C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: furin (paired basic amino acid cleaving enzyme)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000030530 Furin 10090 - 7:80388585-80405436 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000107362 Furin-201 80389194-80405431 protein_coding
  ENSMUST00000120753 Furin-002 80389196-80401707 protein_coding
  ENSMUST00000122232 Furin-001 80389194-80402762 protein_coding
  ENSMUST00000135306 Furin-005 80398594-80405436 protein_coding
  ENSMUST00000146771 Furin-004 80388585-80396353 retained_intron
  ENSMUST00000147150 Furin-006 80398641-80403322 protein_coding
  ENSMUST00000153446 Furin-003 80396310-80399469 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000107362ENSMUST00000122232ENSMUST00000146771ENSMUST00000153446
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000107362 12.653±4.03 41.977±10.11 7.969±1.67 3.250±0.22 19.993±10.81 22.305±1.62 14.532±4.41 42.821±8.83 22.210±19.34 31.190±9.54 N/A 41.714±8.72 16.810±8.23 2.298±0.41
ENSMUST00000122232 4.098±0.00 42.017±11.48 8.001±0.63 5.407±0.00 9.072±3.73 11.159±4.82 6.900±0.90 16.343±2.81 10.900±8.68 N/A 10.637±1.70 14.604±4.09 19.085±11.43 0.429±0.00
ENSMUST00000146771 N/A N/A N/A N/A 0.806±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000153446 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.152±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008AY CIL_0008AY_0002 VISTA 7:80145068-80746500

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002020 IEA protease binding
GO:0004175 IEA endopeptidase activity
GO:0004252 IBA serine-type endopeptidase activity
GO:0004867 IEA serine-type endopeptidase inhibitor activity
GO:0005515 IPI protein binding
GO:0005576 TAS extracellular region
GO:0005615 IBA extracellular space
GO:0005769 TAS early endosome
GO:0005788 TAS endoplasmic reticulum lumen
GO:0005794 IBA Golgi apparatus
GO:0005802 IEA trans-Golgi network
GO:0005886 IEA plasma membrane
GO:0006465 IEA signal peptide processing
GO:0006508 IBA:IEA proteolysis
GO:0008233 ISO peptidase activity
GO:0008283 IEA cell proliferation
GO:0009966 IDA regulation of signal transduction
GO:0009986 IEA cell surface
GO:0010951 IEA negative regulation of endopeptidase activity
GO:0012510 TAS trans-Golgi network transport vesicle membrane
GO:0016020 IEA membrane
GO:0016021 TAS integral component of membrane
GO:0016485 ISO protein processing
GO:0016486 IEA peptide hormone processing
GO:0019058 IEA viral life cycle
GO:0030140 ISO trans-Golgi network transport vesicle
GO:0032804 IEA negative regulation of low-density lipoprotein particle receptor catabolic process
GO:0032902 IEA nerve growth factor production
GO:0032911 IEA negative regulation of transforming growth factor beta1 production
GO:0032940 IEA secretion by cell
GO:0042176 IEA regulation of protein catabolic process
GO:0042277 IEA peptide binding
GO:0043043 IEA peptide biosynthetic process
GO:0045121 IEA membrane raft
GO:0046872 IEA metal ion binding
GO:0048406 IEA nerve growth factor binding
GO:0052548 IEA regulation of endopeptidase activity
GO:0070062 IEA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000062909 furina furin (paired basic amino acid cleaving enzyme) a protein_coding Danio_rerio
ENSDARG00000070971 furinb furin (paired basic amino acid cleaving enzyme) b protein_coding Danio_rerio
ENSG00000140564 FURIN furin (paired basic amino acid cleaving enzyme) protein_coding Homo_sapiens

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