C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: frataxin
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000059363 Fxn 10090 - 19:24261453-24280605 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000081333 Fxn-001 24261453-24280605 protein_coding
  ENSMUST00000123684 Fxn-002 24261501-24280568 nonsense_mediated_decay
  ENSMUST00000132688 Fxn-003 24261862-24278171 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000081333ENSMUST00000123684ENSMUST00000132688
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000081333 5.838±1.40 26.797±1.94 4.131±0.52 6.249±2.06 5.519±1.43 5.706±1.64 7.160±2.94 10.119±3.21 10.626±2.52 2.649±0.09 9.493±1.58 8.146±1.98 5.204±2.63 1.807±0.77
ENSMUST00000123684 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.306±0.30 N/A
ENSMUST00000132688 N/A N/A N/A N/A 0.440±0.00 N/A N/A N/A N/A 0.458±0.07 N/A 0.817±0.19 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00086N CIL_00086N_0002 VISTA 19:24151986-24754280
CIL_0000F1 CIL_0000F1_0002 CGP 19:24261453-24555872

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004322 IEA ferroxidase activity
GO:0005515 IEA protein binding
GO:0005739 IDA mitochondrion
GO:0005829 IEA cytosol
GO:0006119 IMP oxidative phosphorylation
GO:0006783 IEA heme biosynthetic process
GO:0006811 IEA ion transport
GO:0006879 IMP cellular iron ion homeostasis
GO:0007005 IMP mitochondrion organization
GO:0007628 IMP adult walking behavior
GO:0008198 IEA ferrous iron binding
GO:0008199 IEA ferric iron binding
GO:0008284 IEA positive regulation of cell proliferation
GO:0009060 IMP aerobic respiration
GO:0009792 IMP embryo development ending in birth or egg hatching
GO:0010039 IEA response to iron ion
GO:0010722 IEA regulation of ferrochelatase activity
GO:0016226 IMP iron-sulfur cluster assembly
GO:0016540 IEA protein autoprocessing
GO:0018283 IEA iron incorporation into metallo-sulfur cluster
GO:0019230 IMP proprioception
GO:0030307 IEA positive regulation of cell growth
GO:0034986 IEA iron chaperone activity
GO:0040015 IMP negative regulation of multicellular organism growth
GO:0043066 IEA negative regulation of apoptotic process
GO:0046621 IMP negative regulation of organ growth
GO:0048554 IEA positive regulation of metalloenzyme activity
GO:0051347 IEA positive regulation of transferase activity
GO:0051349 IEA positive regulation of lyase activity
GO:0051353 IEA positive regulation of oxidoreductase activity
GO:0051536 IEA iron-sulfur cluster binding
GO:0051537 IEA 2 iron, 2 sulfur cluster binding
GO:0070301 IEA cellular response to hydrogen peroxide
GO:0090201 IEA negative regulation of release of cytochrome c from mitochondria

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000074356 fxn frataxin protein_coding Danio_rerio
ENSG00000165060 FXN frataxin protein_coding Homo_sapiens

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