C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: proprotein convertase subtilisin/kexin type 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000125851 PCSK2 9606 + 20:17226107-17484578 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000262545 PCSK2-001 17226991-17484578 protein_coding
  ENST00000377899 PCSK2-002 17226107-17484578 protein_coding
  ENST00000459871 PCSK2-004 17463433-17482287 processed_transcript
  ENST00000470007 PCSK2-003 17228131-17409310 processed_transcript
  ENST00000536609 PCSK2-005 17227056-17482283 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000262545ENST00000377899ENST00000459871ENST00000470007ENST00000536609
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000262545 N/A N/A 0.021±0.00 5.512±4.06 0.018±0.00 N/A N/A N/A N/A N/A N/A 0.552±0.02 0.116±0.00 0.679±0.00
ENST00000377899 0.020±0.00 0.045±0.00 N/A 10.851±0.00 N/A 0.578±0.50 0.371±0.00 N/A N/A 0.092±0.00 N/A N/A N/A 0.233±0.00
ENST00000459871 0.017±0.00 0.088±0.00 N/A N/A 0.022±0.00 N/A N/A N/A N/A 0.149±0.00 N/A N/A N/A N/A
ENST00000470007 N/A N/A N/A N/A N/A 0.754±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000536609 N/A N/A N/A 6.846±0.00 0.071±0.00 1.717±1.40 0.431±0.00 0.122±0.05 0.188±0.18 1.058±0.00 0.054±0.03 1.737±1.58 0.527±0.25 2.540±1.24

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002DI CIL_0002DI_0001 CGP 20:16748358-17484578
CIL_0007A3 CIL_0007A3_0002 CGP 20:17226107-17569220

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004175 IEA endopeptidase activity
GO:0004252 IDA:IEA serine-type endopeptidase activity
GO:0005515 IPI protein binding
GO:0005615 IDA extracellular space
GO:0006508 IDA:IEA proteolysis
GO:0007399 IEA nervous system development
GO:0016020 IDA membrane
GO:0016485 IEA protein processing
GO:0016486 IEA peptide hormone processing
GO:0016540 IEA protein autoprocessing
GO:0030070 IDA insulin processing
GO:0030141 IEA secretory granule
GO:0030425 IEA dendrite
GO:0032403 IEA protein complex binding
GO:0034230 ISS enkephalin processing
GO:0034231 ISS islet amyloid polypeptide processing
GO:0034774 TAS secretory granule lumen
GO:0043025 IEA neuronal cell body
GO:0043204 IEA perikaryon
GO:0044267 TAS cellular protein metabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000019451 pcsk2 proprotein convertase subtilisin/kexin type 2 protein_coding Danio_rerio
ENSMUSG00000027419 Pcsk2 proprotein convertase subtilisin/kexin type 2 protein_coding Mus_musculus

Loading