C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: apolipoprotein A-I
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000032083 Apoa1 10090 + 9:46228580-46230466 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000034588 Apoa1-001 46228580-46230466 protein_coding
  ENSMUST00000132155 Apoa1-002 46228721-46229973 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000034588ENSMUST00000132155
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000034588 0.594±0.39 1.597±1.10 0.312±0.06 1.079±0.75 5.971±5.71 0.746±0.23 0.548±0.32 0.449±0.24 3427.708±1678.96 1.327±0.30 0.238±0.27 28.823±14.47 1552.398±1700.49 0.465±0.27
ENSMUST00000132155 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 9.831±7.88 198.944±198.55 0.066±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007RC CIL_0007RC_0002 VISTA 9:45818249-46421546
CIL_0008EK CIL_0008EK_0002 VISTA 9:46081147-46681838

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001540 IEA beta-amyloid binding
GO:0001932 IDA regulation of protein phosphorylation
GO:0001935 IMP endothelial cell proliferation
GO:0002740 IEA negative regulation of cytokine secretion involved in immune response
GO:0005319 IDA lipid transporter activity
GO:0005515 IPI protein binding
GO:0005543 IEA phospholipid binding
GO:0005548 IEA phospholipid transporter activity
GO:0005576 IDA extracellular region
GO:0005615 IDA extracellular space
GO:0005634 IEA nucleus
GO:0005829 TAS cytosol
GO:0006644 IMP phospholipid metabolic process
GO:0006656 IEA phosphatidylcholine biosynthetic process
GO:0006695 IMP cholesterol biosynthetic process
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0007229 IEA integrin-mediated signaling pathway
GO:0007584 IEA response to nutrient
GO:0008035 IDA high-density lipoprotein particle binding
GO:0008203 IMP cholesterol metabolic process
GO:0008211 IMP glucocorticoid metabolic process
GO:0008289 IDA lipid binding
GO:0009986 IEA cell surface
GO:0010804 IEA negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0010873 IEA positive regulation of cholesterol esterification
GO:0010903 IEA negative regulation of very-low-density lipoprotein particle remodeling
GO:0014012 IEA peripheral nervous system axon regeneration
GO:0015485 IEA cholesterol binding
GO:0015914 IEA phospholipid transport
GO:0017127 IDA cholesterol transporter activity
GO:0018158 ISS protein oxidation
GO:0018206 ISS peptidyl-methionine modification
GO:0019899 IEA enzyme binding
GO:0019915 IMP lipid storage
GO:0030139 IEA endocytic vesicle
GO:0030300 IDA regulation of intestinal cholesterol absorption
GO:0030301 ISO cholesterol transport
GO:0030325 IMP adrenal gland development
GO:0031100 IEA organ regeneration
GO:0031410 IEA cytoplasmic vesicle
GO:0031982 IEA vesicle
GO:0032489 IEA regulation of Cdc42 protein signal transduction
GO:0033344 IDA cholesterol efflux
GO:0033700 IEA phospholipid efflux
GO:0034115 IEA negative regulation of heterotypic cell-cell adhesion
GO:0034190 IEA apolipoprotein receptor binding
GO:0034191 IEA apolipoprotein A-I receptor binding
GO:0034361 IEA very-low-density lipoprotein particle
GO:0034364 IEA high-density lipoprotein particle
GO:0034365 IEA discoidal high-density lipoprotein particle
GO:0034366 IEA spherical high-density lipoprotein particle
GO:0034380 IEA high-density lipoprotein particle assembly
GO:0035025 IEA positive regulation of Rho protein signal transduction
GO:0042158 IGI lipoprotein biosynthetic process
GO:0042493 IEA response to drug
GO:0042632 IEA cholesterol homeostasis
GO:0042802 IPI identical protein binding
GO:0043534 IMP blood vessel endothelial cell migration
GO:0043627 IEA response to estrogen
GO:0043691 IEA reverse cholesterol transport
GO:0045499 IEA chemorepellent activity
GO:0050713 IEA negative regulation of interleukin-1 beta secretion
GO:0050728 IEA negative regulation of inflammatory response
GO:0050821 IEA protein stabilization
GO:0050919 IEA negative chemotaxis
GO:0051345 IEA positive regulation of hydrolase activity
GO:0051346 IGI negative regulation of hydrolase activity
GO:0051347 IMP positive regulation of transferase activity
GO:0051496 IEA positive regulation of stress fiber assembly
GO:0055091 IEA phospholipid homeostasis
GO:0055102 IEA lipase inhibitor activity
GO:0060192 IEA negative regulation of lipase activity
GO:0060228 IEA phosphatidylcholine-sterol O-acyltransferase activator activity
GO:0060354 IEA negative regulation of cell adhesion molecule production
GO:0060761 IEA negative regulation of response to cytokine stimulus
GO:0070062 IEA extracellular vesicular exosome
GO:0070328 IEA triglyceride homeostasis
GO:0070508 IEA cholesterol import
GO:0070653 IEA high-density lipoprotein particle receptor binding
GO:0071813 IDA lipoprotein particle binding
GO:0072562 IEA blood microparticle
GO:1900026 IEA positive regulation of substrate adhesion-dependent cell spreading

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000012076 apoa1a apolipoprotein A-Ia protein_coding Danio_rerio
ENSDARG00000086583 apoa1b apolipoprotein A-Ib protein_coding Danio_rerio
ENSG00000118137 APOA1 apolipoprotein A-I protein_coding Homo_sapiens

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