C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: aurora kinase A
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000087586 AURKA 9606 - 20:56369389-56392337 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000312783 AURKA-004 56369390-56392295 protein_coding
  ENST00000347343 AURKA-001 56369390-56392205 protein_coding
  ENST00000371356 AURKA-005 56369390-56392196 protein_coding
  ENST00000395907 AURKA-011 56369665-56392215 protein_coding
  ENST00000395911 AURKA-010 56369390-56392215 protein_coding
  ENST00000395913 AURKA-006 56369390-56392337 protein_coding
  ENST00000395914 AURKA-201 56369389-56392295 protein_coding
  ENST00000395915 AURKA-003 56369390-56392296 protein_coding
  ENST00000420474 AURKA-009 56382985-56392267 protein_coding
  ENST00000422322 AURKA-008 56383111-56392131 protein_coding
  ENST00000441357 AURKA-002 56373448-56392215 protein_coding
  ENST00000451915 AURKA-012 56386337-56392202 protein_coding
  ENST00000456249 AURKA-007 56386257-56392220 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000312783ENST00000347343ENST00000371356ENST00000395907ENST00000395911ENST00000395913ENST00000395914ENST00000395915ENST00000420474ENST00000422322ENST00000441357ENST00000456249
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000312783 N/A N/A N/A N/A N/A N/A N/A 0.642±0.00 N/A N/A N/A 2.865±0.00 1.398±0.42 2.572±0.00
ENST00000347343 N/A 0.096±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.270±1.77 1.229±0.33 5.836±3.27
ENST00000371356 0.367±0.00 0.276±0.00 N/A 0.287±0.00 0.529±0.00 1.066±0.00 0.815±0.00 N/A 0.257±0.00 0.254±0.00 0.561±0.00 3.620±3.09 2.649±2.04 7.657±3.64
ENST00000395907 N/A N/A N/A N/A 0.179±0.00 N/A 0.333±0.00 0.177±0.00 N/A N/A N/A N/A N/A 6.497±0.00
ENST00000395911 N/A N/A N/A N/A N/A 0.676±0.00 N/A 1.697±0.00 0.327±0.00 N/A N/A 0.262±0.00 N/A N/A
ENST00000395913 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.254±0.83 0.681±0.00 2.467±0.00
ENST00000395914 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.517±0.00 N/A
ENST00000395915 0.058±0.00 N/A N/A 0.103±0.00 0.104±0.00 N/A 0.084±0.00 0.329±0.00 0.393±0.00 N/A N/A 2.712±1.38 1.736±1.06 3.850±0.00
ENST00000420474 N/A N/A N/A 0.368±0.00 N/A N/A 0.356±0.19 N/A N/A N/A 0.909±0.00 N/A N/A N/A
ENST00000422322 N/A N/A 0.585±0.00 N/A N/A N/A N/A N/A N/A N/A 0.848±0.00 N/A N/A N/A
ENST00000441357 N/A N/A N/A 0.539±0.00 0.807±0.00 N/A 0.179±0.00 N/A N/A N/A N/A 5.143±0.00 N/A 11.534±0.00
ENST00000456249 N/A 0.855±0.00 N/A N/A 0.811±0.00 0.537±0.00 N/A N/A N/A 0.539±0.00 N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00099D CIL_00099D_0001 VISTA 20:56155251-56756351
CIL_0001I0 CIL_0001I0_0001 CGP 20:56358915-56392337
CIL_0002PV CIL_0002PV_0001 CGP 20:56369389-56406369

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000086 TAS G2/M transition of mitotic cell cycle
GO:0000212 IEA meiotic spindle organization
GO:0000226 IEA microtubule cytoskeleton organization
GO:0000278 TAS mitotic cell cycle
GO:0004672 IDA:IEA protein kinase activity
GO:0004674 EXP protein serine/threonine kinase activity
GO:0004712 TAS protein serine/threonine/tyrosine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005813 IDA centrosome
GO:0005815 IEA microtubule organizing center
GO:0005819 TAS spindle
GO:0005829 TAS cytosol
GO:0005876 IDA spindle microtubule
GO:0006468 IDA:IEA protein phosphorylation
GO:0007052 IEA mitotic spindle organization
GO:0007057 IEA spindle assembly involved in female meiosis I
GO:0007067 TAS mitotic nuclear division
GO:0007100 IEA mitotic centrosome separation
GO:0007126 IEA meiotic nuclear division
GO:0009948 IEA anterior/posterior axis specification
GO:0015630 IDA microtubule cytoskeleton
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0019901 IPI protein kinase binding
GO:0030496 TAS midbody
GO:0031145 TAS anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031616 IDA spindle pole centrosome
GO:0031625 IEA ubiquitin protein ligase binding
GO:0031647 IMP regulation of protein stability
GO:0032091 IDA negative regulation of protein binding
GO:0032436 IEA positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0035174 IEA histone serine kinase activity
GO:0035404 IEA histone-serine phosphorylation
GO:0042585 IEA germinal vesicle
GO:0043066 IEA negative regulation of apoptotic process
GO:0043146 IMP spindle stabilization
GO:0043203 IEA axon hillock
GO:0045120 IEA pronucleus
GO:0045840 TAS positive regulation of mitosis
GO:0046605 TAS regulation of centrosome cycle
GO:0046777 TAS protein autophosphorylation
GO:0048471 IDA perinuclear region of cytoplasm
GO:0051297 IEA centrosome organization
GO:0051642 IEA centrosome localization
GO:0071539 IEA protein localization to centrosome
GO:0072686 IEA mitotic spindle
GO:0072687 IEA meiotic spindle
GO:0090233 IEA negative regulation of spindle checkpoint
GO:1900195 IEA positive regulation of oocyte maturation
GO:1990138 IEA neuron projection extension

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000012485 aurka aurora kinase A protein_coding Danio_rerio
ENSMUSG00000027496 Aurka aurora kinase A protein_coding Mus_musculus

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