C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: killer cell lectin-like receptor subfamily K, member 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000030149 Klrk1 10090 - 6:129610323-129623864 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000032252 Klrk1-001 129612414-129622772 protein_coding
  ENSMUST00000095412 Klrk1-002 129610323-129623864 protein_coding
  ENSMUST00000137660 Klrk1-004 129616568-129622684 retained_intron
  ENSMUST00000152256 Klrk1-003 129616493-129622581 retained_intron
  ENSMUST00000168919 Klrk1-201 129610323-129623864 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000032252ENSMUST00000095412ENSMUST00000137660ENSMUST00000152256ENSMUST00000168919
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000032252 0.330±0.00 0.268±0.12 0.590±0.01 N/A 0.525±0.15 0.179±0.06 0.026±0.00 0.110±0.04 0.154±0.09 0.452±0.11 0.068±0.09 0.299±0.17 0.112±0.03 N/A
ENSMUST00000095412 0.204±0.04 0.031±0.00 0.200±0.06 0.020±0.02 0.343±0.00 0.064±0.04 0.085±0.05 0.071±0.04 0.091±0.04 0.326±0.00 0.033±0.03 0.087±0.05 0.020±0.02 0.014±0.01
ENSMUST00000137660 0.396±0.00 N/A N/A N/A 1.403±0.00 N/A 0.144±0.07 0.199±0.00 0.435±0.00 N/A 0.105±0.00 0.344±0.00 N/A N/A
ENSMUST00000152256 N/A N/A N/A N/A N/A N/A 0.034±0.00 0.119±0.07 0.201±0.00 N/A N/A N/A N/A N/A
ENSMUST00000168919 N/A 0.031±0.00 N/A 0.002±0.00 0.358±0.00 0.060±0.03 0.007±0.00 0.031±0.02 0.046±0.02 0.181±0.06 N/A 0.052±0.02 0.002±0.00 0.014±0.01

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00054H CIL_00054H_0002 CGP 6:129591782-129623864
CIL_0000T5 CIL_0000T5_0002 CGP 6:129610323-129643337

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002223 IMP stimulatory C-type lectin receptor signaling pathway
GO:0005515 IPI protein binding
GO:0005886 TAS plasma membrane
GO:0009897 IDA external side of plasma membrane
GO:0009986 IDA cell surface
GO:0016021 IEA integral component of membrane
GO:0019900 IPI kinase binding
GO:0030101 IMP natural killer cell activation
GO:0030154 IEA cell differentiation
GO:0030246 IEA carbohydrate binding
GO:0032394 IMP MHC class Ib receptor activity
GO:0032729 IDA positive regulation of interferon-gamma production
GO:0042288 IPI MHC class I protein binding
GO:0042803 IDA protein homodimerization activity
GO:0045087 IEA innate immune response
GO:0045429 IDA positive regulation of nitric oxide biosynthetic process
GO:0045954 IMP positive regulation of natural killer cell mediated cytotoxicity
GO:0050830 IDA defense response to Gram-positive bacterium
GO:0071222 IDA cellular response to lipopolysaccharide

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000213809 KLRK1 killer cell lectin-like receptor subfamily K, member 1 protein_coding Homo_sapiens
ENSG00000255819 KLRC4-KLRK1 KLRC4-KLRK1 readthrough protein_coding Homo_sapiens

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