C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: phospholipid scramblase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000032369 Plscr1 10090 + 9:92249750-92272278 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000093801 Plscr1-001 92249750-92272278 protein_coding
  ENSMUST00000186364 Plscr1-002 92250342-92271975 protein_coding
  ENSMUST00000187952 Plscr1-003 92266295-92271977 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000093801ENSMUST00000186364ENSMUST00000187952
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000093801 4.739±2.26 6.441±1.32 0.770±0.31 0.583±0.40 3.687±1.78 62.297±7.36 2.855±0.47 14.148±3.67 4.662±0.93 18.469±8.76 0.065±0.05 6.302±3.11 5.068±5.40 0.223±0.11
ENSMUST00000186364 1.709±0.84 7.927±1.44 1.645±0.22 0.867±0.43 1.356±0.37 18.775±0.00 1.238±0.46 2.220±0.00 3.754±1.48 6.988±1.05 0.342±0.13 6.295±3.55 6.108±4.69 0.118±0.00
ENSMUST00000187952 N/A N/A 0.991±0.22 0.538±0.17 1.831±0.00 N/A N/A N/A 5.065±0.31 N/A 0.288±0.14 5.520±1.04 5.772±3.88 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00065H CIL_00065H_0009 CGP 9:92192936-92272278
CIL_00065H CIL_00065H_0006 CGP 9:92249750-92297752

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001077 ISS RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 IEA DNA binding
GO:0005154 ISS epidermal growth factor receptor binding
GO:0005509 ISS calcium ion binding
GO:0005634 IDA nucleus
GO:0005730 ISS nucleolus
GO:0005794 ISS Golgi apparatus
GO:0005829 IDA cytosol
GO:0005886 IDA plasma membrane
GO:0005887 ISS integral component of plasma membrane
GO:0006659 IDA phosphatidylserine biosynthetic process
GO:0006953 IEP acute-phase response
GO:0017121 IDA phospholipid scrambling
GO:0017124 ISS SH3 domain binding
GO:0017128 ISS phospholipid scramblase activity
GO:0030099 IMP myeloid cell differentiation
GO:0031012 ISS extracellular matrix
GO:0032091 IDA negative regulation of protein binding
GO:0033003 ISS regulation of mast cell activation
GO:0035455 IMP response to interferon-alpha
GO:0042609 ISS CD4 receptor binding
GO:0043065 IGI positive regulation of apoptotic process
GO:0045071 IMP negative regulation of viral genome replication
GO:0045089 IMP positive regulation of innate immune response
GO:0045121 ISS membrane raft
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0051607 IMP defense response to virus
GO:0060368 ISS regulation of Fc receptor mediated stimulatory signaling pathway
GO:0070782 IDA phosphatidylserine exposure on apoptotic cell surface
GO:0071222 IEP cellular response to lipopolysaccharide
GO:0071345 IEP cellular response to cytokine stimulus
GO:0097193 IDA intrinsic apoptotic signaling pathway
GO:1902231 IDA positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:2000373 ISS positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000045470 FP245465.1 Uncharacterized protein protein_coding Danio_rerio
ENSDARG00000058638 si:ch211-71m22.1 si:ch211-71m22.1 protein_coding Danio_rerio
ENSDARG00000077468 si:ch73-206p6.1 si:ch73-206p6.1 protein_coding Danio_rerio
ENSDARG00000079075 si:ch211-71m22.3 si:ch211-71m22.3 protein_coding Danio_rerio
ENSDARG00000091266 si:ch211-71m22.5 si:ch211-71m22.5 protein_coding Danio_rerio
ENSG00000163746 PLSCR2 phospholipid scramblase 2 protein_coding Homo_sapiens
ENSG00000188313 PLSCR1 phospholipid scramblase 1 protein_coding Homo_sapiens

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