C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: checkpoint kinase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000029521 Chek2 10090 + 5:110840017-110874133 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000066160 Chek2-201 110840017-110874133 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000066160
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000066160 2.999±0.50 3.407±1.35 2.365±0.40 1.500±0.96 2.556±0.79 3.887±1.98 0.746±0.27 1.549±0.69 6.801±6.90 1.649±0.77 0.418±0.19 4.175±1.51 2.267±1.65 0.582±0.25

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008NO CIL_0008NO_0002 VISTA 5:110598210-111198771
CIL_0007W4 CIL_0007W4_0002 VISTA 5:110754482-111355796

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000077 IEA DNA damage checkpoint
GO:0000086 ISS G2/M transition of mitotic cell cycle
GO:0000781 IEA chromosome, telomeric region
GO:0004674 ISS protein serine/threonine kinase activity
GO:0005524 IEA ATP binding
GO:0006302 ISS double-strand break repair
GO:0006351 IEA transcription, DNA-templated
GO:0006355 ISS regulation of transcription, DNA-templated
GO:0006915 IMP apoptotic process
GO:0006974 ISS cellular response to DNA damage stimulus
GO:0006975 ISS DNA damage induced protein phosphorylation
GO:0008630 ISS intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010332 IDA response to gamma radiation
GO:0016301 IEA kinase activity
GO:0016605 ISS PML body
GO:0019901 IEA protein kinase binding
GO:0031625 IEA ubiquitin protein ligase binding
GO:0042176 ISS regulation of protein catabolic process
GO:0042770 IDA signal transduction in response to DNA damage
GO:0042802 IEA identical protein binding
GO:0042803 ISS protein homodimerization activity
GO:0044257 IEA cellular protein catabolic process
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0046777 ISS protein autophosphorylation
GO:0046872 IEA metal ion binding
GO:0050821 IEA protein stabilization
GO:0072428 ISS signal transduction involved in intra-S DNA damage checkpoint
GO:0090307 ISS spindle assembly involved in mitosis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000025820 chek2 CHK2 checkpoint homolog (S. pombe) protein_coding Danio_rerio
ENSG00000183765 CHEK2 checkpoint kinase 2 protein_coding Homo_sapiens

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