C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: egl-9 family hypoxia-inducible factor 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000058709 Egln2 10090 - 7:27158658-27166802 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000080058 Egln2-001 27158658-27166802 protein_coding
  ENSMUST00000108382 Egln2-002 27158988-27166413 protein_coding
  ENSMUST00000134906 Egln2-003 27165533-27166282 processed_transcript
  ENSMUST00000152021 Egln2-004 27158659-27160871 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000080058ENSMUST00000108382
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000080058 30.480±6.27 26.747±2.28 32.656±2.09 56.409±4.73 31.763±10.87 36.302±4.14 21.165±2.49 32.350±3.34 23.542±3.37 39.147±2.26 46.370±1.41 32.790±12.77 26.538±5.73 147.306±43.21
ENSMUST00000108382 7.418±2.67 31.185±6.68 N/A N/A 13.636±3.58 13.186±1.37 N/A 8.707±2.31 11.276±1.76 11.159±0.89 N/A 18.213±7.13 4.033±0.00 151.118±39.31

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007H6 CIL_0007H6_000M CGP 7:27119909-27158668

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001666 ISS response to hypoxia
GO:0005506 IEA iron ion binding
GO:0005515 IEA protein binding
GO:0005634 ISS nucleus
GO:0005829 IEA cytosol
GO:0016706 ISS oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0018401 IEA peptidyl-proline hydroxylation to 4-hydroxy-L-proline
GO:0019826 ISS oxygen sensor activity
GO:0031418 IEA L-ascorbic acid binding
GO:0031543 IEA peptidyl-proline dioxygenase activity
GO:0031545 IEA peptidyl-proline 4-dioxygenase activity
GO:0043523 ISS regulation of neuron apoptotic process
GO:0045454 ISS cell redox homeostasis
GO:0045732 ISS positive regulation of protein catabolic process
GO:0055114 IEA oxidation-reduction process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000062562 egln2 egl nine homolog 2 (C. elegans) protein_coding Danio_rerio
ENSG00000269858 EGLN2 egl-9 family hypoxia-inducible factor 2 protein_coding Homo_sapiens

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