C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mitogen-activated protein kinase kinase 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000033352 Map2k4 10090 - 11:65688243-65788297 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000046963 Map2k4-005 65688243-65788297 protein_coding
  ENSMUST00000125598 Map2k4-007 65690333-65719603 protein_coding
  ENSMUST00000130009 Map2k4-002 65712220-65788285 nonsense_mediated_decay
  ENSMUST00000138093 Map2k4-004 65719539-65745838 processed_transcript
  ENSMUST00000140301 Map2k4-001 65696288-65788285 nonsense_mediated_decay
  ENSMUST00000140740 Map2k4-006 65691728-65697014 processed_transcript
  ENSMUST00000152096 Map2k4-003 65712219-65788286 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000046963ENSMUST00000125598ENSMUST00000130009ENSMUST00000140301ENSMUST00000152096
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000046963 5.162±1.07 6.364±3.08 14.265±2.92 17.785±5.68 3.818±2.35 2.768±0.55 4.403±0.28 4.474±0.59 8.233±4.33 6.777±1.89 15.505±1.93 9.245±4.61 15.491±5.48 1.089±0.26
ENSMUST00000125598 N/A N/A N/A 43.468±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 14.887±2.10 N/A
ENSMUST00000130009 N/A N/A N/A N/A N/A 7.661±0.03 N/A N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000140301 N/A 12.996±1.43 N/A N/A N/A N/A N/A N/A N/A N/A N/A 12.456±0.00 18.577±0.00 N/A
ENSMUST00000152096 N/A N/A N/A 113.141±0.00 N/A N/A N/A N/A N/A N/A N/A 28.807±14.70 73.957±4.68 10.890±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007YN CIL_0007YN_0002 VISTA 11:65135465-65736246
CIL_0008WK CIL_0008WK_0002 VISTA 11:65348906-65951643

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000165 IPI MAPK cascade
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0004672 IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004708 IEA MAP kinase kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005829 TAS cytosol
GO:0006468 IEA protein phosphorylation
GO:0006915 IEA apoptotic process
GO:0007254 ISO JNK cascade
GO:0007257 ISO activation of JUN kinase activity
GO:0008545 IEA JUN kinase kinase activity
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0030424 IEA axon
GO:0031435 IEA mitogen-activated protein kinase kinase kinase binding
GO:0032839 IEA dendrite cytoplasm
GO:0043065 IEA positive regulation of apoptotic process
GO:0043204 IEA perikaryon
GO:0043525 IEA positive regulation of neuron apoptotic process
GO:0045740 IEA positive regulation of DNA replication
GO:0051770 IEA positive regulation of nitric-oxide synthase biosynthetic process
GO:0061049 IEA cell growth involved in cardiac muscle cell development
GO:0071260 IEA cellular response to mechanical stimulus
GO:0072709 IEA cellular response to sorbitol

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000063583 map2k4a mitogen-activated protein kinase kinase 4a protein_coding Danio_rerio
ENSDARG00000077177 map2k4b mitogen-activated protein kinase kinase 4b protein_coding Danio_rerio
ENSG00000065559 MAP2K4 mitogen-activated protein kinase kinase 4 protein_coding Homo_sapiens

Loading