C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: B-cell CLL/lymphoma 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000171791 BCL2 9606 - 18:63123346-63320128 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000333681 BCL2-002 63127035-63319786 protein_coding
  ENST00000398117 BCL2-001 63123346-63320128 protein_coding
  ENST00000589955 BCL2-003 63317902-63318812 protein_coding
  ENST00000590515 BCL2-004 63128212-63161869 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000333681ENST00000398117
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000333681 N/A N/A 2.974±0.00 0.683±0.00 N/A 2.113±0.00 0.294±0.00 N/A 1.274±0.00 1.276±0.00 1.462±0.32 0.902±0.00 1.114±0.00 N/A
ENST00000398117 2.436±0.00 1.361±0.00 1.522±0.00 1.352±0.30 2.929±0.19 1.369±0.80 0.459±0.09 0.127±0.00 0.757±0.70 1.283±0.07 0.517±0.00 0.916±0.48 0.629±0.19 1.081±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00076I CIL_00076I_0001 CGP 18:62715450-63320128
CIL_0000B4 CIL_0000B4_0002 CGP 18:63123346-63367510

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000209 IDA protein polyubiquitination
GO:0000902 IEA cell morphogenesis
GO:0001503 IEA ossification
GO:0001541 IEA ovarian follicle development
GO:0001656 IEA metanephros development
GO:0001657 IEA ureteric bud development
GO:0001658 IEA branching involved in ureteric bud morphogenesis
GO:0001662 IEA behavioral fear response
GO:0001776 IEA leukocyte homeostasis
GO:0001782 IEA B cell homeostasis
GO:0001822 IEA kidney development
GO:0001836 NAS release of cytochrome c from mitochondria
GO:0001952 IEA regulation of cell-matrix adhesion
GO:0002020 IDA protease binding
GO:0002260 IEA lymphocyte homeostasis
GO:0002320 IEA lymphoid progenitor cell differentiation
GO:0002326 IEA B cell lineage commitment
GO:0002360 IEA T cell lineage commitment
GO:0002520 IEA immune system development
GO:0002931 IEA response to ischemia
GO:0003014 IEA renal system process
GO:0005515 IPI protein binding
GO:0005622 IEA intracellular
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005739 IDA mitochondrion
GO:0005741 IDA mitochondrial outer membrane
GO:0005783 IDA endoplasmic reticulum
GO:0005789 IEA endoplasmic reticulum membrane
GO:0005829 IEA cytosol
GO:0006470 IEA protein dephosphorylation
GO:0006582 IEA melanin metabolic process
GO:0006808 IEA regulation of nitrogen utilization
GO:0006874 IEA cellular calcium ion homeostasis
GO:0006915 IDA apoptotic process
GO:0006959 TAS humoral immune response
GO:0006974 IMP cellular response to DNA damage stimulus
GO:0006979 IEA response to oxidative stress
GO:0007015 IEA actin filament organization
GO:0007409 IEA axonogenesis
GO:0007565 NAS female pregnancy
GO:0007569 IEA cell aging
GO:0008134 IEA transcription factor binding
GO:0008283 IEA cell proliferation
GO:0008284 IEA positive regulation of cell proliferation
GO:0008285 IEA negative regulation of cell proliferation
GO:0008584 IEA male gonad development
GO:0008625 IDA extrinsic apoptotic signaling pathway via death domain receptors
GO:0008630 IBA intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008631 IEA intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0008637 IEA apoptotic mitochondrial changes
GO:0009314 NAS response to radiation
GO:0009636 IDA response to toxic substance
GO:0009791 IEA post-embryonic development
GO:0009887 IEA organ morphogenesis
GO:0010039 IDA response to iron ion
GO:0010224 IEA response to UV-B
GO:0010332 IEA response to gamma radiation
GO:0010468 IEA regulation of gene expression
GO:0010507 TAS negative regulation of autophagy
GO:0010523 IEA negative regulation of calcium ion transport into cytosol
GO:0010559 IEA regulation of glycoprotein biosynthetic process
GO:0014031 IEA mesenchymal cell development
GO:0014042 IEA positive regulation of neuron maturation
GO:0014911 IEA positive regulation of smooth muscle cell migration
GO:0015267 IDA channel activity
GO:0016020 IDA:IEA membrane
GO:0016049 IEA cell growth
GO:0016248 IDA channel inhibitor activity
GO:0016337 IEA single organismal cell-cell adhesion
GO:0018105 IEA peptidyl-serine phosphorylation
GO:0018107 IEA peptidyl-threonine phosphorylation
GO:0019903 IEA protein phosphatase binding
GO:0021747 IEA cochlear nucleus development
GO:0022612 IEA gland morphogenesis
GO:0022898 IDA regulation of transmembrane transporter activity
GO:0030097 IEA hemopoiesis
GO:0030183 IEA B cell differentiation
GO:0030217 IEA T cell differentiation
GO:0030279 IEA negative regulation of ossification
GO:0030307 IDA positive regulation of cell growth
GO:0030308 IEA negative regulation of cell growth
GO:0030318 IEA melanocyte differentiation
GO:0030336 IEA negative regulation of cell migration
GO:0030890 IMP positive regulation of B cell proliferation
GO:0031069 IEA hair follicle morphogenesis
GO:0031103 IEA axon regeneration
GO:0031625 IPI ubiquitin protein ligase binding
GO:0031647 IEA regulation of protein stability
GO:0031965 IDA nuclear membrane
GO:0031966 IEA mitochondrial membrane
GO:0032469 TAS endoplasmic reticulum calcium ion homeostasis
GO:0032835 IEA glomerulus development
GO:0032848 IDA negative regulation of cellular pH reduction
GO:0032880 IEA regulation of protein localization
GO:0033033 IEA negative regulation of myeloid cell apoptotic process
GO:0033077 IEA T cell differentiation in thymus
GO:0033138 IEA positive regulation of peptidyl-serine phosphorylation
GO:0033689 IEA negative regulation of osteoblast proliferation
GO:0034097 IDA response to cytokine
GO:0035094 IDA response to nicotine
GO:0035265 IEA organ growth
GO:0035872 TAS nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0040007 IEA growth
GO:0040018 IEA positive regulation of multicellular organism growth
GO:0042100 IDA B cell proliferation
GO:0042149 IEA cellular response to glucose starvation
GO:0042493 IMP response to drug
GO:0042542 IEA response to hydrogen peroxide
GO:0042802 IPI identical protein binding
GO:0042803 IPI protein homodimerization activity
GO:0042981 IEA regulation of apoptotic process
GO:0043029 IEA T cell homeostasis
GO:0043066 IDA negative regulation of apoptotic process
GO:0043067 IEA regulation of programmed cell death
GO:0043085 IEA positive regulation of catalytic activity
GO:0043209 IEA myelin sheath
GO:0043375 IEA CD8-positive, alpha-beta T cell lineage commitment
GO:0043473 IEA pigmentation
GO:0043496 IDA regulation of protein homodimerization activity
GO:0043497 IDA regulation of protein heterodimerization activity
GO:0043524 IDA negative regulation of neuron apoptotic process
GO:0043565 IDA sequence-specific DNA binding
GO:0043583 IEA ear development
GO:0045069 IEA regulation of viral genome replication
GO:0045087 TAS innate immune response
GO:0045636 IEA positive regulation of melanocyte differentiation
GO:0045930 IEA negative regulation of mitotic cell cycle
GO:0046671 IEA negative regulation of retinal cell programmed cell death
GO:0046902 ISS regulation of mitochondrial membrane permeability
GO:0046930 IDA pore complex
GO:0046982 IPI protein heterodimerization activity
GO:0048041 IEA focal adhesion assembly
GO:0048066 IEA developmental pigmentation
GO:0048070 IEA regulation of developmental pigmentation
GO:0048087 IEA positive regulation of developmental pigmentation
GO:0048536 IEA spleen development
GO:0048538 IEA thymus development
GO:0048545 IEA response to steroid hormone
GO:0048546 IEA digestive tract morphogenesis
GO:0048589 IEA developmental growth
GO:0048599 IEA oocyte development
GO:0048743 IEA positive regulation of skeletal muscle fiber development
GO:0048753 IEA pigment granule organization
GO:0048873 IEA homeostasis of number of cells within a tissue
GO:0050790 IEA regulation of catalytic activity
GO:0050853 IMP B cell receptor signaling pathway
GO:0051384 IEA response to glucocorticoid
GO:0051402 TAS neuron apoptotic process
GO:0051434 IPI BH3 domain binding
GO:0051607 IDA defense response to virus
GO:0051721 IEA protein phosphatase 2A binding
GO:0051726 IEA regulation of cell cycle
GO:0051881 ISS regulation of mitochondrial membrane potential
GO:0051902 TAS negative regulation of mitochondrial depolarization
GO:0051924 IDA regulation of calcium ion transport
GO:0055085 IDA transmembrane transport
GO:0070059 IDA intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0071310 IEA cellular response to organic substance
GO:0071456 IEA cellular response to hypoxia
GO:0072593 IEA reactive oxygen species metabolic process
GO:0097192 IEA extrinsic apoptotic signaling pathway in absence of ligand
GO:0097193 TAS intrinsic apoptotic signaling pathway
GO:1900740 TAS positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:2000134 IEA negative regulation of G1/S transition of mitotic cell cycle
GO:2000811 IMP negative regulation of anoikis
GO:2001234 IMP negative regulation of apoptotic signaling pathway
GO:2001240 IGI negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243 IDA negative regulation of intrinsic apoptotic signaling pathway
GO:2001244 TAS positive regulation of intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000025613 bcl2 B-cell leukemia/lymphoma 2 protein_coding Danio_rerio
ENSDARG00000089109 BCL2 (2 of 2) B-cell CLL/lymphoma 2 protein_coding Danio_rerio
ENSMUSG00000057329 Bcl2 B cell leukemia/lymphoma 2 protein_coding Mus_musculus

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