C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: B cell leukemia/lymphoma 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000057329 Bcl2 10090 - 1:106538178-106714274 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000112751 Bcl2-001 106538178-106714274 protein_coding
  ENSMUST00000189999 Bcl2-002 106710339-106713179 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000112751ENSMUST00000189999
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000112751 1.880±1.00 0.571±0.19 1.921±0.35 1.607±0.59 1.685±0.78 1.259±0.16 0.534±0.06 0.927±0.17 0.196±0.09 1.497±0.17 0.309±0.20 1.170±0.41 0.304±0.11 0.069±0.02
ENSMUST00000189999 1.238±0.62 1.085±0.15 N/A N/A 3.249±2.17 2.156±0.38 0.300±0.08 0.679±0.06 0.132±0.07 1.878±0.18 N/A 2.477±0.55 0.113±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00076I CIL_00076I_0002 CGP 1:106171752-106714274
CIL_0000B4 CIL_0000B4_0003 CGP 1:106538178-106759727

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000209 ISO protein polyubiquitination
GO:0000902 IMP cell morphogenesis
GO:0001503 IMP ossification
GO:0001541 IMP ovarian follicle development
GO:0001656 IMP metanephros development
GO:0001657 IMP ureteric bud development
GO:0001658 IDA branching involved in ureteric bud morphogenesis
GO:0001662 IMP behavioral fear response
GO:0001776 IMP leukocyte homeostasis
GO:0001782 IMP B cell homeostasis
GO:0001822 IGI kidney development
GO:0001836 IDA release of cytochrome c from mitochondria
GO:0001952 IMP regulation of cell-matrix adhesion
GO:0002020 IEA protease binding
GO:0002260 IGI lymphocyte homeostasis
GO:0002320 IMP lymphoid progenitor cell differentiation
GO:0002326 IMP B cell lineage commitment
GO:0002360 IMP T cell lineage commitment
GO:0002520 IMP immune system development
GO:0002931 IMP response to ischemia
GO:0003014 IMP renal system process
GO:0005515 IPI protein binding
GO:0005622 IDA intracellular
GO:0005634 ISO nucleus
GO:0005737 ISO cytoplasm
GO:0005739 IDA mitochondrion
GO:0005741 IBA mitochondrial outer membrane
GO:0005783 IDA endoplasmic reticulum
GO:0005789 IDA endoplasmic reticulum membrane
GO:0005829 IDA cytosol
GO:0006470 IDA protein dephosphorylation
GO:0006582 IMP melanin metabolic process
GO:0006808 IGI regulation of nitrogen utilization
GO:0006874 IDA cellular calcium ion homeostasis
GO:0006915 ISO apoptotic process
GO:0006974 IEA cellular response to DNA damage stimulus
GO:0006979 IMP response to oxidative stress
GO:0007015 IMP actin filament organization
GO:0007409 IMP axonogenesis
GO:0007569 IMP cell aging
GO:0008134 IPI transcription factor binding
GO:0008283 IGI cell proliferation
GO:0008284 IDA positive regulation of cell proliferation
GO:0008285 IMP negative regulation of cell proliferation
GO:0008584 IGI male gonad development
GO:0008625 ISO extrinsic apoptotic signaling pathway via death domain receptors
GO:0008630 IBA intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008631 IMP intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0008637 IDA apoptotic mitochondrial changes
GO:0009636 IMP response to toxic substance
GO:0009791 IMP post-embryonic development
GO:0009887 IMP organ morphogenesis
GO:0010039 IEA response to iron ion
GO:0010224 IMP response to UV-B
GO:0010332 IMP response to gamma radiation
GO:0010468 IMP regulation of gene expression
GO:0010523 IGI negative regulation of calcium ion transport into cytosol
GO:0010559 IMP regulation of glycoprotein biosynthetic process
GO:0014031 IMP mesenchymal cell development
GO:0014042 IMP positive regulation of neuron maturation
GO:0014911 IMP positive regulation of smooth muscle cell migration
GO:0015267 IEA channel activity
GO:0016020 ISO membrane
GO:0016049 IMP cell growth
GO:0016248 IEA channel inhibitor activity
GO:0016337 IMP single organismal cell-cell adhesion
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0018107 IDA peptidyl-threonine phosphorylation
GO:0019903 IDA protein phosphatase binding
GO:0021747 IMP cochlear nucleus development
GO:0022612 IMP gland morphogenesis
GO:0022898 IEA regulation of transmembrane transporter activity
GO:0030097 IMP hemopoiesis
GO:0030183 IMP B cell differentiation
GO:0030217 IMP T cell differentiation
GO:0030279 IMP negative regulation of ossification
GO:0030307 ISO positive regulation of cell growth
GO:0030308 IMP negative regulation of cell growth
GO:0030318 IMP melanocyte differentiation
GO:0030336 IMP negative regulation of cell migration
GO:0030890 IEA positive regulation of B cell proliferation
GO:0031069 IMP hair follicle morphogenesis
GO:0031103 IDA axon regeneration
GO:0031625 IEA ubiquitin protein ligase binding
GO:0031647 IMP regulation of protein stability
GO:0031965 IDA nuclear membrane
GO:0031966 IDA mitochondrial membrane
GO:0032469 IGI endoplasmic reticulum calcium ion homeostasis
GO:0032835 IMP glomerulus development
GO:0032848 IEA negative regulation of cellular pH reduction
GO:0032880 IMP regulation of protein localization
GO:0033033 IDA negative regulation of myeloid cell apoptotic process
GO:0033077 IMP T cell differentiation in thymus
GO:0033138 IGI positive regulation of peptidyl-serine phosphorylation
GO:0033689 IMP negative regulation of osteoblast proliferation
GO:0034097 IMP response to cytokine
GO:0035094 IEA response to nicotine
GO:0035265 IMP organ growth
GO:0040007 IMP growth
GO:0040018 IMP positive regulation of multicellular organism growth
GO:0042100 ISO B cell proliferation
GO:0042149 IDA cellular response to glucose starvation
GO:0042493 ISO response to drug
GO:0042542 IMP response to hydrogen peroxide
GO:0042802 IEA identical protein binding
GO:0042803 IBA protein homodimerization activity
GO:0042981 IGI regulation of apoptotic process
GO:0043029 IGI T cell homeostasis
GO:0043066 IMP negative regulation of apoptotic process
GO:0043067 IGI regulation of programmed cell death
GO:0043085 IMP positive regulation of catalytic activity
GO:0043209 IDA myelin sheath
GO:0043375 IMP CD8-positive, alpha-beta T cell lineage commitment
GO:0043473 IMP pigmentation
GO:0043496 IEA regulation of protein homodimerization activity
GO:0043497 IEA regulation of protein heterodimerization activity
GO:0043524 IMP negative regulation of neuron apoptotic process
GO:0043565 IEA sequence-specific DNA binding
GO:0043583 IGI ear development
GO:0045069 IDA regulation of viral genome replication
GO:0045636 IMP positive regulation of melanocyte differentiation
GO:0045930 IDA negative regulation of mitotic cell cycle
GO:0046671 IMP negative regulation of retinal cell programmed cell death
GO:0046902 IDA regulation of mitochondrial membrane permeability
GO:0046930 IEA pore complex
GO:0046982 IPI protein heterodimerization activity
GO:0048041 IMP focal adhesion assembly
GO:0048066 IGI developmental pigmentation
GO:0048070 IGI regulation of developmental pigmentation
GO:0048087 IMP positive regulation of developmental pigmentation
GO:0048536 IGI spleen development
GO:0048538 IGI thymus development
GO:0048545 IMP response to steroid hormone
GO:0048546 IMP digestive tract morphogenesis
GO:0048589 IMP developmental growth
GO:0048599 IMP oocyte development
GO:0048743 IMP positive regulation of skeletal muscle fiber development
GO:0048753 IMP pigment granule organization
GO:0048873 IMP homeostasis of number of cells within a tissue
GO:0050790 IMP regulation of catalytic activity
GO:0050853 IEA B cell receptor signaling pathway
GO:0051384 IDA response to glucocorticoid
GO:0051402 IGI neuron apoptotic process
GO:0051434 IEA BH3 domain binding
GO:0051607 IEA defense response to virus
GO:0051721 IDA protein phosphatase 2A binding
GO:0051726 IMP regulation of cell cycle
GO:0051881 IDA regulation of mitochondrial membrane potential
GO:0051924 ISO regulation of calcium ion transport
GO:0055085 IEA transmembrane transport
GO:0070059 ISS intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0071310 IDA cellular response to organic substance
GO:0071456 IDA cellular response to hypoxia
GO:0072593 IMP reactive oxygen species metabolic process
GO:0097192 IGI extrinsic apoptotic signaling pathway in absence of ligand
GO:2000134 IMP negative regulation of G1/S transition of mitotic cell cycle
GO:2000811 IEA negative regulation of anoikis
GO:2001234 IDA negative regulation of apoptotic signaling pathway
GO:2001240 IEA negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243 IBA negative regulation of intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000025613 bcl2 B-cell leukemia/lymphoma 2 protein_coding Danio_rerio
ENSDARG00000089109 BCL2 (2 of 2) B-cell CLL/lymphoma 2 protein_coding Danio_rerio
ENSG00000171791 BCL2 B-cell CLL/lymphoma 2 protein_coding Homo_sapiens

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