C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: neurotrophic tyrosine kinase, receptor, type 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000055254 Ntrk2 10090 + 13:58806596-59133970 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000079828 Ntrk2-201 58807900-59133970 protein_coding
  ENSMUST00000109838 Ntrk2-202 58806596-58937030 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000079828ENSMUST00000109838
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000079828 N/A N/A N/A 10.600±6.17 N/A N/A N/A N/A 0.025±0.00 N/A N/A N/A N/A 0.070±0.01
ENSMUST00000109838 18.293±0.37 2.790±1.78 0.308±0.06 10.495±6.44 14.428±8.09 0.251±0.03 0.283±0.09 0.459±0.14 0.447±0.45 2.011±0.40 0.235±0.10 3.555±0.75 0.176±0.15 0.198±0.07

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006HO CIL_0006HO_0002 CGP 13:58545399-59133970
CIL_0008PD CIL_0008PD_0002 VISTA 13:58790184-59394158
CIL_00092Z CIL_00092Z_0002 VISTA 13:58791170-59393172
CIL_00007E CIL_00007E_0003 CGP 13:58806596-59585227

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001570 IMP vasculogenesis
GO:0001764 IMP neuron migration
GO:0004714 IEA transmembrane receptor protein tyrosine kinase activity
GO:0005030 IEA neurotrophin receptor activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005737 IEA cytoplasm
GO:0005768 IDA endosome
GO:0005791 IEA rough endoplasmic reticulum
GO:0005829 IDA cytosol
GO:0005886 IDA plasma membrane
GO:0005887 ISS integral component of plasma membrane
GO:0006954 IEA inflammatory response
GO:0007528 IMP neuromuscular junction development
GO:0007568 IEA aging
GO:0007612 IMP learning
GO:0007616 IEA long-term memory
GO:0007623 IEP circadian rhythm
GO:0007631 IMP feeding behavior
GO:0008284 ISS positive regulation of cell proliferation
GO:0009416 IEA response to light stimulus
GO:0009986 IEA cell surface
GO:0010628 IMP positive regulation of gene expression
GO:0010976 IDA positive regulation of neuron projection development
GO:0010996 IEA response to auditory stimulus
GO:0014047 IPI glutamate secretion
GO:0014068 ISS positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014069 IEA postsynaptic density
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0019222 IMP regulation of metabolic process
GO:0021954 IMP central nervous system neuron development
GO:0021987 IMP cerebral cortex development
GO:0030182 IMP neuron differentiation
GO:0030424 IEA axon
GO:0030425 IEA dendrite
GO:0030426 IEA growth cone
GO:0031547 IDA brain-derived neurotrophic factor receptor signaling pathway
GO:0032314 IDA regulation of Rac GTPase activity
GO:0033138 IMP positive regulation of peptidyl-serine phosphorylation
GO:0035584 IMP calcium-mediated signaling using intracellular calcium source
GO:0042490 IMP mechanoreceptor differentiation
GO:0042803 ISS protein homodimerization activity
GO:0043025 IEA neuronal cell body
GO:0043121 ISS neurotrophin binding
GO:0043195 IDA terminal bouton
GO:0043197 IEA dendritic spine
GO:0043204 IEA perikaryon
GO:0043235 ISO receptor complex
GO:0043408 IEA regulation of MAPK cascade
GO:0043410 ISS positive regulation of MAPK cascade
GO:0043524 ISS negative regulation of neuron apoptotic process
GO:0043679 IEA axon terminus
GO:0045211 IDA postsynaptic membrane
GO:0046548 IMP retinal rod cell development
GO:0046777 ISS protein autophosphorylation
GO:0046875 IEA ephrin receptor binding
GO:0046928 IEA regulation of neurotransmitter secretion
GO:0048403 IDA brain-derived neurotrophic factor binding
GO:0048709 IMP oligodendrocyte differentiation
GO:0048786 IEA presynaptic active zone
GO:0048935 IMP peripheral nervous system neuron development
GO:0050772 ISS positive regulation of axonogenesis
GO:0050773 IEA regulation of dendrite development
GO:0051896 IMP regulation of protein kinase B signaling
GO:0051968 IEA positive regulation of synaptic transmission, glutamatergic
GO:0060076 IEA excitatory synapse
GO:0060175 IDA brain-derived neurotrophic factor-activated receptor activity
GO:0060291 IMP long-term synaptic potentiation
GO:0071356 IEA cellular response to tumor necrosis factor
GO:0097481 IDA neuronal postsynaptic density
GO:1990090 IEA cellular response to nerve growth factor stimulus
GO:2000811 IDA negative regulation of anoikis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000059645 ntrk2b neurotrophic tyrosine kinase, receptor, type 2b protein_coding Danio_rerio
ENSDARG00000059897 ntrk2a neurotrophic tyrosine kinase, receptor, type 2a protein_coding Danio_rerio
ENSG00000148053 NTRK2 neurotrophic tyrosine kinase, receptor, type 2 protein_coding Homo_sapiens

Loading