C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Fc receptor, IgG, low affinity IIb
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000026656 Fcgr2b 10090 - 1:170960558-170976547 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000027966 Fcgr2b-001 170960558-170976127 protein_coding
  ENSMUST00000081103 Fcgr2b-003 170960558-170976127 protein_coding
  ENSMUST00000159688 Fcgr2b-005 170960993-170976127 protein_coding
  ENSMUST00000159969 Fcgr2b-002 170960769-170976547 protein_coding
  ENSMUST00000160106 Fcgr2b-004 170964333-170976127 retained_intron
  ENSMUST00000161503 Fcgr2b-007 170960734-170961630 processed_transcript
  ENSMUST00000161730 Fcgr2b-006 170969260-170976127 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000027966ENSMUST00000081103ENSMUST00000159688ENSMUST00000159969ENSMUST00000160106ENSMUST00000161503ENSMUST00000161730
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000027966 N/A 0.885±0.01 N/A N/A 2.799±0.32 N/A N/A N/A 0.924±0.13 1.246±0.13 0.235±0.02 1.840±0.17 0.054±0.02 N/A
ENSMUST00000081103 9.410±0.94 1.500±0.69 10.718±1.11 0.285±0.06 8.040±2.59 3.628±1.60 2.921±0.65 15.333±5.11 8.507±6.73 5.049±0.47 0.874±0.56 5.634±3.23 1.894±2.13 0.722±0.42
ENSMUST00000159688 3.912±0.00 2.883±0.65 N/A N/A 5.406±0.89 3.540±1.51 N/A 10.805±1.37 N/A N/A N/A 5.006±1.54 N/A 2.331±0.82
ENSMUST00000159969 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.531±0.00 0.196±0.00 N/A
ENSMUST00000160106 2.452±0.42 0.852±0.07 2.054±0.00 0.026±0.00 3.241±0.50 0.717±0.05 0.546±0.21 N/A 0.945±0.67 1.995±0.68 0.103±0.01 1.467±0.00 0.017±0.01 0.382±0.22
ENSMUST00000161503 N/A 1.507±0.29 N/A 0.341±0.28 7.147±0.70 N/A 1.301±0.00 N/A 1.108±0.16 2.568±0.53 N/A 7.398±0.00 0.735±0.62 0.038±0.00
ENSMUST00000161730 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.183±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005I8 CIL_0005I8_0002 CGP 1:170960558-171029761

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001811 IMP negative regulation of type I hypersensitivity
GO:0002638 IMP negative regulation of immunoglobulin production
GO:0002862 IMP negative regulation of inflammatory response to antigenic stimulus
GO:0002865 IMP negative regulation of acute inflammatory response to antigenic stimulus
GO:0002924 IMP negative regulation of humoral immune response mediated by circulating immunoglobulin
GO:0005057 TAS receptor signaling protein activity
GO:0005576 IEA extracellular region
GO:0005737 IEA cytoplasm
GO:0005856 IEA cytoskeleton
GO:0005887 IC integral component of plasma membrane
GO:0006911 IDA phagocytosis, engulfment
GO:0006952 IMP defense response
GO:0006955 IMP immune response
GO:0007166 IMP cell surface receptor signaling pathway
GO:0009617 IMP response to bacterium
GO:0009897 IDA external side of plasma membrane
GO:0016021 IDA integral component of membrane
GO:0016064 IMP immunoglobulin mediated immune response
GO:0019864 IDA IgG binding
GO:0019886 IMP antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0030889 IMP negative regulation of B cell proliferation
GO:0032693 IMP negative regulation of interleukin-10 production
GO:0035556 TAS intracellular signal transduction
GO:0050765 IMP negative regulation of phagocytosis
GO:0050766 IDA positive regulation of phagocytosis
GO:0050777 IMP negative regulation of immune response
GO:0071219 IMP cellular response to molecule of bacterial origin

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000072694 FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) protein_coding Homo_sapiens
ENSG00000143226 FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) protein_coding Homo_sapiens
ENSG00000244682 FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene) polymorphic_pseudogene Homo_sapiens

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