C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: egl-9 family hypoxia-inducible factor 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000269858 EGLN2 9606 + 19:40798996-40808433 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000303961 EGLN2-001 40799187-40808432 protein_coding
  ENST00000406058 EGLN2-002 40799515-40808432 protein_coding
  ENST00000593397 EGLN2-011 40799710-40800789 protein_coding
  ENST00000593445 EGLN2-017 40804470-40808432 retained_intron
  ENST00000593477 EGLN2-005 40806322-40808432 retained_intron
  ENST00000593525 EGLN2-018 40799725-40800803 protein_coding
  ENST00000593726 EGLN2-003 40799545-40808433 protein_coding
  ENST00000593972 EGLN2-007 40799425-40800991 protein_coding
  ENST00000594140 EGLN2-015 40803140-40808378 protein_coding
  ENST00000594380 EGLN2-010 40799707-40800835 protein_coding
  ENST00000595051 EGLN2-014 40807243-40808432 protein_coding
  ENST00000595621 EGLN2-013 40807142-40808108 protein_coding
  ENST00000596517 EGLN2-008 40799835-40800774 protein_coding
  ENST00000597746 EGLN2-012 40801290-40807936 protein_coding
  ENST00000598654 EGLN2-006 40798996-40800875 protein_coding
  ENST00000599579 EGLN2-004 40804073-40808432 retained_intron
  ENST00000601733 EGLN2-009 40799710-40800854 protein_coding
  ENST00000602166 EGLN2-016 40806919-40808068 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000303961ENST00000406058ENST00000593477ENST00000593726ENST00000594140ENST00000595621ENST00000599579ENST00000602166
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000303961 23.715±0.00 39.061±0.00 1.704±0.00 11.826±4.89 35.539±0.00 16.524±14.23 10.845±9.77 17.160±16.33 11.211±7.02 40.085±37.52 11.817±0.00 50.828±8.51 42.569±17.25 54.651±0.00
ENST00000406058 N/A N/A N/A N/A 2.663±0.00 N/A N/A N/A N/A N/A N/A N/A 15.792±0.00 89.741±27.06
ENST00000593477 N/A N/A N/A N/A N/A 1.739±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000593726 N/A N/A N/A N/A N/A 1.128±0.00 N/A N/A N/A N/A N/A N/A N/A 51.075±0.00
ENST00000594140 N/A N/A N/A N/A 3.099±0.00 N/A N/A 1.886±0.00 N/A N/A 2.198±0.00 N/A N/A N/A
ENST00000595621 N/A N/A 3.981±0.00 N/A N/A N/A 1.418±0.00 2.994±0.00 N/A N/A 1.400±0.00 N/A N/A N/A
ENST00000599579 N/A 9.354±0.00 N/A 3.433±0.00 1.183±0.00 0.763±0.00 0.374±0.00 0.531±0.00 1.160±0.00 N/A N/A 2.740±1.51 N/A N/A
ENST00000602166 N/A N/A N/A N/A N/A N/A 1.104±0.00 N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001558 NAS regulation of cell growth
GO:0001666 IDA response to hypoxia
GO:0005506 IEA iron ion binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005829 IEA cytosol
GO:0008198 NAS ferrous iron binding
GO:0016491 IEA oxidoreductase activity
GO:0016705 IEA oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706 IDA:IEA oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0018401 IDA peptidyl-proline hydroxylation to 4-hydroxy-L-proline
GO:0019826 IDA oxygen sensor activity
GO:0030520 NAS intracellular estrogen receptor signaling pathway
GO:0031418 IEA L-ascorbic acid binding
GO:0031543 IEA peptidyl-proline dioxygenase activity
GO:0031545 IDA peptidyl-proline 4-dioxygenase activity
GO:0043523 IMP regulation of neuron apoptotic process
GO:0045454 IDA cell redox homeostasis
GO:0045732 IDA positive regulation of protein catabolic process
GO:0055114 IEA oxidation-reduction process
GO:0061418 TAS regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0071456 TAS cellular response to hypoxia

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000062562 egln2 egl nine homolog 2 (C. elegans) protein_coding Danio_rerio
ENSMUSG00000058709 Egln2 egl-9 family hypoxia-inducible factor 2 protein_coding Mus_musculus

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