C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: src homology 2 domain-containing transforming protein C1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000042626 Shc1 10090 + 3:89418443-89430027 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000039110 Shc1-001 89418443-89430015 protein_coding
  ENSMUST00000094378 Shc1-002 89421628-89429099 protein_coding
  ENSMUST00000107417 Shc1-003 89418614-89430015 protein_coding
  ENSMUST00000125036 Shc1-005 89418551-89426546 protein_coding
  ENSMUST00000128238 Shc1-007 89418594-89426702 protein_coding
  ENSMUST00000137793 Shc1-008 89421642-89426702 protein_coding
  ENSMUST00000146306 Shc1-009 89424526-89427358 processed_transcript
  ENSMUST00000153334 Shc1-004 89420633-89424043 retained_intron
  ENSMUST00000154791 Shc1-006 89418571-89424244 protein_coding
  ENSMUST00000191485 Shc1-201 89418551-89430027 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000039110ENSMUST00000094378ENSMUST00000107417ENSMUST00000153334ENSMUST00000191485
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000039110 N/A N/A N/A 1.548±0.06 N/A N/A 1.485±0.00 N/A 6.382±2.18 N/A 1.127±0.00 N/A 4.904±0.00 N/A
ENSMUST00000094378 26.460±12.42 14.608±3.12 10.937±0.33 1.867±0.15 16.024±3.24 10.513±2.42 2.536±0.55 4.421±1.11 N/A 8.477±2.22 N/A 25.607±1.61 9.744±2.25 N/A
ENSMUST00000107417 32.117±2.62 18.321±3.64 N/A 2.275±1.12 25.563±12.64 13.502±4.90 2.783±0.38 8.357±1.45 13.024±8.90 12.275±1.34 4.889±2.31 26.367±8.35 13.184±3.80 N/A
ENSMUST00000153334 N/A N/A N/A 0.757±0.38 N/A N/A 1.626±0.00 N/A N/A 4.785±0.00 N/A 2.558±0.00 N/A 0.070±0.00
ENSMUST00000191485 14.485±2.45 14.282±6.58 28.858±2.80 4.404±2.11 12.585±3.93 20.816±4.34 5.956±1.14 12.684±0.86 23.333±5.91 25.545±5.19 3.864±1.82 19.202±7.52 13.635±11.06 N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000165 ISS MAPK cascade
GO:0000187 IMP:ISS activation of MAPK activity
GO:0001525 IMP angiogenesis
GO:0005158 IEA insulin receptor binding
GO:0005159 IEA insulin-like growth factor receptor binding
GO:0005168 IEA neurotrophin TRKA receptor binding
GO:0005515 IPI protein binding
GO:0005739 IEA mitochondrion
GO:0005829 TAS cytosol
GO:0005886 ISS plasma membrane
GO:0007173 IDA epidermal growth factor receptor signaling pathway
GO:0007507 IMP heart development
GO:0016337 IMP single organismal cell-cell adhesion
GO:0030971 IEA:IPI receptor tyrosine kinase binding
GO:0031532 IMP actin cytoskeleton reorganization
GO:0035556 IEA intracellular signal transduction
GO:0040008 IEA regulation of growth
GO:0042127 IMP regulation of cell proliferation
GO:0046875 IPI ephrin receptor binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000075437 shc1 SHC (Src homology 2 domain containing) transforming protein 1 protein_coding Danio_rerio
ENSG00000160691 SHC1 SHC (Src homology 2 domain containing) transforming protein 1 protein_coding Homo_sapiens

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