C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: adrenergic receptor, beta 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000031489 Adrb3 10090 - 8:27225776-27229588 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000081438 Adrb3-001 27225776-27229588 protein_coding
  ENSMUST00000117565 Adrb3-002 27226799-27228494 protein_coding
  ENSMUST00000121838 Adrb3-003 27226001-27228583 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000081438ENSMUST00000117565ENSMUST00000121838
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000081438 43.499±28.78 N/A 3.804±0.00 0.171±0.00 32.325±4.26 0.829±0.14 0.591±0.15 1.564±0.18 0.239±0.30 2.882±0.73 0.099±0.04 3.710±1.22 0.063±0.00 0.030±0.00
ENSMUST00000117565 196.162±101.29 142.479±75.48 N/A 0.135±0.05 317.974±11.63 4.793±1.13 5.062±3.63 10.742±3.08 0.735±0.99 19.943±5.96 0.076±0.00 34.605±8.44 1.340±1.07 0.106±0.05
ENSMUST00000121838 124.665±44.23 78.390±22.77 4.790±0.62 0.146±0.11 143.214±30.06 4.048±1.24 2.454±1.30 8.352±1.77 0.474±0.55 11.985±3.31 0.254±0.23 14.154±4.47 0.518±0.69 0.048±0.01

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0009C5 CIL_0009C5_0002 VISTA 8:26806327-27408431
CIL_0007QT CIL_0007QT_0002 VISTA 8:26806345-27408424
CIL_00009T CIL_00009T_0002 CGP 8:27197460-27229588
CIL_0002IS CIL_0002IS_0002 CGP 8:27225776-27275656

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002024 IGI diet induced thermogenesis
GO:0002025 IDA vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
GO:0004939 ISS beta-adrenergic receptor activity
GO:0005515 IEA protein binding
GO:0005634 IEA nucleus
GO:0005886 IEA plasma membrane
GO:0007189 IDA adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007190 ISS activation of adenylate cyclase activity
GO:0007568 IEA aging
GO:0009409 IGI response to cold
GO:0015052 ISS beta3-adrenergic receptor activity
GO:0016020 IDA membrane
GO:0016021 IEA integral component of membrane
GO:0031649 IGI heat generation
GO:0031699 IDA beta-3 adrenergic receptor binding
GO:0040015 IGI negative regulation of multicellular organism growth
GO:0042755 IEA eating behavior
GO:0042803 ISS protein homodimerization activity
GO:0043235 ISS receptor complex
GO:0043410 ISS positive regulation of MAPK cascade
GO:0046677 IEA response to antibiotic
GO:0050873 IGI brown fat cell differentiation
GO:0051379 IEA epinephrine binding
GO:0051380 ISS norepinephrine binding
GO:0071875 IEA adrenergic receptor signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000052919 adrb3b adrenergic receptor, beta 3b protein_coding Danio_rerio
ENSDARG00000053646 adrb3a adrenergic receptor, beta 3a protein_coding Danio_rerio
ENSG00000188778 ADRB3 adrenoceptor beta 3 protein_coding Homo_sapiens

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