C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: large tumor suppressor
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000040021 Lats1 10090 + 10:7681209-7716458 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000040043 Lats1-201 7691247-7713586 protein_coding
  ENSMUST00000165952 Lats1-202 7681209-7716458 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000040043ENSMUST00000165952
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000040043 N/A N/A N/A 0.835±0.00 N/A N/A N/A N/A N/A N/A 0.495±0.00 3.019±0.63 1.327±0.43 3.316±0.55
ENSMUST00000165952 10.486±2.72 12.009±0.89 8.658±0.51 11.423±7.74 11.079±0.82 10.743±0.99 2.744±0.90 9.332±1.44 5.623±0.72 10.734±0.72 1.738±0.32 14.442±3.28 3.353±2.57 3.523±1.65

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000086 ISS G2/M transition of mitotic cell cycle
GO:0000287 ISS magnesium ion binding
GO:0000819 ISS sister chromatid segregation
GO:0000922 ISS spindle pole
GO:0004674 ISS protein serine/threonine kinase activity
GO:0005524 ISS ATP binding
GO:0005737 IEA cytoplasm
GO:0006468 ISS protein phosphorylation
GO:0007067 IEA mitotic nuclear division
GO:0009755 IDA hormone-mediated signaling pathway
GO:0019901 IEA protein kinase binding
GO:0030216 IGI keratinocyte differentiation
GO:0030833 ISS regulation of actin filament polymerization
GO:0033138 IEA positive regulation of peptidyl-serine phosphorylation
GO:0034613 IGI cellular protein localization
GO:0035329 IGI hippo signaling
GO:0043254 IEA regulation of protein complex assembly
GO:0045736 ISS negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0051220 IEA cytoplasmic sequestering of protein
GO:0090090 IEA negative regulation of canonical Wnt signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000003751 lats1 LATS, large tumor suppressor, homolog 1 (Drosophila) protein_coding Danio_rerio
ENSG00000131023 LATS1 large tumor suppressor kinase 1 protein_coding Homo_sapiens

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