C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: proprotein convertase subtilisin/kexin type 6
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000030513 Pcsk6 10090 + 7:65861734-66050340 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000055576 Pcsk6-001 65862029-66050335 protein_coding
  ENSMUST00000098391 Pcsk6-002 65862136-66050334 protein_coding
  ENSMUST00000176199 Pcsk6-004 65861734-65952984 protein_coding
  ENSMUST00000176209 Pcsk6-003 65862432-66050340 protein_coding
  ENSMUST00000177272 Pcsk6-006 66038418-66043528 retained_intron
  ENSMUST00000177369 Pcsk6-005 65953012-65963193 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000055576ENSMUST00000098391ENSMUST00000176209
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000055576 9.980±5.24 0.727±0.00 N/A 1.384±1.54 4.059±2.46 N/A 5.530±1.30 4.709±1.48 2.344±1.59 0.663±0.07 0.518±0.01 2.680±0.82 6.534±5.13 0.345±0.00
ENSMUST00000098391 6.510±2.65 4.034±0.81 1.586±0.32 1.038±0.16 8.948±2.85 6.482±0.62 7.443±1.62 4.752±2.39 7.276±5.88 3.509±0.70 0.934±0.25 9.915±2.28 2.782±1.25 0.956±0.29
ENSMUST00000176209 N/A 1.137±0.52 0.742±0.07 0.652±0.01 5.924±0.00 1.910±0.65 N/A 2.995±1.07 6.015±4.01 N/A 1.193±0.57 4.782±4.19 3.666±4.21 0.077±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007CP CIL_0007CP_0002 CGP 7:65861734-66074582

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004175 IEA endopeptidase activity
GO:0004252 IBA serine-type endopeptidase activity
GO:0005615 IBA extracellular space
GO:0005794 IBA Golgi apparatus
GO:0006508 IEA proteolysis
GO:0007354 IGI zygotic determination of anterior/posterior axis, embryo
GO:0007368 IGI determination of left/right symmetry
GO:0008201 IEA heparin binding
GO:0009100 IEA glycoprotein metabolic process
GO:0009986 IEA cell surface
GO:0016485 IBA protein processing
GO:0016486 IEA peptide hormone processing
GO:0031012 IEA extracellular matrix
GO:0032902 IEA nerve growth factor production
GO:0032940 IEA secretion by cell
GO:0048406 IEA nerve growth factor binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000090857 PCSK6 proprotein convertase subtilisin/kexin type 6 protein_coding Danio_rerio
ENSG00000140479 PCSK6 proprotein convertase subtilisin/kexin type 6 protein_coding Homo_sapiens

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