C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: fibroblast growth factor receptor 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000031565 Fgfr1 10090 + 8:25513654-25575714 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000084027 Fgfr1-001 25518792-25575714 protein_coding
  ENSMUST00000117179 Fgfr1-002 25518795-25574781 protein_coding
  ENSMUST00000119398 Fgfr1-003 25519319-25574779 protein_coding
  ENSMUST00000120106 Fgfr1-015 25566850-25574784 retained_intron
  ENSMUST00000124228 Fgfr1-013 25519837-25555729 protein_coding
  ENSMUST00000126118 Fgfr1-011 25563405-25574785 retained_intron
  ENSMUST00000133936 Fgfr1-010 25569723-25572457 retained_intron
  ENSMUST00000138104 Fgfr1-007 25555617-25570206 processed_transcript
  ENSMUST00000138455 Fgfr1-008 25558074-25563714 retained_intron
  ENSMUST00000145218 Fgfr1-009 25569486-25572395 retained_intron
  ENSMUST00000148322 Fgfr1-014 25518895-25555658 processed_transcript
  ENSMUST00000155564 Fgfr1-012 25513654-25555568 protein_coding
  ENSMUST00000167764 Fgfr1-005 25532281-25574577 protein_coding
  ENSMUST00000178276 Fgfr1-201 25518772-25575714 protein_coding
  ENSMUST00000179592 Fgfr1-202 25518772-25575714 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaENSMUST00000084027ENSMUST00000117179ENSMUST00000119398ENSMUST00000120106ENSMUST00000126118ENSMUST00000167764ENSMUST00000178276
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta
ENSMUST00000084027 4.581±0.89 N/A 4.151±0.98 2.718±1.16 N/A 2.360±0.66 1.065±0.13 2.479±0.79 0.143±0.05 2.859±0.15 3.113±0.74 2.826±0.36 5.823±4.06
ENSMUST00000117179 13.592±0.53 31.120±4.53 9.450±1.91 6.891±3.43 17.966±6.77 6.611±1.43 2.362±0.72 4.230±1.02 0.354±0.17 6.276±0.92 5.689±1.34 9.493±3.68 10.762±2.62
ENSMUST00000119398 10.582±4.30 N/A 9.925±2.73 6.485±0.00 13.742±1.91 4.029±0.43 4.017±1.02 6.223±1.39 0.235±0.11 6.846±2.28 4.757±0.44 7.285±2.35 16.048±8.91
ENSMUST00000120106 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.197±0.48 N/A N/A
ENSMUST00000126118 5.652±0.00 N/A N/A 4.073±1.02 13.350±2.59 2.756±0.00 1.804±0.35 2.588±0.06 0.177±0.05 4.693±0.36 5.749±1.14 4.914±1.78 11.978±11.70
ENSMUST00000167764 N/A N/A N/A 3.303±0.00 13.323±2.48 4.682±1.02 2.831±0.00 N/A 0.273±0.14 N/A 3.672±0.00 5.635±1.23 21.058±10.28
ENSMUST00000178276 N/A 10.388±1.57 N/A N/A 7.752±0.49 N/A N/A N/A 0.069±0.00 N/A N/A 2.611±0.86 4.447±1.68

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008D9 CIL_0008D9_0002 VISTA 8:25042689-25644335
CIL_0008H7 CIL_0008H7_0002 VISTA 8:25139932-25741457
CIL_0008SM CIL_0008SM_0002 VISTA 8:25140188-25742103
CIL_0008NR CIL_0008NR_0002 VISTA 8:25243011-25845762

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0001525 IGI angiogenesis
GO:0001657 IGI ureteric bud development
GO:0001701 IGI in utero embryonic development
GO:0001759 IMP organ induction
GO:0002053 IGI positive regulation of mesenchymal cell proliferation
GO:0002062 IGI chondrocyte differentiation
GO:0005007 IDA fibroblast growth factor-activated receptor activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005886 ISS plasma membrane
GO:0007420 IMP brain development
GO:0007435 IMP salivary gland morphogenesis
GO:0007605 IMP sensory perception of sound
GO:0008201 ISS heparin binding
GO:0008284 IGI positive regulation of cell proliferation
GO:0008543 IGI fibroblast growth factor receptor signaling pathway
GO:0010468 IMP regulation of gene expression
GO:0010629 IMP negative regulation of gene expression
GO:0010863 ISS positive regulation of phospholipase C activity
GO:0010976 IGI positive regulation of neuron projection development
GO:0016021 IEA integral component of membrane
GO:0017134 ISS fibroblast growth factor binding
GO:0018108 ISS peptidyl-tyrosine phosphorylation
GO:0021769 IMP orbitofrontal cortex development
GO:0021847 IMP ventricular zone neuroblast division
GO:0030324 IMP lung development
GO:0030326 IMP embryonic limb morphogenesis
GO:0030901 IGI midbrain development
GO:0031410 IEA cytoplasmic vesicle
GO:0035607 IMP fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
GO:0042127 IMP regulation of cell proliferation
GO:0042472 IMP inner ear morphogenesis
GO:0042473 IMP outer ear morphogenesis
GO:0042474 IMP middle ear morphogenesis
GO:0042802 IEA identical protein binding
GO:0042803 IEA protein homodimerization activity
GO:0043235 ISO receptor complex
GO:0043406 ISS positive regulation of MAP kinase activity
GO:0043410 IEA positive regulation of MAPK cascade
GO:0045666 ISS positive regulation of neuron differentiation
GO:0045787 IMP positive regulation of cell cycle
GO:0046777 ISS protein autophosphorylation
GO:0048339 IGI paraxial mesoderm development
GO:0048378 IGI regulation of lateral mesodermal cell fate specification
GO:0048469 IMP cell maturation
GO:0048514 IMP blood vessel morphogenesis
GO:0048699 IMP generation of neurons
GO:0048762 IGI mesenchymal cell differentiation
GO:0060045 IGI positive regulation of cardiac muscle cell proliferation
GO:0060117 IMP auditory receptor cell development
GO:0060445 IMP branching involved in salivary gland morphogenesis
GO:0060484 IGI lung-associated mesenchyme development
GO:0060665 IDA regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0060979 TAS vasculogenesis involved in coronary vascular morphogenesis
GO:0090080 IGI positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:2001239 IMP regulation of extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000011027 fgfr1a fibroblast growth factor receptor 1a protein_coding Danio_rerio
ENSDARG00000011190 fgfr1b fibroblast growth factor receptor 1b protein_coding Danio_rerio
ENSDARG00000075027 fgfr1bl fibroblast growth factor receptor 1b, like protein_coding Danio_rerio
ENSG00000077782 FGFR1 fibroblast growth factor receptor 1 protein_coding Homo_sapiens

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