C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: phospholipase C, beta 1 (phosphoinositide-specific)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000182621 PLCB1 9606 + 20:8132177-8968356 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000338037 PLCB1-003 8132625-8884900 protein_coding
  ENST00000378637 PLCB1-004 8132649-8802483 protein_coding
  ENST00000378641 PLCB1-005 8132177-8884900 protein_coding
  ENST00000404098 PLCB1-001 8132655-8651518 protein_coding
  ENST00000437439 PLCB1-008 8790178-8792790 protein_coding
  ENST00000439627 PLCB1-007 8737028-8751236 protein_coding
  ENST00000475958 PLCB1-009 8649391-8652011 processed_transcript
  ENST00000487210 PLCB1-002 8658621-8968356 nonsense_mediated_decay
  ENST00000494924 PLCB1-006 8715862-8788525 processed_transcript
  ENST00000612075 PLCB1-201 8628288-8884896 protein_coding
  ENST00000617005 PLCB1-202 8628288-8884896 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000338037ENST00000378637ENST00000378641ENST00000404098ENST00000487210ENST00000612075ENST00000617005
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000338037 N/A N/A 0.387±0.00 5.338±3.27 N/A 0.991±0.00 0.285±0.17 N/A 0.436±0.23 N/A N/A 2.107±0.00 0.364±0.12 N/A
ENST00000378637 0.458±0.00 N/A 1.879±0.00 8.070±0.00 2.279±0.00 N/A 0.311±0.00 N/A 1.791±0.00 1.286±0.00 N/A 1.577±0.00 N/A 0.373±0.00
ENST00000378641 1.345±0.00 0.344±0.00 0.914±0.00 5.582±1.26 1.322±0.76 N/A 0.577±0.00 2.165±0.00 1.752±0.00 1.087±0.35 0.580±0.06 1.841±0.68 0.658±0.29 N/A
ENST00000404098 N/A N/A 8.527±0.00 N/A N/A 5.515±0.00 N/A N/A 12.837±0.00 N/A 8.335±0.00 11.336±0.00 N/A N/A
ENST00000487210 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.238±0.00 N/A N/A
ENST00000612075 N/A 1.115±0.00 N/A 5.414±0.00 1.025±0.00 1.702±0.94 N/A N/A 0.380±0.00 0.894±0.00 N/A 1.357±0.15 0.441±0.19 1.586±0.00
ENST00000617005 N/A N/A N/A 6.376±0.00 N/A 1.230±0.00 N/A 0.795±0.00 N/A N/A N/A N/A 1.206±0.00 0.256±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006F4 CIL_0006F4_0001 CGP 20:7977348-8968356
CIL_0001PB CIL_0001PB_0001 CGP 20:8132177-9481242

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000086 ISS G2/M transition of mitotic cell cycle
GO:0000790 ISS nuclear chromatin
GO:0004435 ISS:IEA phosphatidylinositol phospholipase C activity
GO:0004871 IEA signal transducer activity
GO:0005096 IDA GTPase activator activity
GO:0005509 IEA calcium ion binding
GO:0005515 IEA protein binding
GO:0005516 IPI calmodulin binding
GO:0005521 IEA lamin binding
GO:0005546 IDA phosphatidylinositol-4,5-bisphosphate binding
GO:0005634 NAS nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006629 IEA lipid metabolic process
GO:0007165 NAS:IEA signal transduction
GO:0007213 ISS G-protein coupled acetylcholine receptor signaling pathway
GO:0007215 ISS glutamate receptor signaling pathway
GO:0007268 TAS synaptic transmission
GO:0007420 IEA brain development
GO:0007613 ISS memory
GO:0008081 IEA phosphoric diester hydrolase activity
GO:0008152 IEA metabolic process
GO:0008277 ISS regulation of G-protein coupled receptor protein signaling pathway
GO:0016020 IEA membrane
GO:0016042 IEA lipid catabolic process
GO:0016607 IDA nuclear speck
GO:0019899 IPI enzyme binding
GO:0021987 ISS cerebral cortex development
GO:0032735 ISS positive regulation of interleukin-12 production
GO:0035556 IEA intracellular signal transduction
GO:0035722 IDA interleukin-12-mediated signaling pathway
GO:0035723 IDA interleukin-15-mediated signaling pathway
GO:0040019 ISS positive regulation of embryonic development
GO:0042803 ISS protein homodimerization activity
GO:0043547 IDA positive regulation of GTPase activity
GO:0043647 TAS inositol phosphate metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0045444 IEA fat cell differentiation
GO:0045663 ISS positive regulation of myoblast differentiation
GO:0045892 ISS negative regulation of transcription, DNA-templated
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0046330 IDA positive regulation of JNK cascade
GO:0046488 ISS phosphatidylinositol metabolic process
GO:0048009 ISS insulin-like growth factor receptor signaling pathway
GO:0048639 ISS positive regulation of developmental growth
GO:0051726 IEA regulation of cell cycle
GO:0060466 ISS activation of meiosis involved in egg activation
GO:0070062 IDA extracellular vesicular exosome
GO:0070498 IDA interleukin-1-mediated signaling pathway
GO:0080154 ISS regulation of fertilization
GO:1900087 ISS positive regulation of G1/S transition of mitotic cell cycle
GO:2000344 ISS positive regulation of acrosome reaction
GO:2000438 ISS negative regulation of monocyte extravasation
GO:2000560 ISS positive regulation of CD24 biosynthetic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000090084 PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) protein_coding Danio_rerio
ENSMUSG00000051177 Plcb1 phospholipase C, beta 1 protein_coding Mus_musculus

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