C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: 5,10-methylenetetrahydrofolate reductase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000029009 Mthfr 10090 + 4:148039077-148059551 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000069604 Mthfr-001 148041191-148059551 protein_coding
  ENSMUST00000097788 Mthfr-003 148039077-148056206 protein_coding
  ENSMUST00000125978 Mthfr-007 148041602-148043956 retained_intron
  ENSMUST00000141283 Mthfr-002 148039159-148044554 protein_coding
  ENSMUST00000145115 Mthfr-006 148040810-148043448 retained_intron
  ENSMUST00000152498 Mthfr-005 148041287-148059551 nonsense_mediated_decay
  ENSMUST00000156113 Mthfr-004 148052678-148059548 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000069604ENSMUST00000097788ENSMUST00000141283ENSMUST00000156113
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000069604 7.011±1.56 7.177±0.93 6.252±1.00 5.621±3.61 5.250±2.81 2.357±0.78 1.740±0.84 7.566±1.68 3.321±2.10 7.908±0.74 0.759±0.19 7.187±2.54 5.611±2.31 5.776±1.88
ENSMUST00000097788 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.406±1.60
ENSMUST00000141283 N/A N/A N/A N/A N/A N/A N/A N/A 3.920±0.00 N/A N/A N/A N/A N/A
ENSMUST00000156113 3.647±0.32 5.181±0.95 2.767±0.24 3.834±0.00 4.374±0.58 2.594±0.37 1.588±0.58 5.185±0.11 2.411±0.75 4.913±0.75 N/A 6.887±2.03 3.123±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00087H CIL_00087H_0002 VISTA 4:147665245-148272946

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001666 IEA response to hypoxia
GO:0004489 IMP methylenetetrahydrofolate reductase (NAD(P)H) activity
GO:0005829 IEA cytosol
GO:0009086 IMP methionine biosynthetic process
GO:0033274 IEA response to vitamin B2
GO:0035999 IEA tetrahydrofolate interconversion
GO:0042493 IEA response to drug
GO:0043005 IEA neuron projection
GO:0043200 IEA response to amino acid
GO:0046500 IEA S-adenosylmethionine metabolic process
GO:0046653 IEA tetrahydrofolate metabolic process
GO:0050660 IEA flavin adenine dinucleotide binding
GO:0050661 IEA NADP binding
GO:0050667 IEA homocysteine metabolic process
GO:0051593 IEA response to folic acid
GO:0055114 IEA oxidation-reduction process
GO:0070555 IEA response to interleukin-1
GO:0072341 IEA modified amino acid binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000053087 mthfr methylenetetrahydrofolate reductase (NAD(P)H) protein_coding Danio_rerio
ENSG00000177000 MTHFR methylenetetrahydrofolate reductase (NAD(P)H) protein_coding Homo_sapiens

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