C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cardiotrophin-like cytokine factor 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000040663 Clcf1 10090 + 19:4214238-4223490 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000046506 Clcf1-001 4214238-4223490 protein_coding
  ENSMUST00000126457 Clcf1-004 4214594-4222513 processed_transcript
  ENSMUST00000132305 Clcf1-003 4214264-4223490 retained_intron
  ENSMUST00000138090 Clcf1-002 4214305-4223490 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000046506ENSMUST00000126457ENSMUST00000132305ENSMUST00000138090
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000046506 2.256±1.21 0.958±0.16 1.721±0.00 N/A 10.895±0.59 0.639±0.08 N/A 0.851±0.00 0.426±0.04 N/A 0.140±0.06 2.689±0.00 0.282±0.12 N/A
ENSMUST00000126457 N/A 3.069±0.97 N/A N/A 17.742±3.47 3.391±1.38 N/A 3.957±0.00 0.286±0.12 11.540±0.00 N/A 9.548±2.02 0.950±0.56 N/A
ENSMUST00000132305 3.209±2.39 2.430±0.78 3.498±0.38 0.428±0.31 7.802±3.53 1.315±0.39 0.864±0.35 1.637±0.65 0.343±0.23 5.015±1.18 0.274±0.13 3.889±2.04 0.275±0.21 0.367±0.13
ENSMUST00000138090 N/A N/A N/A 0.089±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002639 IDA positive regulation of immunoglobulin production
GO:0002830 NAS positive regulation of type 2 immune response
GO:0005102 ISS receptor binding
GO:0005125 IDA cytokine activity
GO:0005127 ISS ciliary neurotrophic factor receptor binding
GO:0005515 IPI protein binding
GO:0005576 ISS extracellular region
GO:0005622 TAS intracellular
GO:0007166 IDA cell surface receptor signaling pathway
GO:0007259 IDA JAK-STAT cascade
GO:0008284 ISS positive regulation of cell proliferation
GO:0030183 IDA B cell differentiation
GO:0030890 IDA positive regulation of B cell proliferation
GO:0042517 IDA positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043524 ISS negative regulation of neuron apoptotic process
GO:0046982 ISS protein heterodimerization activity
GO:0048295 IDA positive regulation of isotype switching to IgE isotypes
GO:0048711 IDA positive regulation of astrocyte differentiation
GO:0050727 NAS regulation of inflammatory response
GO:0051466 TAS positive regulation of corticotropin-releasing hormone secretion
GO:0051896 TAS regulation of protein kinase B signaling
GO:0070062 IEA extracellular vesicular exosome
GO:0070372 TAS regulation of ERK1 and ERK2 cascade
GO:0097058 IEA CRLF-CLCF1 complex
GO:0097059 IEA CNTFR-CLCF1 complex
GO:2000672 NAS negative regulation of motor neuron apoptotic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000076140 clcf1 cardiotrophin-like cytokine factor 1 protein_coding Danio_rerio
ENSG00000175505 CLCF1 cardiotrophin-like cytokine factor 1 protein_coding Homo_sapiens

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