C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mitogen-activated protein kinase kinase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000035027 Map2k2 10090 + 10:81105915-81124697 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000048223 Map2k2-003 81105972-81123845 nonsense_mediated_decay
  ENSMUST00000105331 Map2k2-002 81105947-81123883 protein_coding
  ENSMUST00000123241 Map2k2-006 81122160-81123927 retained_intron
  ENSMUST00000123888 Map2k2-005 81118612-81119327 retained_intron
  ENSMUST00000128937 Map2k2-004 81120854-81122562 retained_intron
  ENSMUST00000136743 Map2k2-007 81106345-81119125 protein_coding
  ENSMUST00000143517 Map2k2-001 81105915-81124697 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000105331ENSMUST00000123241ENSMUST00000136743ENSMUST00000143517
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000105331 49.166±4.37 271.933±75.73 43.224±0.09 58.565±1.58 56.106±26.13 105.849±7.25 36.263±10.88 64.082±2.47 58.047±21.33 57.043±9.96 71.396±10.94 76.682±26.27 54.256±18.12 64.394±11.95
ENSMUST00000123241 N/A N/A N/A N/A 5.163±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000136743 N/A N/A N/A 35.154±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 31.245±0.00 N/A
ENSMUST00000143517 6.880±1.03 N/A 7.830±0.52 16.176±0.86 7.600±0.74 12.865±1.16 3.372±0.76 9.312±0.91 7.168±1.64 7.264±0.64 10.227±1.27 10.590±1.37 8.724±1.83 7.831±1.30

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000165 IEA MAPK cascade
GO:0000187 TAS activation of MAPK activity
GO:0004672 IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004708 IEA MAP kinase kinase activity
GO:0004712 TAS protein serine/threonine/tyrosine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 TAS nucleus
GO:0005737 IDA cytoplasm
GO:0005739 TAS mitochondrion
GO:0005769 TAS early endosome
GO:0005770 TAS late endosome
GO:0005778 IEA peroxisomal membrane
GO:0005783 IEA endoplasmic reticulum
GO:0005794 TAS Golgi apparatus
GO:0005829 TAS cytosol
GO:0005874 IEA microtubule
GO:0005911 IEA cell-cell junction
GO:0005925 TAS focal adhesion
GO:0005938 IEA cell cortex
GO:0006468 IEA protein phosphorylation
GO:0009898 IEA cytoplasmic side of plasma membrane
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0030165 IEA PDZ domain binding
GO:0032872 TAS regulation of stress-activated MAPK cascade
GO:0032947 IDA protein complex scaffold
GO:0036289 IEA peptidyl-serine autophosphorylation
GO:0043539 IEA protein serine/threonine kinase activator activity
GO:0048471 IEA perinuclear region of cytoplasm
GO:0071902 IEA positive regulation of protein serine/threonine kinase activity
GO:0090170 TAS regulation of Golgi inheritance
GO:0097110 IEA scaffold protein binding
GO:2000147 IDA positive regulation of cell motility
GO:2000641 TAS regulation of early endosome to late endosome transport

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000006609 map2k2a mitogen-activated protein kinase kinase 2a protein_coding Danio_rerio
ENSDARG00000068918 map2k2b mitogen-activated protein kinase kinase 2b protein_coding Danio_rerio
ENSG00000126934 MAP2K2 mitogen-activated protein kinase kinase 2 protein_coding Homo_sapiens

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