C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: transglutaminase 2, C polypeptide
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000037820 Tgm2 10090 - 2:158116402-158146436 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000103122 Tgm2-001 158116402-158146436 protein_coding
  ENSMUST00000140923 Tgm2-003 158130380-158146366 retained_intron
  ENSMUST00000152690 Tgm2-002 158134322-158139736 processed_transcript
  ENSMUST00000174718 Tgm2-004 158127345-158146393 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000103122ENSMUST00000174718
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000103122 121.524±38.54 29.302±7.83 92.525±2.32 4.010±0.47 126.614±23.53 47.484±3.84 60.873±5.82 86.734±10.89 41.088±6.63 130.682±11.88 22.630±4.04 105.980±41.72 137.114±78.00 3.397±1.28
ENSMUST00000174718 N/A N/A N/A N/A 138.997±1.10 N/A N/A N/A N/A 123.591±0.00 N/A 126.888±5.31 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004NX CIL_0004NX_0002 CGP 2:157981803-158132297
CIL_0004NY CIL_0004NY_0002 CGP 2:158028497-158146436
CIL_0004NZ CIL_0004NZ_0002 CGP 2:158116402-158229222

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001974 IEA blood vessel remodeling
GO:0003810 IMP protein-glutamine gamma-glutamyltransferase activity
GO:0005509 NAS calcium ion binding
GO:0005515 IEA protein binding
GO:0005525 NAS GTP binding
GO:0005578 TAS proteinaceous extracellular matrix
GO:0005737 ISA cytoplasm
GO:0005739 IEA mitochondrion
GO:0005829 TAS cytosol
GO:0005886 IEA plasma membrane
GO:0005925 IEA focal adhesion
GO:0007186 TAS G-protein coupled receptor signaling pathway
GO:0007200 ISA phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0008483 ISO transaminase activity
GO:0016020 TAS membrane
GO:0018149 TAS peptide cross-linking
GO:0018153 IEA isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine
GO:0019904 IEA protein domain specific binding
GO:0032471 IMP negative regulation of endoplasmic reticulum calcium ion concentration
GO:0043065 IEA positive regulation of apoptotic process
GO:0043123 IEA positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043277 IEA apoptotic cell clearance
GO:0045785 IMP positive regulation of cell adhesion
GO:0048661 IEA positive regulation of smooth muscle cell proliferation
GO:0050729 IEA positive regulation of inflammatory response
GO:0051260 IEA protein homooligomerization
GO:0051482 IEA positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0051561 IMP positive regulation of mitochondrial calcium ion concentration
GO:0060445 IMP branching involved in salivary gland morphogenesis
GO:0060662 IMP salivary gland cavitation
GO:0070062 IEA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000070157 tgm2a transglutaminase 2, C polypeptide A protein_coding Danio_rerio
ENSDARG00000074094 tgm2b transglutaminase 2b protein_coding Danio_rerio
ENSG00000198959 TGM2 transglutaminase 2 protein_coding Homo_sapiens

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