C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: early growth response 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000038418 Egr1 10090 + 18:34859823-34864984 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000064795 Egr1-001 34859823-34864984 protein_coding
  ENSMUST00000165033 Egr1-201 34861207-34864956 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000064795ENSMUST00000165033
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000064795 0.721±0.00 6.677±0.99 0.815±0.35 0.212±0.09 5.179±2.24 2.072±0.44 N/A 0.224±0.03 0.579±0.26 1.642±0.65 0.112±0.00 13.269±2.43 0.390±0.30 0.453±0.13
ENSMUST00000165033 7.333±0.94 5.372±0.86 6.667±2.29 6.173±7.15 17.245±7.91 6.925±2.39 5.407±0.53 1.896±0.24 2.396±1.23 7.883±3.02 1.021±0.17 23.761±15.33 0.925±0.44 1.954±1.26

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005DD CIL_0005DD_0002 CGP 18:34840589-34864984
CIL_0005DC CIL_0005DC_0002 CGP 18:34859823-34932007

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000976 IEA transcription regulatory region sequence-specific DNA binding
GO:0000977 IMP RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000979 IEA RNA polymerase II core promoter sequence-specific DNA binding
GO:0000982 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
GO:0001077 IMP RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001975 IEA response to amphetamine
GO:0003677 IEA DNA binding
GO:0003690 IEA double-stranded DNA binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005515 IEA protein binding
GO:0005634 ISS nucleus
GO:0005737 ISS cytoplasm
GO:0006355 IMP regulation of transcription, DNA-templated
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0007611 IEA learning or memory
GO:0007623 IEA circadian rhythm
GO:0008134 IEA transcription factor binding
GO:0009749 IDA response to glucose
GO:0010628 IEA positive regulation of gene expression
GO:0010942 IEA positive regulation of cell death
GO:0030217 IMP T cell differentiation
GO:0030509 IDA BMP signaling pathway
GO:0031667 IEA response to nutrient levels
GO:0032354 IEA response to follicle-stimulating hormone
GO:0032868 IDA response to insulin
GO:0032869 IEA cellular response to insulin stimulus
GO:0033233 IEA regulation of protein sumoylation
GO:0034465 IEA response to carbon monoxide
GO:0034698 IEA response to gonadotropin
GO:0035035 IEA histone acetyltransferase binding
GO:0035690 IEA cellular response to drug
GO:0035914 IMP skeletal muscle cell differentiation
GO:0042220 IEA response to cocaine
GO:0042493 IEA response to drug
GO:0043066 IBA negative regulation of apoptotic process
GO:0043525 IEA positive regulation of neuron apoptotic process
GO:0043565 IEA sequence-specific DNA binding
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045471 IEA response to ethanol
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046872 IEA metal ion binding
GO:0048169 IBA regulation of long-term neuronal synaptic plasticity
GO:0048709 IEA oligodendrocyte differentiation
GO:0051602 IEA response to electrical stimulus
GO:0060291 IEA long-term synaptic potentiation
GO:0070498 IEA interleukin-1-mediated signaling pathway
GO:0071236 IEA cellular response to antibiotic
GO:0071260 IEA cellular response to mechanical stimulus
GO:0071310 IDA cellular response to organic substance
GO:0071317 IEA cellular response to isoquinoline alkaloid
GO:0071320 IBA cellular response to cAMP
GO:0071363 IEA cellular response to growth factor stimulus
GO:0071371 IBA cellular response to gonadotropin stimulus
GO:0071372 IEA cellular response to follicle-stimulating hormone stimulus
GO:0071383 IEA cellular response to steroid hormone stimulus
GO:0071455 IEA cellular response to hyperoxia
GO:0071456 IEA cellular response to hypoxia
GO:0071480 IMP cellular response to gamma radiation
GO:0071504 ISS cellular response to heparin
GO:0071506 ISS cellular response to mycophenolic acid
GO:0071873 IEA response to norepinephrine
GO:0072110 ISS glomerular mesangial cell proliferation
GO:0072303 ISS positive regulation of glomerular metanephric mesangial cell proliferation
GO:0090090 IMP negative regulation of canonical Wnt signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000037421 egr1 early growth response 1 protein_coding Danio_rerio
ENSG00000120738 EGR1 early growth response 1 protein_coding Homo_sapiens

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