C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: disrupted in schizophrenia 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000043051 Disc1 10090 + 8:125054195-125261858 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000074562 Disc1-201 125054195-125261151 protein_coding
  ENSMUST00000075730 Disc1-202 125054195-125261151 protein_coding
  ENSMUST00000098311 Disc1-203 125054195-125261151 protein_coding
  ENSMUST00000115885 Disc1-204 125054195-125261151 protein_coding
  ENSMUST00000117658 Disc1-002 125054195-125261858 protein_coding
  ENSMUST00000118942 Disc1-001 125054195-125261858 protein_coding
  ENSMUST00000121953 Disc1-003 125054230-125261148 protein_coding
  ENSMUST00000122389 Disc1-004 125054209-125090995 protein_coding
  ENSMUST00000126111 Disc1-005 125087987-125102878 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000074562ENSMUST00000075730ENSMUST00000098311ENSMUST00000115885ENSMUST00000117658ENSMUST00000118942ENSMUST00000122389ENSMUST00000126111
Transcript ID Adipose Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000074562 0.317±0.00 N/A N/A 0.110±0.00 N/A N/A 0.060±0.00 N/A N/A 0.401±0.00 0.082±0.00 N/A
ENSMUST00000075730 N/A N/A N/A 0.072±0.00 N/A N/A 0.013±0.00 N/A 0.052±0.00 N/A 0.055±0.00 N/A
ENSMUST00000098311 0.318±0.00 N/A 0.330±0.05 0.110±0.00 0.227±0.00 0.202±0.05 0.041±0.02 N/A N/A 0.276±0.12 0.092±0.01 N/A
ENSMUST00000115885 N/A N/A N/A 0.072±0.00 N/A N/A 0.013±0.00 N/A 0.050±0.00 N/A 0.055±0.00 N/A
ENSMUST00000117658 N/A N/A N/A 0.191±0.00 0.237±0.00 0.174±0.00 0.088±0.01 N/A 0.052±0.00 N/A 0.133±0.00 N/A
ENSMUST00000118942 0.327±0.05 0.478±0.03 0.221±0.00 0.090±0.00 0.283±0.07 N/A 0.091±0.04 0.769±0.00 0.164±0.02 0.363±0.17 0.208±0.00 0.087±0.00
ENSMUST00000122389 N/A 0.107±0.00 N/A 0.168±0.06 N/A 0.200±0.00 0.036±0.02 N/A 0.078±0.01 0.181±0.00 0.056±0.02 0.022±0.00
ENSMUST00000126111 N/A N/A N/A N/A N/A N/A 0.024±0.00 N/A N/A 0.743±0.28 0.235±0.04 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00087G CIL_00087G_0002 VISTA 8:124917043-125519851
CIL_0006B1 CIL_0006B1_0002 CGP 8:125012997-125261858
CIL_0006B0 CIL_0006B0_0002 CGP 8:125054195-125492710

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000226 IEA microtubule cytoskeleton organization
GO:0001764 IMP neuron migration
GO:0002052 IMP positive regulation of neuroblast proliferation
GO:0005515 IPI protein binding
GO:0005739 IEA mitochondrion
GO:0005813 IMP centrosome
GO:0005874 IEA microtubule
GO:0008104 IDA protein localization
GO:0010975 IMP regulation of neuron projection development
GO:0021799 IMP cerebral cortex radially oriented cell migration
GO:0021846 IMP cell proliferation in forebrain
GO:0030054 IEA cell junction
GO:0030177 IMP positive regulation of Wnt signaling pathway
GO:0031929 IMP TOR signaling
GO:0034613 IDA cellular protein localization
GO:0036064 IDA ciliary basal body
GO:0045211 IEA postsynaptic membrane
GO:0051560 IMP mitochondrial calcium ion homeostasis
GO:0060070 IMP canonical Wnt signaling pathway
GO:0090128 IMP regulation of synapse maturation
GO:2000060 IMP positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000021895 disc1 disrupted in schizophrenia 1 protein_coding Danio_rerio
ENSG00000162946 DISC1 disrupted in schizophrenia 1 protein_coding Homo_sapiens

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