C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: SMAD family member 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000032402 Smad3 10090 - 9:63646767-63757994 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000034973 Smad3-001 63646767-63757994 protein_coding
  ENSMUST00000133108 Smad3-004 63666148-63751077 protein_coding
  ENSMUST00000137065 Smad3-003 63667813-63743265 processed_transcript
  ENSMUST00000137713 Smad3-005 63654771-63666547 protein_coding
  ENSMUST00000154323 Smad3-002 63654799-63711969 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000034973ENSMUST00000154323
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000034973 9.600±4.10 8.811±1.69 13.736±2.27 7.078±1.49 8.209±3.41 13.342±0.77 2.467±0.78 8.775±1.59 2.714±0.54 11.864±0.90 2.564±0.52 19.689±8.08 4.385±2.44 1.186±0.46
ENSMUST00000154323 N/A N/A N/A N/A N/A N/A N/A N/A 2.062±0.00 N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007L5 CIL_0007L5_0002 UCNEbase 9:63176391-63881226
CIL_0008V3 CIL_0008V3_0002 VISTA 9:63223990-63824533
CIL_0008R9 CIL_0008R9_0002 VISTA 9:63580198-64181507

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000790 IEA nuclear chromatin
GO:0000987 ISS core promoter proximal region sequence-specific DNA binding
GO:0000988 IEA protein binding transcription factor activity
GO:0001102 IEA RNA polymerase II activating transcription factor binding
GO:0001501 IGI skeletal system development
GO:0001649 IMP osteoblast differentiation
GO:0001657 IEP ureteric bud development
GO:0001666 IEA response to hypoxia
GO:0001701 IGI in utero embryonic development
GO:0001707 IMP mesoderm formation
GO:0001756 IMP somitogenesis
GO:0001889 IGI liver development
GO:0001933 IEA negative regulation of protein phosphorylation
GO:0001947 IGI heart looping
GO:0002076 IGI osteoblast development
GO:0002520 IGI immune system development
GO:0003677 IEA DNA binding
GO:0003682 IDA chromatin binding
GO:0003690 IDA double-stranded DNA binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005160 IEA transforming growth factor beta receptor binding
GO:0005515 IPI protein binding
GO:0005518 IPI collagen binding
GO:0005634 IDA nucleus
GO:0005637 IEA nuclear inner membrane
GO:0005667 ISS transcription factor complex
GO:0005737 IDA cytoplasm
GO:0005886 IDA plasma membrane
GO:0006351 IEA transcription, DNA-templated
GO:0006366 TAS transcription from RNA polymerase II promoter
GO:0006810 IEA transport
GO:0006919 IEA activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006955 IEA immune response
GO:0007050 IEA cell cycle arrest
GO:0007179 IDA transforming growth factor beta receptor signaling pathway
GO:0007183 IEA SMAD protein complex assembly
GO:0007369 IGI gastrulation
GO:0007492 IGI endoderm development
GO:0008013 IEA beta-catenin binding
GO:0008134 IPI transcription factor binding
GO:0008270 IEA zinc ion binding
GO:0008285 IEA negative regulation of cell proliferation
GO:0009880 IGI embryonic pattern specification
GO:0010628 IEA positive regulation of gene expression
GO:0010694 IEA positive regulation of alkaline phosphatase activity
GO:0010718 IEA positive regulation of epithelial to mesenchymal transition
GO:0016202 IDA regulation of striated muscle tissue development
GO:0017015 IDA regulation of transforming growth factor beta receptor signaling pathway
GO:0019049 IEA evasion or tolerance of host defenses by virus
GO:0019899 IEA enzyme binding
GO:0019901 IEA protein kinase binding
GO:0019902 IEA phosphatase binding
GO:0023019 IEA signal transduction involved in regulation of gene expression
GO:0030308 IEA negative regulation of cell growth
GO:0030335 IEA positive regulation of cell migration
GO:0030501 IEA positive regulation of bone mineralization
GO:0030618 IEA transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
GO:0030878 IGI thyroid gland development
GO:0031490 IDA chromatin DNA binding
GO:0031625 IEA ubiquitin protein ligase binding
GO:0032332 IMP positive regulation of chondrocyte differentiation
GO:0032731 IEA positive regulation of interleukin-1 beta production
GO:0032909 IEA regulation of transforming growth factor beta2 production
GO:0032916 IEA positive regulation of transforming growth factor beta3 production
GO:0032924 IEA activin receptor signaling pathway
GO:0033689 IMP negative regulation of osteoblast proliferation
GO:0035413 IEA positive regulation of catenin import into nucleus
GO:0035556 IEA intracellular signal transduction
GO:0038092 IEA nodal signaling pathway
GO:0042110 IMP T cell activation
GO:0042177 IEA negative regulation of protein catabolic process
GO:0042803 IEA protein homodimerization activity
GO:0042993 IEA positive regulation of transcription factor import into nucleus
GO:0043066 IEA negative regulation of apoptotic process
GO:0043130 IEA ubiquitin binding
GO:0043234 IEA protein complex
GO:0043235 IEA receptor complex
GO:0043425 IEA bHLH transcription factor binding
GO:0043565 IEA sequence-specific DNA binding
GO:0044212 IEA transcription regulatory region DNA binding
GO:0045216 IEA cell-cell junction organization
GO:0045668 IGI negative regulation of osteoblast differentiation
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045930 IEA negative regulation of mitotic cell cycle
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046332 IEA SMAD binding
GO:0048340 IMP paraxial mesoderm morphogenesis
GO:0048589 IGI developmental growth
GO:0048617 IGI embryonic foregut morphogenesis
GO:0048701 IGI embryonic cranial skeleton morphogenesis
GO:0050678 IMP regulation of epithelial cell proliferation
GO:0050728 IMP negative regulation of inflammatory response
GO:0050776 IMP regulation of immune response
GO:0050821 IEA protein stabilization
GO:0050927 IEA positive regulation of positive chemotaxis
GO:0051098 IDA regulation of binding
GO:0051496 IEA positive regulation of stress fiber assembly
GO:0051894 IEA positive regulation of focal adhesion assembly
GO:0060039 IGI pericardium development
GO:0060290 IEA transdifferentiation
GO:0060395 IGI SMAD protein signal transduction
GO:0061045 IMP negative regulation of wound healing
GO:0070306 IMP lens fiber cell differentiation
GO:0070410 IEA co-SMAD binding
GO:0070412 IEA R-SMAD binding
GO:0071141 ISS SMAD protein complex
GO:0071144 IEA SMAD2-SMAD3 protein complex
GO:0090263 IEA positive regulation of canonical Wnt signaling pathway
GO:0097191 IEA extrinsic apoptotic signaling pathway
GO:0097296 IEA activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:1901313 IEA positive regulation of gene expression involved in extracellular matrix organization

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000010207 smad3b MAD, mothers against decapentaplegic homolog 3b (Drosophila) protein_coding Danio_rerio
ENSDARG00000036096 smad3a MAD homolog 3a (Drosophila) protein_coding Danio_rerio
ENSG00000166949 SMAD3 SMAD family member 3 protein_coding Homo_sapiens

Loading