C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: phospholipase C, beta 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000051177 Plcb1 10090 + 2:134786159-135475258 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000070724 Plcb1-003 134786530-135399675 protein_coding
  ENSMUST00000110116 Plcb1-001 134786159-135475258 protein_coding
  ENSMUST00000129382 Plcb1-002 135220718-135262257 processed_transcript
  ENSMUST00000130524 Plcb1-004 134786175-134989373 retained_intron
  ENSMUST00000131552 Plcb1-005 135370463-135472144 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000070724ENSMUST00000110116ENSMUST00000130524ENSMUST00000131552
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000070724 N/A N/A N/A 27.097±0.00 0.603±0.38 N/A 0.139±0.00 N/A 0.178±0.00 N/A N/A 0.403±0.00 0.108±0.02 0.282±0.14
ENSMUST00000110116 1.594±0.23 3.625±0.48 0.401±0.06 10.292±10.30 0.833±0.27 0.728±0.42 0.489±0.12 1.178±0.44 0.379±0.20 2.095±0.95 0.165±0.07 0.747±0.26 0.107±0.09 0.266±0.11
ENSMUST00000130524 N/A 49.825±6.99 N/A N/A 4.504±0.14 2.505±0.32 N/A N/A 0.563±0.18 3.833±0.99 N/A 3.537±1.42 N/A N/A
ENSMUST00000131552 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.752±0.00 0.634±0.31 6.429±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006F4 CIL_0006F4_0002 CGP 2:134594185-135475258
CIL_0001PB CIL_0001PB_0002 CGP 2:134786159-136014593

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000086 NAS G2/M transition of mitotic cell cycle
GO:0000790 IDA nuclear chromatin
GO:0001556 NAS oocyte maturation
GO:0004435 IDA phosphatidylinositol phospholipase C activity
GO:0004871 IEA signal transducer activity
GO:0005096 IEA GTPase activator activity
GO:0005509 IEA calcium ion binding
GO:0005515 IPI protein binding
GO:0005516 ISS calmodulin binding
GO:0005521 IPI lamin binding
GO:0005546 ISS phosphatidylinositol-4,5-bisphosphate binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005886 TAS plasma membrane
GO:0006397 TAS mRNA processing
GO:0007155 IC cell adhesion
GO:0007165 TAS signal transduction
GO:0007213 IMP G-protein coupled acetylcholine receptor signaling pathway
GO:0007215 IMP glutamate receptor signaling pathway
GO:0007420 NAS brain development
GO:0007613 IMP memory
GO:0008277 IMP regulation of G-protein coupled receptor protein signaling pathway
GO:0008286 TAS insulin receptor signaling pathway
GO:0016042 IEA lipid catabolic process
GO:0016607 IDA nuclear speck
GO:0019899 ISS enzyme binding
GO:0021987 IMP cerebral cortex development
GO:0030218 TAS erythrocyte differentiation
GO:0030225 NAS macrophage differentiation
GO:0032417 NAS positive regulation of sodium:proton antiporter activity
GO:0032735 IMP positive regulation of interleukin-12 production
GO:0035556 IEA intracellular signal transduction
GO:0035722 ISS interleukin-12-mediated signaling pathway
GO:0035723 ISS interleukin-15-mediated signaling pathway
GO:0040019 IMP positive regulation of embryonic development
GO:0042803 ISS protein homodimerization activity
GO:0043547 IEA positive regulation of GTPase activity
GO:0045444 IDA fat cell differentiation
GO:0045663 IDA positive regulation of myoblast differentiation
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0046330 ISS positive regulation of JNK cascade
GO:0046488 ISS phosphatidylinositol metabolic process
GO:0048009 IDA insulin-like growth factor receptor signaling pathway
GO:0048639 IMP positive regulation of developmental growth
GO:0060466 IDA activation of meiosis involved in egg activation
GO:0070062 IEA extracellular vesicular exosome
GO:0070498 IEA interleukin-1-mediated signaling pathway
GO:0080154 IMP regulation of fertilization
GO:1900087 IDA positive regulation of G1/S transition of mitotic cell cycle
GO:2000344 IMP positive regulation of acrosome reaction
GO:2000438 IDA negative regulation of monocyte extravasation
GO:2000560 IDA positive regulation of CD24 biosynthetic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000090084 PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) protein_coding Danio_rerio
ENSG00000182621 PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) protein_coding Homo_sapiens

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