C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: eukaryotic translation initiation factor 2 alpha kinase 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000100487 Eif2ak1-001 ENSMUSG00000029613 10090 + 5:143817788-143904256 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000100487
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000100487 9.220±1.69 17.662±4.58 4.882±2.19 15.545±4.40 10.814±1.61 16.838±1.83 5.586±0.64 15.546±1.39 23.512±17.48 9.627±2.44 8.157±3.48 14.526±4.04 12.069±8.42 9.723±1.01

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005BI CIL_0005BI_0002 CGP 5:143710325-143904256
CIL_0002VB CIL_0002VB_0002 CGP 5:143817788-143904256

Gene Ontology

GO IDEvidence TypeGO Description
GO:0004672 IMP protein kinase activity
GO:0004694 ISS eukaryotic translation initiation factor 2alpha kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005737 IDA cytoplasm
GO:0006417 IMP regulation of translation
GO:0006950 ISS response to stress
GO:0008285 IDA negative regulation of cell proliferation
GO:0009605 ISS response to external stimulus
GO:0010999 IGI regulation of eIF2 alpha phosphorylation by heme
GO:0017148 IEA negative regulation of translation
GO:0020037 IDA heme binding
GO:0042803 IPI protein homodimerization activity
GO:0046501 IGI protoporphyrinogen IX metabolic process
GO:0046777 IEP protein autophosphorylation
GO:0046984 IGI regulation of hemoglobin biosynthetic process
GO:0046986 IDA negative regulation of hemoglobin biosynthetic process

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000199389 EIF2AK1-001 protein_coding Homo_sapiens 0 1707
ENST00000223029 AIMP2-001 protein_coding Homo_sapiens 0 355
ENST00000395236 AIMP2-004 protein_coding Homo_sapiens 0 355
ENST00000400479 AIMP2-003 protein_coding Homo_sapiens 0 355
ENST00000422786 EIF2AK1-011 protein_coding Homo_sapiens 0 366
ENST00000481134 RP11-383G6.4-001 processed_pseudogene Homo_sapiens 0 944
ENST00000513291 ATR-002 protein_coding Homo_sapiens 0 944

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