C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: phospholipid scramblase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000188313 PLSCR1 9606 - 3:146515180-146544864 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000342435 PLSCR1-001 146515180-146544864 protein_coding
  ENST00000448787 PLSCR1-003 146515955-146544620 protein_coding
  ENST00000462666 PLSCR1-014 146517089-146544570 protein_coding
  ENST00000463777 PLSCR1-012 146515802-146544555 nonsense_mediated_decay
  ENST00000468985 PLSCR1-008 146515952-146544555 nonsense_mediated_decay
  ENST00000469266 PLSCR1-004 146527943-146544727 retained_intron
  ENST00000470496 PLSCR1-020 146517012-146521712 processed_transcript
  ENST00000472349 PLSCR1-007 146517158-146544856 protein_coding
  ENST00000477974 PLSCR1-006 146540853-146544553 processed_transcript
  ENST00000478267 PLSCR1-015 146516903-146544538 nonsense_mediated_decay
  ENST00000483300 PLSCR1-018 146516088-146528750 protein_coding
  ENST00000484560 PLSCR1-019 146516440-146517394 processed_transcript
  ENST00000486631 PLSCR1-011 146517149-146544641 protein_coding
  ENST00000487389 PLSCR1-002 146515817-146544737 protein_coding
  ENST00000488253 PLSCR1-016 146516059-146544530 nonsense_mediated_decay
  ENST00000489775 PLSCR1-009 146516070-146544547 nonsense_mediated_decay
  ENST00000490745 PLSCR1-010 146525529-146536819 retained_intron
  ENST00000493432 PLSCR1-005 146515181-146544521 nonsense_mediated_decay
  ENST00000494568 PLSCR1-013 146521717-146544578 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000342435ENST00000448787ENST00000462666ENST00000463777ENST00000469266ENST00000478267ENST00000487389ENST00000494568
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000342435 6.033±0.00 12.659±0.00 1.238±0.00 1.087±0.00 5.093±0.00 6.267±1.89 2.334±0.00 13.742±0.00 2.167±0.26 8.367±2.84 0.548±0.00 5.930±4.17 4.010±0.00 2.613±0.00
ENST00000448787 13.492±0.00 25.430±0.00 N/A 5.137±0.00 7.117±0.40 8.995±2.00 6.129±0.00 16.849±0.00 8.910±0.00 29.555±0.00 2.123±0.30 13.009±4.87 11.789±4.62 6.243±3.86
ENST00000462666 12.945±0.00 N/A N/A N/A 6.521±0.49 9.404±0.00 N/A 5.978±0.00 3.067±0.00 21.932±0.00 N/A 8.954±0.00 9.480±3.02 10.292±0.00
ENST00000463777 N/A N/A N/A 4.742±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 8.162±0.00 2.805±0.00
ENST00000469266 N/A N/A N/A N/A 4.798±0.00 N/A 0.973±0.00 2.511±0.00 N/A N/A N/A N/A N/A N/A
ENST00000478267 N/A N/A 3.065±0.00 1.645±0.00 N/A N/A 1.108±0.00 N/A 4.937±0.00 7.648±0.00 N/A N/A N/A N/A
ENST00000487389 7.916±0.00 11.076±0.00 N/A N/A 4.795±0.00 10.237±0.00 2.889±0.00 7.538±0.00 4.071±0.00 12.222±0.00 1.048±0.00 10.360±0.37 9.061±0.96 4.912±2.11
ENST00000494568 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 9.283±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00065H CIL_00065H_0004 CGP 3:146391421-146544864
CIL_00065H CIL_00065H_0005 CGP 3:146515180-146606216

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001077 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 IEA DNA binding
GO:0005154 IPI epidermal growth factor receptor binding
GO:0005509 IDA calcium ion binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005730 IDA nucleolus
GO:0005794 IDA Golgi apparatus
GO:0005829 IDA cytosol
GO:0005886 IDA plasma membrane
GO:0005887 IDA integral component of plasma membrane
GO:0006659 ISS phosphatidylserine biosynthetic process
GO:0006915 IDA apoptotic process
GO:0006953 ISS acute-phase response
GO:0010628 IMP positive regulation of gene expression
GO:0016020 IDA membrane
GO:0017121 IDA phospholipid scrambling
GO:0017124 IDA SH3 domain binding
GO:0017128 IDA phospholipid scramblase activity
GO:0019899 IPI enzyme binding
GO:0030168 NAS platelet activation
GO:0031012 IDA extracellular matrix
GO:0033003 ISS regulation of mast cell activation
GO:0035456 IMP response to interferon-beta
GO:0042609 IPI CD4 receptor binding
GO:0045071 IMP negative regulation of viral genome replication
GO:0045089 IMP positive regulation of innate immune response
GO:0045121 IDA membrane raft
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0051607 IMP defense response to virus
GO:0060368 ISS regulation of Fc receptor mediated stimulatory signaling pathway
GO:0070062 IDA extracellular vesicular exosome
GO:2000373 IDA positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000045470 FP245465.1 Uncharacterized protein protein_coding Danio_rerio
ENSDARG00000058638 si:ch211-71m22.1 si:ch211-71m22.1 protein_coding Danio_rerio
ENSDARG00000077468 si:ch73-206p6.1 si:ch73-206p6.1 protein_coding Danio_rerio
ENSDARG00000079075 si:ch211-71m22.3 si:ch211-71m22.3 protein_coding Danio_rerio
ENSDARG00000091266 si:ch211-71m22.5 si:ch211-71m22.5 protein_coding Danio_rerio
ENSMUSG00000032369 Plscr1 phospholipid scramblase 1 protein_coding Mus_musculus
ENSMUSG00000032372 Plscr2 phospholipid scramblase 2 protein_coding Mus_musculus
ENSMUSG00000074139 1700057G04Rik RIKEN cDNA 1700057G04 gene protein_coding Mus_musculus

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