C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: phosphodiesterase 5A, cGMP-specific
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000066728 Pde5a-201 ENSMUSG00000053965 10090 + 3:122729158-122859374 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000066728
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000066728 5.561±5.01 2.847±0.93 55.524±1.67 0.783±0.49 0.708±0.38 1.909±0.21 0.397±0.28 0.696±0.34 0.551±0.50 13.502±8.22 0.338±0.14 3.001±2.30 0.812±0.70 0.254±0.14

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0004112 IDA cyclic-nucleotide phosphodiesterase activity
GO:0004114 IMP 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0007165 IEA signal transduction
GO:0010613 IMP positive regulation of cardiac muscle hypertrophy
GO:0030553 IDA cGMP binding
GO:0030823 IGI regulation of cGMP metabolic process
GO:0042130 IMP negative regulation of T cell proliferation
GO:0043406 IMP positive regulation of MAP kinase activity
GO:0045745 IC positive regulation of G-protein coupled receptor protein signaling pathway
GO:0046068 IMP cGMP metabolic process
GO:0046069 IEA cGMP catabolic process
GO:0046872 IEA metal ion binding
GO:0047555 IEA 3',5'-cyclic-GMP phosphodiesterase activity
GO:0055118 IMP negative regulation of cardiac muscle contraction
GO:0055119 IMP relaxation of cardiac muscle
GO:0060282 IGI positive regulation of oocyte development

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000264805 PDE5A-002 protein_coding Homo_sapiens 0 3103
ENST00000354960 PDE5A-001 protein_coding Homo_sapiens 0 3205
ENST00000394439 PDE5A-201 protein_coding Homo_sapiens 0 3099
ENST00000420633 PDE5A-003 protein_coding Homo_sapiens 0 872
ENST00000503412 PDE5A-005 protein_coding Homo_sapiens 0 710
ENST00000509612 PDE5A-009 retained_intron Homo_sapiens 0 254
ENST00000512450 PDE5A-012 processed_transcript Homo_sapiens 0 448
ENST00000512494 PDE5A-006 retained_intron Homo_sapiens 0 283
ENST00000512739 PDE5A-008 processed_transcript Homo_sapiens 0 614
ENST00000513594 PDE5A-011 processed_transcript Homo_sapiens 0 545

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