C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: proprotein convertase subtilisin/kexin type 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000027419 Pcsk2 10090 + 2:143546156-143816285 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000028905 Pcsk2-002 143546156-143816285 protein_coding
  ENSMUST00000124751 Pcsk2-001 143546271-143576734 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000028905ENSMUST00000124751
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000028905 0.026±0.01 0.703±0.27 0.069±0.02 22.222±23.54 0.046±0.02 0.807±0.15 0.016±0.01 0.053±0.01 0.013±0.01 0.113±0.09 0.008±0.00 0.064±0.05 0.007±0.00 0.123±0.00
ENSMUST00000124751 0.026±0.01 N/A N/A N/A 0.018±0.00 N/A 0.011±0.00 0.025±0.00 0.017±0.00 0.040±0.00 N/A 0.048±0.00 0.007±0.00 0.024±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002DI CIL_0002DI_0002 CGP 2:143078473-143816285
CIL_0007A3 CIL_0007A3_0003 CGP 2:143546156-143863173

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004175 IDA endopeptidase activity
GO:0004252 IDA serine-type endopeptidase activity
GO:0005515 IEA protein binding
GO:0005615 IDA extracellular space
GO:0005788 TAS endoplasmic reticulum lumen
GO:0006508 IMP proteolysis
GO:0007399 IEP nervous system development
GO:0016020 IEA membrane
GO:0016485 IDA protein processing
GO:0016486 IMP peptide hormone processing
GO:0016540 IDA protein autoprocessing
GO:0030070 IEA insulin processing
GO:0030141 IEA secretory granule
GO:0030425 IEA dendrite
GO:0031410 IEA cytoplasmic vesicle
GO:0032403 IEA protein complex binding
GO:0034230 IDA enkephalin processing
GO:0034231 IEA islet amyloid polypeptide processing
GO:0043025 IEA neuronal cell body
GO:0043204 IEA perikaryon

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000019451 pcsk2 proprotein convertase subtilisin/kexin type 2 protein_coding Danio_rerio
ENSG00000125851 PCSK2 proprotein convertase subtilisin/kexin type 2 protein_coding Homo_sapiens

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