C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: proprotein convertase subtilisin/kexin type 6
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000140479 PCSK6 9606 - 15:101297142-101525202 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000331826 PCSK6-201 101364908-101489984 protein_coding
  ENST00000398185 PCSK6-008 101303929-101443663 protein_coding
  ENST00000557794 PCSK6-009 101304746-101525202 processed_transcript
  ENST00000558154 PCSK6-007 101365785-101382206 retained_intron
  ENST00000558433 PCSK6-015 101305128-101316389 processed_transcript
  ENST00000558864 PCSK6-011 101297142-101313402 protein_coding
  ENST00000558951 PCSK6-012 101300613-101366262 protein_coding
  ENST00000559417 PCSK6-010 101384322-101489435 protein_coding
  ENST00000559430 PCSK6-013 101305231-101308940 processed_transcript
  ENST00000559499 PCSK6-006 101303931-101309112 retained_intron
  ENST00000559605 PCSK6-017 101324939-101370468 protein_coding
  ENST00000560785 PCSK6-014 101307291-101313847 retained_intron
  ENST00000560902 PCSK6-018 101326381-101382124 processed_transcript
  ENST00000611716 PCSK6-001 101303928-101489839 protein_coding
  ENST00000611967 PCSK6-002 101346373-101489697 protein_coding
  ENST00000615296 PCSK6-019 101346742-101489697 protein_coding
  ENST00000618548 PCSK6-005 101303934-101489744 protein_coding
  ENST00000619160 PCSK6-004 101313017-101489744 protein_coding
  ENST00000621185 PCSK6-016 101364874-101370488 protein_coding
  ENST00000622483 PCSK6-003 101313017-101489744 protein_coding

Homo sapiens EnsemblGRCh38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000331826ENST00000398185ENST00000558433ENST00000558864ENST00000611716ENST00000618548ENST00000619160
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000331826 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 17.527±0.00 N/A
ENST00000398185 N/A 2.029±0.00 N/A N/A N/A 0.937±0.29 N/A N/A 0.386±0.00 N/A N/A N/A N/A 1.792±0.00
ENST00000558433 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 10.211±0.00
ENST00000558864 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.257±0.00 N/A N/A N/A N/A
ENST00000611716 N/A N/A N/A 7.089±4.82 N/A 1.095±0.00 2.459±0.00 13.377±12.08 42.108±0.00 0.163±0.00 N/A 1.734±0.35 10.238±1.16 N/A
ENST00000618548 0.818±0.00 3.437±0.00 0.247±0.00 7.302±5.93 2.220±0.00 1.061±0.44 6.079±0.00 0.617±0.00 38.175±0.00 2.415±0.00 2.476±2.35 4.752±0.02 13.115±2.25 2.834±0.32
ENST00000619160 N/A N/A 0.409±0.00 N/A N/A N/A N/A N/A 0.207±0.00 N/A N/A N/A N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004175 IDA endopeptidase activity
GO:0004252 IEA serine-type endopeptidase activity
GO:0005515 IEA protein binding
GO:0005615 IDA extracellular space
GO:0005783 IEA endoplasmic reticulum
GO:0005796 TAS Golgi lumen
GO:0006508 IEA proteolysis
GO:0007354 IEA zygotic determination of anterior/posterior axis, embryo
GO:0007368 IEA determination of left/right symmetry
GO:0008201 IDA heparin binding
GO:0008233 IEA peptidase activity
GO:0009100 IDA glycoprotein metabolic process
GO:0009986 IDA cell surface
GO:0016020 IEA membrane
GO:0016485 IDA protein processing
GO:0016486 IDA peptide hormone processing
GO:0030510 TAS regulation of BMP signaling pathway
GO:0031012 IDA extracellular matrix
GO:0032455 TAS nerve growth factor processing
GO:0032902 IDA nerve growth factor production
GO:0032940 IDA secretion by cell
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048406 IDA nerve growth factor binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000090857 PCSK6 proprotein convertase subtilisin/kexin type 6 protein_coding Danio_rerio
ENSMUSG00000030513 Pcsk6 proprotein convertase subtilisin/kexin type 6 protein_coding Mus_musculus

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