C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: insulin degrading enzyme
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000056999 Ide 10090 - 19:37268743-37337852 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000131070 Ide-001 37268743-37330613 protein_coding
  ENSMUST00000134740 Ide-005 37280584-37290878 retained_intron
  ENSMUST00000150707 Ide-006 37303346-37313573 processed_transcript
  ENSMUST00000154308 Ide-002 37303650-37337852 retained_intron
  ENSMUST00000154339 Ide-003 37270430-37307392 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000131070ENSMUST00000134740ENSMUST00000154308ENSMUST00000154339
Transcript ID Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000131070 5.389±0.00 5.656±2.08 3.679±1.18 4.981±1.98 1.529±0.64 4.556±0.00 6.327±0.00 2.643±0.73 1.991±0.00 9.174±3.05 13.480±10.17 6.472±2.28 16.945±6.64
ENSMUST00000134740 N/A N/A N/A 21.577±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000154308 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 7.271±0.00 3.990±0.00 16.986±3.41
ENSMUST00000154339 N/A N/A N/A 6.754±0.00 N/A 3.869±0.00 N/A N/A N/A N/A 7.668±0.00 4.119±0.00 23.879±6.19

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007VX CIL_0007VX_0002 VISTA 19:37192022-37797349
CIL_00018P CIL_00018P_0002 CGP 19:37207543-37337852
CIL_00018U CIL_00018U_0002 CGP 19:37268743-37421859

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001540 IEA beta-amyloid binding
GO:0001948 IEA glycoprotein binding
GO:0004222 IEA metalloendopeptidase activity
GO:0005102 IEA receptor binding
GO:0005515 IEA protein binding
GO:0005524 IEA ATP binding
GO:0005615 IEA extracellular space
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0005739 IEA mitochondrion
GO:0005777 IEA peroxisome
GO:0005782 IEA peroxisomal matrix
GO:0005829 IEA cytosol
GO:0006200 IEA ATP catabolic process
GO:0006508 IEA proteolysis
GO:0008270 IEA zinc ion binding
GO:0008340 IEA determination of adult lifespan
GO:0009986 IEA cell surface
GO:0010815 IEA bradykinin catabolic process
GO:0010992 IEA ubiquitin homeostasis
GO:0016887 IEA ATPase activity
GO:0017046 IEA peptide hormone binding
GO:0031597 IEA cytosolic proteasome complex
GO:0031626 IEA beta-endorphin binding
GO:0032461 IEA positive regulation of protein oligomerization
GO:0042277 IEA peptide binding
GO:0042447 IEA hormone catabolic process
GO:0042803 IEA protein homodimerization activity
GO:0043130 IEA ubiquitin binding
GO:0043559 IEA insulin binding
GO:0044257 IEA cellular protein catabolic process
GO:0045861 IEA negative regulation of proteolysis
GO:0050435 IEA beta-amyloid metabolic process
GO:0051260 IEA protein homooligomerization
GO:0051289 IEA protein homotetramerization
GO:0051291 IEA protein heterooligomerization
GO:0051603 IEA proteolysis involved in cellular protein catabolic process
GO:1901142 IEA insulin metabolic process
GO:1901143 IEA insulin catabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000075570 ide insulin-degrading enzyme protein_coding Danio_rerio
ENSG00000119912 IDE insulin-degrading enzyme protein_coding Homo_sapiens

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