C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: BCL2-antagonist/killer 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000057789 Bak1 10090 - 17:27019810-27029009 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000025034 Bak1-002 27019812-27028578 nonsense_mediated_decay
  ENSMUST00000078691 Bak1-001 27019810-27029009 protein_coding
  ENSMUST00000133448 Bak1-003 27022576-27028587 processed_transcript
  ENSMUST00000143158 Bak1-004 27020666-27022786 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaENSMUST00000025034ENSMUST00000078691
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta
ENSMUST00000025034 8.620±2.15 5.806±0.00 5.309±0.00 7.180±3.18 7.427±0.67 18.938±3.85 N/A 6.461±2.60 4.491±0.71 N/A N/A 7.714±0.53 8.558±4.75
ENSMUST00000078691 20.099±5.19 18.599±3.34 14.638±1.58 3.291±0.46 16.977±6.33 46.588±12.78 10.055±1.17 11.375±1.94 8.144±1.59 17.534±0.54 9.376±1.16 20.706±7.09 5.881±1.38

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000915 CIL_000915_0002 VISTA 17:26527896-27128643
CIL_0008HF CIL_0008HF_0002 VISTA 17:26563571-27166666
CIL_000255 CIL_000255_0002 CGP 17:27019810-27122223

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001776 IGI leukocyte homeostasis
GO:0001782 IGI B cell homeostasis
GO:0001783 IGI B cell apoptotic process
GO:0001836 IEA release of cytochrome c from mitochondria
GO:0001974 IGI blood vessel remodeling
GO:0002262 IGI myeloid cell homeostasis
GO:0002352 IGI B cell negative selection
GO:0005515 IPI protein binding
GO:0005622 IDA intracellular
GO:0005739 IDA mitochondrion
GO:0005783 IDA endoplasmic reticulum
GO:0005829 IDA cytosol
GO:0006915 IGI apoptotic process
GO:0006919 IGI activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007420 IEA brain development
GO:0007568 IEA aging
GO:0008053 IGI mitochondrial fusion
GO:0008283 IDA cell proliferation
GO:0008285 IEA negative regulation of cell proliferation
GO:0008630 IGI intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008635 IMP activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0009620 IMP response to fungus
GO:0010046 IMP response to mycotoxin
GO:0010225 IEA response to UV-C
GO:0010248 IEA establishment or maintenance of transmembrane electrochemical gradient
GO:0010332 IMP response to gamma radiation
GO:0010524 IGI positive regulation of calcium ion transport into cytosol
GO:0010629 IEA negative regulation of gene expression
GO:0014070 IEA response to organic cyclic compound
GO:0016020 IEA membrane
GO:0031018 IEA endocrine pancreas development
GO:0031072 IEA heat shock protein binding
GO:0031100 IEA organ regeneration
GO:0031966 IDA mitochondrial membrane
GO:0032471 IGI negative regulation of endoplasmic reticulum calcium ion concentration
GO:0033137 IGI negative regulation of peptidyl-serine phosphorylation
GO:0035108 IGI limb morphogenesis
GO:0042493 IEA response to drug
GO:0042542 IEA response to hydrogen peroxide
GO:0042802 IEA identical protein binding
GO:0042803 IBA protein homodimerization activity
GO:0043065 IMP positive regulation of apoptotic process
GO:0043496 IEA regulation of protein homodimerization activity
GO:0043497 IEA regulation of protein heterodimerization activity
GO:0044346 IMP fibroblast apoptotic process
GO:0045471 IEA response to ethanol
GO:0045862 IEA positive regulation of proteolysis
GO:0046902 IEA regulation of mitochondrial membrane permeability
GO:0046930 IEA pore complex
GO:0046982 IBA protein heterodimerization activity
GO:0048597 IGI post-embryonic camera-type eye morphogenesis
GO:0048872 IGI homeostasis of number of cells
GO:0051087 IEA chaperone binding
GO:0051400 IEA BH domain binding
GO:0051726 IGI regulation of cell cycle
GO:0051881 IEA regulation of mitochondrial membrane potential
GO:0060068 IGI vagina development
GO:0070059 IGI intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070242 IGI thymocyte apoptotic process
GO:0071260 IEA cellular response to mechanical stimulus
GO:0090200 IEA positive regulation of release of cytochrome c from mitochondria
GO:0097190 IEA apoptotic signaling pathway
GO:0097192 IGI extrinsic apoptotic signaling pathway in absence of ligand
GO:0097202 IEA activation of cysteine-type endopeptidase activity
GO:1900103 IEA positive regulation of endoplasmic reticulum unfolded protein response
GO:1902262 IGI apoptotic process involved in patterning of blood vessels

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000030110 BAK1 BCL2-antagonist/killer 1 protein_coding Homo_sapiens

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