C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: checkpoint kinase 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000066160 Chek2-201 ENSMUSG00000029521 10090 + 5:110840017-110874133 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000066160
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000066160 2.999±0.50 3.407±1.35 2.365±0.40 1.500±0.96 2.556±0.79 3.887±1.98 0.746±0.27 1.549±0.69 6.801±6.90 1.649±0.77 0.418±0.19 4.175±1.51 2.267±1.65 0.582±0.25

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008NO CIL_0008NO_0002 VISTA 5:110598210-111198771
CIL_0007W4 CIL_0007W4_0002 VISTA 5:110754482-111355796

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000077 IEA DNA damage checkpoint
GO:0000086 ISS G2/M transition of mitotic cell cycle
GO:0000781 IEA chromosome, telomeric region
GO:0004674 ISS protein serine/threonine kinase activity
GO:0005524 IEA ATP binding
GO:0006302 ISS double-strand break repair
GO:0006351 IEA transcription, DNA-templated
GO:0006355 ISS regulation of transcription, DNA-templated
GO:0006915 IMP apoptotic process
GO:0006974 ISS cellular response to DNA damage stimulus
GO:0006975 ISS DNA damage induced protein phosphorylation
GO:0008630 ISS intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010332 IDA response to gamma radiation
GO:0016301 IEA kinase activity
GO:0016605 ISS PML body
GO:0019901 IEA protein kinase binding
GO:0031625 IEA ubiquitin protein ligase binding
GO:0042176 ISS regulation of protein catabolic process
GO:0042770 IDA signal transduction in response to DNA damage
GO:0042802 IEA identical protein binding
GO:0042803 ISS protein homodimerization activity
GO:0044257 IEA cellular protein catabolic process
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0046777 ISS protein autophosphorylation
GO:0046872 IEA metal ion binding
GO:0050821 IEA protein stabilization
GO:0072428 ISS signal transduction involved in intra-S DNA damage checkpoint
GO:0090307 ISS spindle assembly involved in mitosis

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000328354 CHEK2-002 protein_coding Homo_sapiens 0 1476
ENST00000348295 CHEK2-201 protein_coding Homo_sapiens 0 935
ENST00000382580 CHEK2-003 protein_coding Homo_sapiens 0 1317
ENST00000402731 CHEK2-022 protein_coding Homo_sapiens 0 935
ENST00000403642 CHEK2-021 protein_coding Homo_sapiens 0 1027
ENST00000404276 CHEK2-006 protein_coding Homo_sapiens 0 1476
ENST00000405598 CHEK2-005 protein_coding Homo_sapiens 0 1476
ENST00000416671 CHEK2-001 nonsense_mediated_decay Homo_sapiens 0 1029
ENST00000417588 CHEK2-009 nonsense_mediated_decay Homo_sapiens 0 880
ENST00000425190 CHEK2-011 protein_coding Homo_sapiens 0 797
ENST00000433028 CHEK2-004 nonsense_mediated_decay Homo_sapiens 0 562
ENST00000433728 CHEK2-023 nonsense_mediated_decay Homo_sapiens 0 769
ENST00000434810 CHEK2-018 protein_coding Homo_sapiens 0 484
ENST00000439200 CHEK2-013 protein_coding Homo_sapiens 0 555
ENST00000448511 CHEK2-008 nonsense_mediated_decay Homo_sapiens 0 1026
ENST00000554701 CHEK2P2-001 transcribed_unprocessed_pseudogene Homo_sapiens 1e-39 167
ENST00000555186 CHEK2P2-002 processed_transcript Homo_sapiens 9.99995e-41 171
ENST00000566448 CHEK2P2-003 processed_transcript Homo_sapiens 4.00001e-40 169
ENST00000567422 RP11-23E10.4-001 transcribed_unprocessed_pseudogene Homo_sapiens 0 309

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