C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: neurotrophic tyrosine kinase, receptor, type 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000148053 NTRK2 9606 + 9:84668551-85027070 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000277120 NTRK2-004 84669778-85027070 protein_coding
  ENST00000304053 NTRK2-003 84669778-84877898 protein_coding
  ENST00000323115 NTRK2-001 84670396-85022323 protein_coding
  ENST00000359847 NTRK2-005 84670660-84815702 protein_coding
  ENST00000376208 NTRK2-002 84669778-84877898 protein_coding
  ENST00000376213 NTRK2-201 84668551-85023590 protein_coding
  ENST00000376214 NTRK2-202 84668551-85023590 protein_coding
  ENST00000395882 NTRK2-203 84669711-84815706 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000277120ENST00000323115ENST00000359847ENST00000376213ENST00000395882
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000277120 N/A N/A N/A 23.341±4.45 N/A N/A N/A 0.080±0.00 N/A N/A N/A N/A N/A N/A
ENST00000323115 N/A N/A N/A 33.043±0.00 N/A 0.563±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000359847 2.266±0.00 4.529±0.00 7.015±0.00 57.660±12.18 5.999±0.43 1.395±0.40 1.229±0.11 3.574±2.99 6.342±0.00 1.207±0.07 0.759±0.41 3.258±2.56 0.420±0.19 5.041±3.66
ENST00000376213 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.397±0.00 N/A N/A N/A
ENST00000395882 9.087±0.00 1.651±0.00 N/A 58.515±0.00 22.317±0.00 2.440±0.00 0.846±0.64 4.445±0.00 0.205±0.00 4.610±0.00 0.960±0.00 1.830±0.84 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006HO CIL_0006HO_0001 CGP 9:84275457-85027070
CIL_00007E CIL_00007E_0002 CGP 9:84668551-85742029

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001570 IEA vasculogenesis
GO:0001764 ISS neuron migration
GO:0004672 IEA protein kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0004714 IEA transmembrane receptor protein tyrosine kinase activity
GO:0005030 IEA neurotrophin receptor activity
GO:0005515 IEA protein binding
GO:0005524 IEA ATP binding
GO:0005737 IEA cytoplasm
GO:0005768 IEA endosome
GO:0005791 IEA rough endoplasmic reticulum
GO:0005829 IEA cytosol
GO:0005886 IEA plasma membrane
GO:0005887 IDA integral component of plasma membrane
GO:0006468 IEA protein phosphorylation
GO:0006954 IEA inflammatory response
GO:0007169 TAS transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007190 TAS activation of adenylate cyclase activity
GO:0007528 IEA neuromuscular junction development
GO:0007568 IEA aging
GO:0007612 ISS learning
GO:0007616 IEA long-term memory
GO:0007623 IEA circadian rhythm
GO:0007631 IEA feeding behavior
GO:0008284 ISS positive regulation of cell proliferation
GO:0009416 IEA response to light stimulus
GO:0009986 IEA cell surface
GO:0010628 ISS positive regulation of gene expression
GO:0010976 ISS positive regulation of neuron projection development
GO:0010996 IEA response to auditory stimulus
GO:0014047 IEA glutamate secretion
GO:0014068 ISS positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014069 IEA postsynaptic density
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0019222 IEA regulation of metabolic process
GO:0021954 ISS central nervous system neuron development
GO:0021987 ISS cerebral cortex development
GO:0030182 ISS neuron differentiation
GO:0030424 IEA axon
GO:0030425 IEA dendrite
GO:0030426 IEA growth cone
GO:0031547 IMP brain-derived neurotrophic factor receptor signaling pathway
GO:0032314 ISS regulation of Rac GTPase activity
GO:0033138 IEA positive regulation of peptidyl-serine phosphorylation
GO:0035584 IEA calcium-mediated signaling using intracellular calcium source
GO:0042490 IEA mechanoreceptor differentiation
GO:0042803 ISS protein homodimerization activity
GO:0043025 IEA neuronal cell body
GO:0043121 ISS neurotrophin binding
GO:0043195 IEA terminal bouton
GO:0043197 IEA dendritic spine
GO:0043204 IEA perikaryon
GO:0043235 IDA receptor complex
GO:0043408 IEA regulation of MAPK cascade
GO:0043410 ISS positive regulation of MAPK cascade
GO:0043524 ISS negative regulation of neuron apoptotic process
GO:0043679 IEA axon terminus
GO:0045211 IEA postsynaptic membrane
GO:0046548 IEA retinal rod cell development
GO:0046777 ISS protein autophosphorylation
GO:0046875 IEA ephrin receptor binding
GO:0046928 IEA regulation of neurotransmitter secretion
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048403 ISS brain-derived neurotrophic factor binding
GO:0048709 IEA oligodendrocyte differentiation
GO:0048786 IEA presynaptic active zone
GO:0048935 IEA peripheral nervous system neuron development
GO:0050772 ISS positive regulation of axonogenesis
GO:0050773 IEA regulation of dendrite development
GO:0051896 IEA regulation of protein kinase B signaling
GO:0051968 IEA positive regulation of synaptic transmission, glutamatergic
GO:0060076 IEA excitatory synapse
GO:0060175 IMP brain-derived neurotrophic factor-activated receptor activity
GO:0060291 IEA long-term synaptic potentiation
GO:0071356 IEA cellular response to tumor necrosis factor
GO:0097481 IEA neuronal postsynaptic density
GO:1990090 IEA cellular response to nerve growth factor stimulus
GO:2000811 IEA negative regulation of anoikis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000059645 ntrk2b neurotrophic tyrosine kinase, receptor, type 2b protein_coding Danio_rerio
ENSDARG00000059897 ntrk2a neurotrophic tyrosine kinase, receptor, type 2a protein_coding Danio_rerio
ENSMUSG00000055254 Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 protein_coding Mus_musculus

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