C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: protein phosphatase 2A activator, regulatory subunit B
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000039515 Ppp2r4 10090 + 2:30416039-30447806 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000042055 Ppp2r4-001 30416039-30447805 protein_coding
  ENSMUST00000113601 Ppp2r4-003 30416131-30447806 protein_coding
  ENSMUST00000113603 Ppp2r4-002 30416142-30447617 protein_coding
  ENSMUST00000125561 Ppp2r4-009 30438229-30446950 nonsense_mediated_decay
  ENSMUST00000125743 Ppp2r4-004 30416196-30447804 retained_intron
  ENSMUST00000128516 Ppp2r4-005 30428354-30438101 retained_intron
  ENSMUST00000130741 Ppp2r4-010 30445656-30447074 processed_transcript
  ENSMUST00000131476 Ppp2r4-006 30441853-30447131 protein_coding
  ENSMUST00000135105 Ppp2r4-011 30445716-30446776 processed_transcript
  ENSMUST00000136009 Ppp2r4-007 30442735-30446806 protein_coding
  ENSMUST00000137741 Ppp2r4-008 30443219-30446899 processed_transcript
  ENSMUST00000152165 Ppp2r4-013 30416137-30432029 nonsense_mediated_decay
  ENSMUST00000159932 Ppp2r4-014 30416302-30428402 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000042055ENSMUST00000113601ENSMUST00000113603ENSMUST00000125743ENSMUST00000131476ENSMUST00000137741
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000042055 76.534±22.07 57.633±8.62 34.606±2.53 34.636±5.69 50.448±10.05 29.043±2.26 22.418±2.82 42.515±4.60 37.412±26.40 37.372±0.94 13.256±1.48 33.940±8.13 21.396±10.51 16.806±12.28
ENSMUST00000113601 N/A N/A N/A N/A N/A N/A N/A 16.538±5.18 N/A N/A N/A N/A N/A N/A
ENSMUST00000113603 N/A N/A N/A 8.992±0.00 N/A 8.923±0.65 N/A N/A N/A N/A N/A 12.313±2.71 5.552±2.61 2.101±0.00
ENSMUST00000125743 9.824±0.36 8.915±0.00 5.400±0.00 9.219±1.47 11.864±2.15 7.866±1.24 2.889±0.00 6.701±0.63 5.161±2.93 7.367±0.91 N/A 11.258±4.40 2.703±0.01 2.633±1.87
ENSMUST00000131476 N/A 32.422±2.79 N/A N/A N/A N/A 17.387±0.05 N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000137741 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 24.888±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003C7 CIL_0003C7_0002 CGP 2:30400471-30447806
CIL_0003CA CIL_0003CA_0002 CGP 2:30416039-30474219

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000159 IBA protein phosphatase type 2A complex
GO:0000413 IBA:IEA protein peptidyl-prolyl isomerization
GO:0003755 IBA peptidyl-prolyl cis-trans isomerase activity
GO:0005102 IEA receptor binding
GO:0005524 ISS ATP binding
GO:0005634 IBA nucleus
GO:0005737 IBA cytoplasm
GO:0006200 IEA ATP catabolic process
GO:0006457 IEA protein folding
GO:0008160 IBA:ISS protein tyrosine phosphatase activator activity
GO:0008601 IBA:ISS protein phosphatase type 2A regulator activity
GO:0016887 ISS ATPase activity
GO:0030472 IBA mitotic spindle organization in nucleus
GO:0032515 ISS negative regulation of phosphoprotein phosphatase activity
GO:0032516 ISS positive regulation of phosphoprotein phosphatase activity
GO:0034704 IEA calcium channel complex
GO:0035307 ISS positive regulation of protein dephosphorylation
GO:0035308 ISS negative regulation of protein dephosphorylation
GO:0042803 ISS protein homodimerization activity
GO:0043065 IEA positive regulation of apoptotic process
GO:0043085 IEA positive regulation of catalytic activity
GO:0043666 ISS regulation of phosphoprotein phosphatase activity
GO:0050790 IBA regulation of catalytic activity
GO:0051721 ISS protein phosphatase 2A binding
GO:0070062 IEA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000031985 ppp2r4 protein phosphatase 2A activator, regulatory subunit 4 protein_coding Danio_rerio
ENSG00000119383 PPP2R4 protein phosphatase 2A activator, regulatory subunit 4 protein_coding Homo_sapiens

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