C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: disrupted in schizophrenia 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000162946 DISC1 9606 + 1:231626815-232041272 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000295051 DISC1-018 231626815-231819244 nonsense_mediated_decay
  ENST00000317586 DISC1-005 231626815-231724074 protein_coding
  ENST00000366632 DISC1-010 231626815-231855380 nonsense_mediated_decay
  ENST00000366633 DISC1-009 231626815-231855380 protein_coding
  ENST00000366636 DISC1-006 231626815-231866712 protein_coding
  ENST00000366637 DISC1-002 231626815-232041127 protein_coding
  ENST00000422590 DISC1-008 231626837-232009654 nonsense_mediated_decay
  ENST00000427560 DISC1-007 231818905-232009022 processed_transcript
  ENST00000439617 DISC1-001 231626815-232041272 protein_coding
  ENST00000468399 DISC1-003 231629390-231702661 retained_intron
  ENST00000535944 DISC1-016 231626815-231819244 nonsense_mediated_decay
  ENST00000535983 DISC1-201 231626815-232009652 protein_coding
  ENST00000537876 DISC1-202 231626815-231866685 protein_coding
  ENST00000539444 DISC1-017 231626815-231819244 protein_coding
  ENST00000602281 DISC1-019 231626815-231819244 protein_coding
  ENST00000602600 DISC1-012 231684752-231693935 processed_transcript
  ENST00000602700 DISC1-014 231626815-231819244 nonsense_mediated_decay
  ENST00000602713 DISC1-011 231626815-231855380 nonsense_mediated_decay
  ENST00000602822 DISC1-015 231626815-231819244 nonsense_mediated_decay
  ENST00000602873 DISC1-013 231626815-231819244 protein_coding
  ENST00000620189 DISC1-203 231626815-232041268 protein_coding
  ENST00000622252 DISC1-204 231626815-232041270 protein_coding

Homo sapiens EnsemblGRCh38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderBrainBreastKidneyLungMuscleOvaryPlacentaENST00000366636ENST00000366637ENST00000439617ENST00000602281ENST00000620189ENST00000622252
Transcript ID Bladder Brain Breast Kidney Lung Muscle Ovary Placenta
ENST00000366636 N/A 2.804±0.00 2.396±0.00 1.285±0.00 N/A N/A N/A N/A
ENST00000366637 N/A N/A N/A N/A 0.633±0.00 N/A 1.181±0.24 1.025±0.19
ENST00000439617 N/A N/A N/A N/A N/A 0.274±0.00 0.923±0.00 0.743±0.00
ENST00000602281 N/A N/A N/A N/A 1.883±0.00 N/A 1.585±0.00 N/A
ENST00000620189 0.317±0.00 N/A N/A N/A 1.383±0.00 N/A 0.575±0.00 1.970±0.00
ENST00000622252 N/A N/A 1.073±0.00 N/A N/A N/A 1.156±0.00 1.021±0.47

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006AY CIL_0006AY_0001 CGP 1:231363751-231819244
CIL_0006B1 CIL_0006B1_0001 CGP 1:231528653-232041272
CIL_0006B0 CIL_0006B0_0001 CGP 1:231626815-232561558

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000226 IMP microtubule cytoskeleton organization
GO:0001764 IMP neuron migration
GO:0002052 IGI positive regulation of neuroblast proliferation
GO:0005515 IPI protein binding
GO:0005739 IDA mitochondrion
GO:0005813 IDA centrosome
GO:0005874 IEA microtubule
GO:0008104 IEA protein localization
GO:0010975 IEA regulation of neuron projection development
GO:0021799 IEA cerebral cortex radially oriented cell migration
GO:0021846 IEA cell proliferation in forebrain
GO:0030054 IEA cell junction
GO:0030177 IGI positive regulation of Wnt signaling pathway
GO:0031929 IEA TOR signaling
GO:0034613 IEA cellular protein localization
GO:0036064 IEA ciliary basal body
GO:0045211 IEA postsynaptic membrane
GO:0051560 IEA mitochondrial calcium ion homeostasis
GO:0060070 IEA canonical Wnt signaling pathway
GO:0090128 IEA regulation of synapse maturation
GO:2000060 IEA positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000021895 disc1 disrupted in schizophrenia 1 protein_coding Danio_rerio
ENSMUSG00000043051 Disc1 disrupted in schizophrenia 1 protein_coding Mus_musculus

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