C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: aurora kinase A
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000027496 Aurka 10090 - 2:172356190-172370535 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000028997 Aurka-201 172356196-172370506 protein_coding
  ENSMUST00000109139 Aurka-002 172356196-172370506 protein_coding
  ENSMUST00000109140 Aurka-001 172356190-172370535 protein_coding
  ENSMUST00000126107 Aurka-003 172366549-172370521 retained_intron
  ENSMUST00000128004 Aurka-004 172357166-172363131 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000028997ENSMUST00000109140ENSMUST00000126107ENSMUST00000128004
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000028997 N/A N/A 0.209±0.00 1.098±0.44 0.264±0.00 N/A N/A N/A 6.956±2.88 N/A N/A N/A 1.268±0.00 5.291±0.00
ENSMUST00000109140 2.950±1.77 1.277±0.05 1.409±0.08 6.021±4.32 1.713±0.48 5.252±0.58 0.321±0.07 0.502±0.18 35.218±26.20 0.953±0.25 0.715±0.43 7.826±1.62 22.064±11.47 39.537±15.14
ENSMUST00000126107 N/A 0.808±0.00 N/A N/A N/A N/A 0.145±0.00 N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000128004 N/A N/A N/A N/A N/A N/A 0.223±0.00 N/A N/A N/A 2.121±0.08 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00099D CIL_00099D_0002 VISTA 2:172130534-172731364
CIL_0001I0 CIL_0001I0_0002 CGP 2:172345565-172370535
CIL_0002PV CIL_0002PV_0002 CGP 2:172356190-172382448

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000212 IMP meiotic spindle organization
GO:0000226 IGI microtubule cytoskeleton organization
GO:0000278 IMP mitotic cell cycle
GO:0004672 ISS protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005813 IDA centrosome
GO:0005815 IGI microtubule organizing center
GO:0005876 IEA spindle microtubule
GO:0006468 IGI protein phosphorylation
GO:0007052 IMP mitotic spindle organization
GO:0007057 IMP spindle assembly involved in female meiosis I
GO:0007067 IMP mitotic nuclear division
GO:0007100 IGI mitotic centrosome separation
GO:0007126 IMP meiotic nuclear division
GO:0009948 IMP anterior/posterior axis specification
GO:0015630 IEA microtubule cytoskeleton
GO:0019901 IEA protein kinase binding
GO:0031616 IEA spindle pole centrosome
GO:0031625 IPI ubiquitin protein ligase binding
GO:0031647 IEA regulation of protein stability
GO:0032091 IEA negative regulation of protein binding
GO:0032436 IMP positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0035174 IMP histone serine kinase activity
GO:0035404 IMP histone-serine phosphorylation
GO:0042585 IDA germinal vesicle
GO:0043066 IMP negative regulation of apoptotic process
GO:0043146 IEA spindle stabilization
GO:0043203 IDA axon hillock
GO:0045120 IDA pronucleus
GO:0048471 IEA perinuclear region of cytoplasm
GO:0051297 IGI centrosome organization
GO:0051642 IMP centrosome localization
GO:0071539 IMP protein localization to centrosome
GO:0072686 IDA mitotic spindle
GO:0072687 IDA meiotic spindle
GO:0090233 IMP negative regulation of spindle checkpoint
GO:1900195 IMP positive regulation of oocyte maturation
GO:1990138 IGI neuron projection extension

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000012485 aurka aurora kinase A protein_coding Danio_rerio
ENSG00000087586 AURKA aurora kinase A protein_coding Homo_sapiens

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