C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: fibroblast growth factor receptor 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000077782 FGFR1 9606 - 8:38411138-38468834 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000326324 FGFR1-008 38412732-38468616 protein_coding
  ENST00000335922 FGFR1-003 38412731-38468621 protein_coding
  ENST00000341462 FGFR1-201 38419533-38468834 protein_coding
  ENST00000356207 FGFR1-004 38412730-38468616 protein_coding
  ENST00000397090 FGFR1-033 38429521-38468150 retained_intron
  ENST00000397091 FGFR1-001 38411138-38468641 protein_coding
  ENST00000397103 FGFR1-011 38412934-38457503 protein_coding
  ENST00000397108 FGFR1-020 38413522-38467724 protein_coding
  ENST00000397113 FGFR1-012 38412728-38467900 protein_coding
  ENST00000413133 FGFR1-015 38429720-38467712 protein_coding
  ENST00000425967 FGFR1-202 38411138-38467845 protein_coding
  ENST00000434187 FGFR1-016 38428363-38466695 protein_coding
  ENST00000440174 FGFR1-019 38457442-38463400 protein_coding
  ENST00000447712 FGFR1-203 38411139-38468834 protein_coding
  ENST00000464163 FGFR1-013 38422744-38424621 retained_intron
  ENST00000466021 FGFR1-023 38417313-38422044 retained_intron
  ENST00000470826 FGFR1-005 38423313-38468308 retained_intron
  ENST00000474970 FGFR1-014 38426127-38429811 retained_intron
  ENST00000475621 FGFR1-022 38421708-38426181 retained_intron
  ENST00000480571 FGFR1-018 38465514-38466196 processed_transcript
  ENST00000484370 FGFR1-009 38426179-38457446 nonsense_mediated_decay
  ENST00000487647 FGFR1-010 38415993-38457446 nonsense_mediated_decay
  ENST00000496296 FGFR1-006 38424017-38468635 retained_intron
  ENST00000496629 FGFR1-017 38465413-38466663 processed_transcript
  ENST00000524528 FGFR1-032 38417953-38418674 retained_intron
  ENST00000525001 FGFR1-036 38424549-38467842 protein_coding
  ENST00000526570 FGFR1-024 38412848-38430820 retained_intron
  ENST00000526688 FGFR1-031 38412085-38413976 processed_transcript
  ENST00000526742 FGFR1-038 38426158-38467804 protein_coding
  ENST00000527114 FGFR1-025 38414779-38420344 retained_intron
  ENST00000527203 FGFR1-035 38424528-38457476 processed_transcript
  ENST00000527745 FGFR1-026 38417407-38420044 retained_intron
  ENST00000529552 FGFR1-037 38426174-38467845 protein_coding
  ENST00000530568 FGFR1-027 38428012-38466663 protein_coding
  ENST00000530701 FGFR1-029 38421843-38457532 processed_transcript
  ENST00000531196 FGFR1-039 38413466-38415923 nonsense_mediated_decay
  ENST00000532386 FGFR1-034 38424683-38430002 retained_intron
  ENST00000532791 FGFR1-002 38411231-38468622 protein_coding
  ENST00000533619 FGFR1-030 38414613-38417514 retained_intron
  ENST00000533668 FGFR1-028 38424546-38467707 protein_coding
  ENST00000619564 FGFR1-204 38419533-38468834 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000326324ENST00000356207ENST00000397091ENST00000397103ENST00000397108ENST00000397113ENST00000447712ENST00000466021ENST00000470826ENST00000526570ENST00000526742ENST00000527114ENST00000527203ENST00000532791ENST00000533668
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000326324 31.159±0.00 9.320±0.00 N/A 3.066±0.00 20.409±0.00 20.296±0.00 9.813±0.00 8.063±0.00 4.818±2.48 17.968±15.94 4.606±0.00 17.228±22.04 18.448±4.43 6.505±0.00
ENST00000356207 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.506±0.00 5.580±3.87 12.829±1.09 N/A
ENST00000397091 N/A N/A N/A 1.863±0.24 N/A 2.681±0.00 2.555±1.12 N/A 2.098±1.68 1.221±0.00 N/A 15.408±0.00 N/A N/A
ENST00000397103 N/A 8.267±0.00 N/A N/A 12.969±8.30 12.594±0.00 N/A 6.312±0.00 N/A 21.955±0.00 N/A 21.017±0.00 15.324±6.26 13.457±0.00
ENST00000397108 N/A N/A N/A 4.335±0.00 N/A N/A 3.339±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000397113 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 15.833±0.00 11.192±0.00 9.803±0.00
ENST00000447712 N/A N/A N/A N/A 2.090±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000466021 N/A N/A 6.336±0.00 N/A 21.018±0.00 21.034±0.00 N/A 1.687±0.00 39.840±0.00 14.669±0.00 5.461±0.00 13.485±0.89 89.769±0.00 49.083±0.00
ENST00000470826 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.149±0.00 N/A N/A N/A
ENST00000526570 N/A N/A 0.653±0.00 N/A N/A N/A N/A N/A N/A 1.103±0.00 N/A 1.188±0.00 N/A N/A
ENST00000526742 N/A N/A 4.760±0.00 N/A N/A N/A N/A 0.896±0.00 N/A N/A N/A N/A N/A N/A
ENST00000527114 N/A N/A 2.526±0.00 N/A N/A N/A N/A 0.641±0.00 N/A N/A 2.086±0.00 N/A N/A N/A
ENST00000527203 N/A N/A N/A N/A N/A N/A N/A N/A N/A 9.716±0.00 N/A N/A N/A N/A
ENST00000532791 N/A 7.071±0.00 N/A 3.179±0.00 13.836±0.00 9.489±0.00 5.849±4.30 6.937±0.00 0.882±0.00 13.506±0.00 1.557±1.15 21.608±0.00 9.659±3.41 10.307±0.00
ENST00000533668 N/A N/A N/A N/A N/A N/A N/A 0.920±0.00 N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008NR CIL_0008NR_0001 VISTA 8:38140056-38746180
CIL_0008SM CIL_0008SM_0001 VISTA 8:38252496-38854674
CIL_0008H7 CIL_0008H7_0001 VISTA 8:38253282-38854976
CIL_0008D9 CIL_0008D9_0001 VISTA 8:38350004-38951124

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0000165 TAS MAPK cascade
GO:0001501 TAS skeletal system development
GO:0001525 IEA angiogenesis
GO:0001657 IEA ureteric bud development
GO:0001701 IEA in utero embryonic development
GO:0001759 IEA organ induction
GO:0001764 TAS neuron migration
GO:0002053 IEA positive regulation of mesenchymal cell proliferation
GO:0002062 IEA chondrocyte differentiation
GO:0004672 IEA protein kinase activity
GO:0004713 IDA:IEA protein tyrosine kinase activity
GO:0005007 IEA:IDA fibroblast growth factor-activated receptor activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005576 NAS extracellular region
GO:0005634 IEA nucleus
GO:0005886 IDA plasma membrane
GO:0005887 TAS integral component of plasma membrane
GO:0006351 IEA transcription, DNA-templated
GO:0006468 NAS:IEA protein phosphorylation
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007411 TAS axon guidance
GO:0007420 IEA brain development
GO:0007435 IEA salivary gland morphogenesis
GO:0007605 IEA sensory perception of sound
GO:0008201 IDA heparin binding
GO:0008284 IMP:IEA positive regulation of cell proliferation
GO:0008286 TAS insulin receptor signaling pathway
GO:0008543 IEA:IPI fibroblast growth factor receptor signaling pathway
GO:0010468 IEA regulation of gene expression
GO:0010518 TAS positive regulation of phospholipase activity
GO:0010629 IEA negative regulation of gene expression
GO:0010863 IDA positive regulation of phospholipase C activity
GO:0010976 IEA positive regulation of neuron projection development
GO:0014068 TAS positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016021 NAS:IEA integral component of membrane
GO:0016477 TAS cell migration
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0017134 IDA fibroblast growth factor binding
GO:0018108 IDA peptidyl-tyrosine phosphorylation
GO:0021769 IEA orbitofrontal cortex development
GO:0021847 IEA ventricular zone neuroblast division
GO:0030324 IEA lung development
GO:0030326 IEA embryonic limb morphogenesis
GO:0030901 IEA midbrain development
GO:0031410 IEA cytoplasmic vesicle
GO:0035607 IEA fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042127 IEA regulation of cell proliferation
GO:0042472 IEA inner ear morphogenesis
GO:0042473 IEA outer ear morphogenesis
GO:0042474 IEA middle ear morphogenesis
GO:0042802 IPI identical protein binding
GO:0042803 IPI protein homodimerization activity
GO:0043009 TAS chordate embryonic development
GO:0043235 IDA receptor complex
GO:0043406 IDA positive regulation of MAP kinase activity
GO:0043410 IMP positive regulation of MAPK cascade
GO:0045087 TAS innate immune response
GO:0045595 TAS regulation of cell differentiation
GO:0045666 IMP positive regulation of neuron differentiation
GO:0045787 IEA positive regulation of cell cycle
GO:0046777 IDA protein autophosphorylation
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0048339 IEA paraxial mesoderm development
GO:0048378 IEA regulation of lateral mesodermal cell fate specification
GO:0048469 IEA cell maturation
GO:0048514 IEA blood vessel morphogenesis
GO:0048699 IEA generation of neurons
GO:0048705 TAS skeletal system morphogenesis
GO:0048762 IEA mesenchymal cell differentiation
GO:0060045 IEA positive regulation of cardiac muscle cell proliferation
GO:0060117 IEA auditory receptor cell development
GO:0060445 IEA branching involved in salivary gland morphogenesis
GO:0060484 IEA lung-associated mesenchyme development
GO:0060665 IEA regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0090080 IEA positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:2001239 IEA regulation of extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000011027 fgfr1a fibroblast growth factor receptor 1a protein_coding Danio_rerio
ENSDARG00000011190 fgfr1b fibroblast growth factor receptor 1b protein_coding Danio_rerio
ENSDARG00000075027 fgfr1bl fibroblast growth factor receptor 1b, like protein_coding Danio_rerio
ENSMUSG00000031565 Fgfr1 fibroblast growth factor receptor 1 protein_coding Mus_musculus

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