation
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0016311 IDA dephosphorylation
GO:0019901 ISS protein kinase binding
GO:0030183 IMP B cell differentiation
GO:0030217 IMP T cell differentiation
GO:0030890 IMP positive regulation of B cell proliferation
GO:0031953 IMP negative regulation of protein autophosphorylation
GO:0034113 IMP heterotypic cell-cell adhesion
GO:0035335 IEA peptidyl-tyrosine dephosphorylation
GO:0042098 IMP T cell proliferation
GO:0042100 IMP B cell proliferation
GO:0042102 IMP positive regulation of T cell proliferation
GO:0043395 IDA heparan sulfate proteoglycan binding
GO:0043410 IMP positive regulation of MAPK cascade
GO:0044770 IEA cell cycle phase transition
GO:0045059 IMP positive thymic T cell selection
GO:0045060 IMP negative thymic T cell selection
GO:0045577 IMP regulation of B cell differentiation
GO:0045582 IMP positive regulation of T cell differentiation
GO:0045588 IMP positive regulation of gamma-delta T cell differentiation
GO:0046641 IMP positive regulation of alpha-beta T cell proliferation
GO:0048304 IMP positive regulation of isotype switching to IgG isotypes
GO:0048539 IEA bone marrow development
GO:0048864 IEA stem cell development
GO:0050732 IMP negative regulation of peptidyl-tyrosine phosphorylation
GO:0050852 ISS T cell receptor signaling pathway
GO:0050853 IMP B cell receptor signaling pathway
GO:0050855 IMP regulation of B cell receptor signaling pathway
GO:0050857 IMP positive regulation of antigen receptor-mediated signaling pathway
GO:0051209 IDA release of sequestered calcium ion into cytosol
GO:0051607 IDA defense response to virus
GO:0051726 IDA regulation of cell cycle
GO:0070062 IEA extracellular vesicular exosome
GO:0071944 IDA cell periphery
GO:2000473 IEA positive regulation of hematopoietic stem cell migration
GO:2000648 IEA positive regulation of stem cell proliferation
GO:2001236 IMP regulation of extrinsic apoptotic signaling pathway
GO:2001238 IMP positive regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000105607 ptprc-201 protein_coding Danio_rerio 0 326
ENSDART00000137111 ptprc-001 protein_coding Danio_rerio 0 326
ENST00000348564 PTPRC-002 protein_coding Homo_sapiens 0 2143
ENST00000367367 PTPRC-005 protein_coding Homo_sapiens 0 784
ENST00000442510 PTPRC-001 protein_coding Homo_sapiens 0 2143
ENST00000529828 PTPRC-010 non_stop_decay Homo_sapiens 0 784
ENST00000530727 PTPRC-006 protein_coding Homo_sapiens 0 499

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